1. Epigenetics
  2. Histone Methyltransferase
  3. WDR5-IN-4

WDR5-IN-4 

Cat. No.: HY-111753
Handling Instructions

WDR5-IN-4 is an inhibitor of the WIN site of chromatin-associated WD repeat-containing protein 5 (WDR5), with a Kd of 0.1 nM. WDR5-IN-4 displaces WDR5 from chromatin and decreases the expression of associated genes, causing translational inhibition, nucleolar stress. Anti-cancer activity.

For research use only. We do not sell to patients.

WDR5-IN-4 Chemical Structure

WDR5-IN-4 Chemical Structure

CAS No. : 2407457-36-5

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Description

WDR5-IN-4 is an inhibitor of the WIN site of chromatin-associated WD repeat-containing protein 5 (WDR5), with a Kd of 0.1 nM. WDR5-IN-4 displaces WDR5 from chromatin and decreases the expression of associated genes, causing translational inhibition, nucleolar stress. Anti-cancer activity[1].

IC50 & Target

Kd: 0.1 nM (WIN)[1]

Molecular Weight

498.38

Formula

C₂₅H₂₂Cl₂FN₅O

CAS No.

2407457-36-5

SMILES

ClC1=CC=C(CNC(C2=CC(CN3C(N(C)C=C3)=N)=CC(C4=C(C)N=C(F)C=C4)=C2)=O)C=C1Cl

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

WDR5-IN-4Histone MethyltransferaseInhibitorinhibitorinhibit

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