2. Gene
  3. WDR5 - WD repeat domain 5 Gene

WDR5 - WD repeat domain 5 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as BIG3; SWD3; BIG-3; CFAP89

Gene ID: 11091 | Gene type: protein coding

About WDR5

Cytogenetic location: 9q34.2 Genomic coordinates (GRCh38): 9:134,135,199-134,159,968 (from NCBI)

This gene has 3 transcripts (splice variants), 171 orthologues and 26 paralogues. Ubiquitous expression in testis (RPKM 24.2), skin (RPKM 8.5) and 25 other tissues.

Summary

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 Amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, Apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

WDR5 Products(13)

mRNA Protein Name
NM_001384409.1 NP_001371338.1 WD repeat-containing protein 5 isoform 1
NM_001384410.1 NP_001371339.1 WD repeat-containing protein 5 isoform 1
NM_001384411.1 NP_001371340.1 WD repeat-containing protein 5 isoform 1
NM_001384412.1 NP_001371341.1 WD repeat-containing protein 5 isoform 1
NM_001384413.1 NP_001371342.1 WD repeat-containing protein 5 isoform 1
NM_001384414.1 NP_001371343.1 WD repeat-containing protein 5 isoform 1
NM_001384415.1 NP_001371344.1 WD repeat-containing protein 5 isoform 1
NM_001384416.1 NP_001371345.1 WD repeat-containing protein 5 isoform 2
NM_001384417.1 NP_001371346.1 WD repeat-containing protein 5 isoform 3
NM_001384418.1 NP_001371347.1 WD repeat-containing protein 5 isoform 4
NM_001384419.1 NP_001371348.1 WD repeat-containing protein 5 isoform 4
NM_017588.3 NP_060058.1 WD repeat-containing protein 5 isoform 1
NM_052821.4 NP_438172.1 WD repeat-containing protein 5 isoform 1

WDR5 Protein Structure

WD40

WD40: WD domain, G-beta repeat (38 - 72)

WD40

WD40: WD domain, G-beta repeat (78 - 115)

WD40

WD40: WD domain, G-beta repeat (119 - 157)

WD40

WD40: WD domain, G-beta repeat (161 - 199)

WD40

WD40: WD domain, G-beta repeat (204 - 242)

WD40

WD40: WD domain, G-beta repeat (246 - 287)

WD40

WD40: WD domain, G-beta repeat (292 - 331)

  • 0
  • 100
  • 200
  • 300
  • 334 a.a.
Protein Preferred Names Protein Names

WD repeat-containing protein 5

BMP2-induced 3-kb gene protein

Related Diseases

Diseases Alias
Ciliary Dyskinesia, Primary, 33

Primary Ciliary Dyskinesia 33

CILD33

Ciliary Dyskinesia, Primary, 33, Without Situs Inversus

Primary Ciliary Dyskinesia 33 Without Situs Inversus
Kabuki Syndrome 1

Kabuki Syndrome

Niikawa-Kuroki Syndrome

Kabuki Make-Up Syndrome

Kms

KABUK1

Kabuki Make Up Syndrome

Nks

Kabuki Makeup Syndrome

Kabuki Syndrome, Type 1
Kleefstra Syndrome

9q34.3 Microdeletion Syndrome

9q Subtelomeric Deletion Syndrome

9q- Syndrome

Chromosome 9q Deletion Syndrome

9q34.3 Deletion Syndrome

9qstds

Chromosome 9q34.3 Deletion Syndrome

Chromosome 9, Trisomy 9q
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-16994 OICR-0547 Inhibitor 99.93% Phase 1
Pre-clinical Phase
Bioactive Molecules (32)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16993 OICR-9429 99.71% Unkown
HY-141796 MS67 Inhibitor 98.73% Unkown
HY-19347 WDR5-0103 Antagonist 99.93% Unkown
HY-12220A MM-102 TFA Inhibitor 99.77% Unkown
HY-133121 WDR5-IN-1 98.71% Unkown
HY-111753A WDR5-IN-4 TFA Inhibitor 99.87% Unkown
HY-150654 WDR5-IN-5 Inhibitor 98.92% Unkown
HY-12220 MM-102 Inhibitor 99.17% Unkown
HY-154949 WDR5-IN-6 Inhibitor 99.89% Unkown
HY-19554A MM-401 TFA 99.62% Unkown
HY-100869A MM-589 TFA Inhibitor 98.67% Unkown
HY-132233A DDO-2093 dihydrochloride Inhibitor 98.52% Unkown
HY-100869B MM-589 (racemic mixture ) (TFA) Inhibitor 99.83% Unkown
HY-141799 Dimethyl-F-OICR-9429-COOH 98.05% Unkown
HY-100869 MM-589 Inhibitor / Unkown
HY-132233 DDO-2093 Inhibitor / Unkown
HY-111753 WDR5-IN-4 Inhibitor / Unkown
HY-148817 WDR5-0102 Inhibitor 97.02% Unkown
HY-153728 WM-586 Inhibitor / Unkown
HY-141797 MS33 Inhibitor / Unkown
HY-141798 OICR-9429-N-C2-NH2 / Unkown
HY-149873 Anticancer agent 126 Inhibitor / Unkown
HY-150400 XF056-132 free base Inhibitor / Unkown
HY-150403 XF067-68 Inhibitor / Unkown
HY-153331 DDO-2213 Inhibitor / Unkown
HY-154847 WM-662 Inhibitor / Unkown
HY-157332 WDR5-IN-7 Inhibitor / Unkown
HY-161123 WDR5-IN-8 Inhibitor / Unkown
HY-162014 WDR5 degrader-1 / Unkown
HY-19554 MM-401 / Unkown
HY-RS15785 WDR5 Human Pre-designed siRNA Set A / Unkown
HY-RS15789 WDR5B Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta WDR5 VGNC VGNC:103886
Felis catus WDR5 VGNC VGNC:67039
Bos taurus WDR5 VGNC VGNC:58619
Canis familiaris WDR5 VGNC VGNC:48373
Mus musculus WDR5 MGD MGI:2155884
Rattus norvegicus WDR5 RGD RGD:1305159