2. Epigenetics
  3. Histone Methyltransferase
  4. WDR5-IN-4 TFA

WDR5-IN-4 TFA is an inhibitor of the WIN site of chromatin-associated WD repeat-containing protein 5 (WDR5), with a Kd of 0.1 nM. WDR5-IN-4 TFA displaces WDR5 from chromatin and decreases the expression of associated genes, causing translational inhibition, nucleolar stress. Anti-cancer activity.

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WDR5-IN-4 TFA Chemical Structure

WDR5-IN-4 TFA Chemical Structure

CAS No. : 2749300-35-2

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 472 In-stock
Solution
10 mM * 1 mL in DMSO USD 472 In-stock
Solid
5 mg USD 350 In-stock
10 mg USD 550 In-stock
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Based on 3 publication(s) in Google Scholar

Other Forms of WDR5-IN-4 TFA:

WDR5-IN-4 TFA Related Antibodies

Top Publications Citing Use of Products

View All Histone Methyltransferase Isoform Specific Products:

View All Isoforms
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

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Description

WDR5-IN-4 TFA is an inhibitor of the WIN site of chromatin-associated WD repeat-containing protein 5 (WDR5), with a Kd of 0.1 nM. WDR5-IN-4 TFA displaces WDR5 from chromatin and decreases the expression of associated genes, causing translational inhibition, nucleolar stress. Anti-cancer activity[1].

Molecular Weight

612.40

Formula

C27H23Cl2F4N5O3
CAS No.
Appearance

Solid

Color

Light yellow to orange

SMILES

ClC1=CC=C(CNC(C2=CC(CN3C(N(C)C=C3)=N)=CC(C4=C(C)N=C(F)C=C4)=C2)=O)C=C1Cl.O=C(O)C(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 250 mg/mL (408.23 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6329 mL 8.1646 mL 16.3292 mL
5 mM 0.3266 mL 1.6329 mL 3.2658 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6329 mL 8.1646 mL 16.3292 mL 40.8230 mL
5 mM 0.3266 mL 1.6329 mL 3.2658 mL 8.1646 mL
10 mM 0.1633 mL 0.8165 mL 1.6329 mL 4.0823 mL
15 mM 0.1089 mL 0.5443 mL 1.0886 mL 2.7215 mL
20 mM 0.0816 mL 0.4082 mL 0.8165 mL 2.0411 mL
25 mM 0.0653 mL 0.3266 mL 0.6532 mL 1.6329 mL
30 mM 0.0544 mL 0.2722 mL 0.5443 mL 1.3608 mL
40 mM 0.0408 mL 0.2041 mL 0.4082 mL 1.0206 mL
50 mM 0.0327 mL 0.1633 mL 0.3266 mL 0.8165 mL
60 mM 0.0272 mL 0.1361 mL 0.2722 mL 0.6804 mL
80 mM 0.0204 mL 0.1021 mL 0.2041 mL 0.5103 mL
100 mM 0.0163 mL 0.0816 mL 0.1633 mL 0.4082 mL
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WDR5-IN-4 TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WDR5-IN-42749300-35-2Histone MethyltransferaseInhibitorinhibitorinhibit

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