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Cat. No.: HY-163774

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WDR5-MYC-IN-1

WDR5-MYC-IN-1 (compound 4o) is a potent WDR5-MYC interaction inhibitor with a Ki value of 1.0 µM. WDR5-MYC-IN-1 shows antiproliferative activity.

For research use only. We do not sell to patients.

Formula: C₁₂H₁₀N₄OS₂
Molecular Weight:290.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

WDR5-MYC-IN-1 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

WDR5-MYC-IN-1 (compound 4o) is a potent WDR5-MYC interaction inhibitor with a Ki value of 1.0 µM. WDR5-MYC-IN-1 shows antiproliferative activity^[1].

IC₅₀ & Target

K_i: 1.0 µM (WDR5-MYC)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	IC₅₀	5.32 μM Compound: 4o	Antiproliferative activity against human HL-60 cells incubated for 72 hrs by SRB assay Antiproliferative activity against human HL-60 cells incubated for 72 hrs by SRB assay	[PMID: 39015274]
NCI-H1299	IC₅₀	7.4 μM Compound: 4o	Antiproliferative activity against human NCI-H1299 cells incubated for 72 hrs by SRB assay Antiproliferative activity against human NCI-H1299 cells incubated for 72 hrs by SRB assay	[PMID: 39015274]
Raji	IC₅₀	1.52 μM Compound: 4o	Antiproliferative activity against human Raji cells incubated for 72 hrs by SRB assay Antiproliferative activity against human Raji cells incubated for 72 hrs by SRB assay	[PMID: 39015274]
Ramos	IC₅₀	1.51 μM Compound: 4o	Antiproliferative activity against human Ramos cells incubated for 72 hrs by SRB assay Antiproliferative activity against human Ramos cells incubated for 72 hrs by SRB assay	[PMID: 39015274]
SUD4	IC₅₀	2.2 μM Compound: 4o	Antiproliferative activity against human SU-DHL-4 cells incubated for 72 hrs by SRB assay Antiproliferative activity against human SU-DHL-4 cells incubated for 72 hrs by SRB assay	[PMID: 39015274]

In Vitro

WDR5-MYC-IN-1 (compound 4o) shows antiproliferative activity with IC₅₀s of 1.52, 1.51, 2.20, 5.32, 7.40 µM for RAJI, RAMOS, SUDHL4, HL-60, H1299 cells, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

RAJI, RAMOS, SUDHL4, HL-60, H1299 cells
Concentration:
Incubation Time:
Result:

Showed antiproliferative activity with IC₅₀s of 1.52, 1.51, 2.20, 5.32, 7.40 µM for RAJI, RAMOS, SUDHL4, HL-60, H1299 cells, respectively.

Chemical Information

Molecular Weight 290.36
Formula C₁₂H₁₀N₄OS₂
SMILES

O=C(NC)C1=CC=C(C2=C(SC#N)SC(N)=N2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang H, et al. Identification of 5-Thiocyanatothiazol-2-amines Disrupting WDR5-MYC Protein-Protein Interactions. ACS Med Chem Lett. 2024 Jul 1;15(7):1143-1150. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

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100 mg

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