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製品番号: HY-163774

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WDR5-MYC-IN-1

WDR5-MYC-IN-1 (compound 4o) is a potent WDR5-MYC interaction inhibitor with a Ki value of 1.0 µM. WDR5-MYC-IN-1 shows antiproliferative activity.

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分子式: C₁₂H₁₀N₄OS₂
分子量:290.36

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

WDR5-MYC-IN-1 構造式

容量

価格（税別）

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数量

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

WDR5-MYC-IN-1 (compound 4o) is a potent WDR5-MYC interaction inhibitor with a Ki value of 1.0 µM. WDR5-MYC-IN-1 shows antiproliferative activity^[1].

IC₅₀ & Target

K_i: 1.0 µM (WDR5-MYC)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	IC₅₀	5.32 μM Compound: 4o	Antiproliferative activity against human HL-60 cells incubated for 72 hrs by SRB assay Antiproliferative activity against human HL-60 cells incubated for 72 hrs by SRB assay	[PMID: 39015274]
NCI-H1299	IC₅₀	7.4 μM Compound: 4o	Antiproliferative activity against human NCI-H1299 cells incubated for 72 hrs by SRB assay Antiproliferative activity against human NCI-H1299 cells incubated for 72 hrs by SRB assay	[PMID: 39015274]
Raji	IC₅₀	1.52 μM Compound: 4o	Antiproliferative activity against human Raji cells incubated for 72 hrs by SRB assay Antiproliferative activity against human Raji cells incubated for 72 hrs by SRB assay	[PMID: 39015274]
Ramos	IC₅₀	1.51 μM Compound: 4o	Antiproliferative activity against human Ramos cells incubated for 72 hrs by SRB assay Antiproliferative activity against human Ramos cells incubated for 72 hrs by SRB assay	[PMID: 39015274]
SUD4	IC₅₀	2.2 μM Compound: 4o	Antiproliferative activity against human SU-DHL-4 cells incubated for 72 hrs by SRB assay Antiproliferative activity against human SU-DHL-4 cells incubated for 72 hrs by SRB assay	[PMID: 39015274]

体外実験

WDR5-MYC-IN-1 (compound 4o) shows antiproliferative activity with IC₅₀s of 1.52, 1.51, 2.20, 5.32, 7.40 µM for RAJI, RAMOS, SUDHL4, HL-60, H1299 cells, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

RAJI, RAMOS, SUDHL4, HL-60, H1299 cells
Concentration:
Incubation Time:
Result:

Showed antiproliferative activity with IC₅₀s of 1.52, 1.51, 2.20, 5.32, 7.40 µM for RAJI, RAMOS, SUDHL4, HL-60, H1299 cells, respectively.

化学情報

分子量 290.36
分子式 C₁₂H₁₀N₄OS₂
SMILES

O=C(NC)C1=CC=C(C2=C(SC#N)SC(N)=N2)C=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (269 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Wang H, et al. Identification of 5-Thiocyanatothiazol-2-amines Disrupting WDR5-MYC Protein-Protein Interactions. ACS Med Chem Lett. 2024 Jul 1;15(7):1143-1150. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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