ZZZ3 - zinc finger ZZ-type containing 3 Gene

Also Known as ATAC1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 26009

About ZZZ3

Cytogenetic location: 1p31.1 Genomic coordinates (GRCh38): 1:77,562,416-77,683,398 (from NCBI)

This gene has 11 transcripts (splice variants) and 216 orthologues. Ubiquitous expression in thyroid (RPKM 9.6), ovary (RPKM 6.7) and 25 other tissues.

Summary

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in histone H4 acetylation. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ZZZ3 Products (11)

mRNA Protein Name
NM_001308237.2 NP_001295166.1 ZZ-type zinc finger-containing protein 3 isoform 2
NM_001376146.1 NP_001363075.1 ZZ-type zinc finger-containing protein 3 isoform 1
NM_001376147.1 NP_001363076.1 ZZ-type zinc finger-containing protein 3 isoform 1
NM_001376148.1 NP_001363077.1 ZZ-type zinc finger-containing protein 3 isoform 3
NM_001376149.1 NP_001363078.1 ZZ-type zinc finger-containing protein 3 isoform 3
NM_001376151.1 NP_001363080.1 ZZ-type zinc finger-containing protein 3 isoform 3
NM_001376153.1 NP_001363082.1 ZZ-type zinc finger-containing protein 3 isoform 3
NM_001376154.1 NP_001363083.1 ZZ-type zinc finger-containing protein 3 isoform 3
NM_001376155.1 NP_001363084.1 ZZ-type zinc finger-containing protein 3 isoform 2
NM_001376156.1 NP_001363085.1 ZZ-type zinc finger-containing protein 3 isoform 4
NM_015534.6 NP_056349.1 ZZ-type zinc finger-containing protein 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables histone reader activity IDA
IDA: Inferred from direct assay
30217978 GOA
enables lysine-acetylated histone binding IDA
IDA: Inferred from direct assay
30217978 GOA
enables methylated histone binding IDA
IDA: Inferred from direct assay
30217978 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20562830 GOA
Biological Process GO Annotation Evidence References Source
involved in chromatin organization IMP
IMP: Inferred from mutant phenotype
30217978 GOA
involved in regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
19936620 GOA
involved in regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
19103755 GOA
involved in regulation of cell division IDA
IDA: Inferred from direct assay
20562830 GOA
involved in regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
22055187 GOA
involved in regulation of tubulin deacetylation IMP
IMP: Inferred from mutant phenotype
20562830 GOA
Cellular Component GO Annotation Evidence References Source
part of ATAC complex IDA
IDA: Inferred from direct assay
19936620 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZZZ3 Protein Structure

Myb_DNA-binding

Myb_DNA-binding: Myb-like DNA-binding domain (654 - 702)

ZZ

ZZ: Zinc finger, ZZ type (818 - 855)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 903 a.a.
Protein Preferred Names Protein Names

ZZ-type zinc finger-containing protein 3

  • ATAC component 1 homolog

ZZZ3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZZZ3 Q8IYH5 PPP1R13B Homo sapiens Q96KQ4
Y2H Prey Pooling
32296183
Intra
ZZZ3 Q8IYH5 PPP1R13B Homo sapiens Q96KQ4
Validated Y2H
32296183
Intra
ZZZ3 Q8IYH5 PPP1R13B Homo sapiens Q96KQ4
Y2H Array
32296183
Intra
ZZZ3 Q8IYH5 CARD9 Homo sapiens Q9H257-2
Validated Y2H
32296183
Intra
ZZZ3 Q8IYH5 CARD9 Homo sapiens Q9H257-2
Y2H Array
32296183
Intra
ZZZ3 Q8IYH5 CARD9 Homo sapiens Q9H257-2
Y2H Prey Pooling
32296183
Intra
ZZZ3 Q8IYH5 EFHC2 Homo sapiens Q5JST6
Y2H Prey Pooling
32296183
Intra
ZZZ3 Q8IYH5 EFHC2 Homo sapiens Q5JST6
Y2H Array
32296183
Intra
ZZZ3 Q8IYH5 TRAF2 Homo sapiens Q12933
Y2H Array
32296183
Intra
ZZZ3 Q8IYH5 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
32296183
Cross
ZZZ3 Q8IYH5 Hoxa1 Mus musculus P09022
Pull Down
23088713
Intra
ZZZ3 Q8IYH5 KAT2A Homo sapiens Q92830
Anti Bait CoIP
20562830
Intra
ZZZ3 Q8IYH5 WDR5 Homo sapiens P61964
Anti Bait CoIP
24981860
Intra
ZZZ3 Q8IYH5 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
ZZZ3 Q8IYH5 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
ZZZ3 Q8IYH5 FAM124A Homo sapiens Q86V42
Y2H Array
25416956
Intra
ZZZ3 Q8IYH5 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra
ZZZ3 Q8IYH5 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra
ZZZ3 Q8IYH5 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Combined Oxidative Phosphorylation Deficiency 24

  • COXPD24

  • Combined Oxidative Phosphorylation Defect Type 24

  • Oxidative Phosphorylation Deficiency, Combined, Type 24
Combined Oxidative Phosphorylation Deficiency 20

  • COXPD20

  • Combined Oxidative Phosphorylation Defect Type 20

  • Oxidative Phosphorylation Deficiency, Combined, Type 20
Buruli Ulcer

  • Buruli Ulcer, Susceptibility To

  • Buruli Ulcer Disease

  • Mycobacterium Ulcerans

  • Mycobacterium Ulcerans, Susceptibility To

  • Bairnsdale Ulcer

  • Daintree Ulcer

  • Mossman Ulcer

  • Searl Ulcer

  • Searle'S Ulcer

  • Bud
Histiocytoid Hemangioma

  • Angiolymphoid Hyperplasia With Eosinophilia

  • Epithelioid Haemangioma

  • Epithelioid Hemangioma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16217 ZZZ3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ZZZ3 VGNC VGNC:67396
Mus musculus ZZZ3 MGD MGI:1920453
Bos taurus ZZZ3 VGNC VGNC:37397
Rattus norvegicus ZZZ3 RGD RGD:1565468
Macaca mulatta ZZZ3 VGNC VGNC:106535
Canis familiaris ZZZ3 VGNC VGNC:48871
Others ZZZ3 NCBI