MEN1 - menin 1 Gene
Also Known as MEAI; SCG2
Species: Homo sapiens
About MEN1
This gene has 18 transcripts (splice variants), 177 orthologues and is associated with 105 phenotypes. Ubiquitous expression in spleen (RPKM 7.6), lymph node (RPKM 7.0) and 25 other tissues.
Summary
This gene encodes menin, a tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. Menin is a scaffold protein that functions in histone modification and epigenetic gene regulation. It is thought to regulate several pathways and processes by altering chromatin structure through the modification of histones. [provided by RefSeq, May 2019]
MEN1 Products (24)
| mRNA | Protein | Name |
|---|---|---|
| NM_000244.4 | NP_000235.3 | menin isoform 1 |
| NM_001370251.2 | NP_001357180.2 | menin isoform 3 |
| NM_001370259.2 | NP_001357188.2 | menin isoform 2 |
| NM_001370260.2 | NP_001357189.2 | menin isoform 2 |
| NM_001370261.2 | NP_001357190.2 | menin isoform 2 |
| NM_001370262.2 | NP_001357191.2 | menin isoform 4 |
| NM_001370263.2 | NP_001357192.2 | menin isoform 4 |
| NM_001407142.1 | NP_001394071.1 | menin isoform 3 |
| NM_001407143.1 | NP_001394072.1 | menin isoform 3 |
| NM_001407144.1 | NP_001394073.1 | menin isoform 3 |
| NM_001407145.1 | NP_001394074.1 | menin isoform 1 |
| NM_001407146.1 | NP_001394075.1 | menin isoform 2 |
| NM_001407147.1 | NP_001394076.1 | menin isoform 2 |
| NM_001407148.1 | NP_001394077.1 | menin isoform 4 |
| NM_001407149.1 | NP_001394078.1 | menin isoform 4 |
| NM_001407150.1 | NP_001394079.1 | menin isoform 5 |
| NM_001407151.1 | NP_001394080.1 | menin isoform 6 |
| NM_001407152.1 | NP_001394081.1 | menin isoform 7 |
| NM_130799.3 | NP_570711.2 | menin isoform 2 |
| NM_130800.3 | NP_570712.2 | menin isoform 1 |
| NM_130801.3 | NP_570713.2 | menin isoform 1 |
| NM_130802.3 | NP_570714.2 | menin isoform 1 |
| NM_130803.3 | NP_570715.2 | menin isoform 1 |
| NM_130804.3 | NP_570716.2 | menin isoform 1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables R-SMAD binding |
IPI
IPI: Inferred from physical interaction
|
11274402 | GOA |
| enables Y-form DNA binding |
IDA
IDA: Inferred from direct assay
|
15331604 | GOA |
| enables double-stranded DNA binding |
IDA
IDA: Inferred from direct assay
|
15331604 | GOA |
| enables four-way junction DNA binding |
IDA
IDA: Inferred from direct assay
|
15331604 | GOA |
| enables phosphoprotein binding |
IPI
IPI: Inferred from physical interaction
|
14992727 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
9989505 | GOA |
| enables protein-macromolecule adaptor activity |
IDA
IDA: Inferred from direct assay
|
20484083 | GOA |
| enables transcription cis-regulatory region binding |
IDA
IDA: Inferred from direct assay
|
20484083 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| part of MLL1 complex |
IPI
IPI: Inferred from physical interaction
|
23508102 | GOA |
| part of MLL1/2 complex |
IPI
IPI: Inferred from physical interaction
|
23508102 | GOA |
| located in chromatin |
IDA
IDA: Inferred from direct assay
|
12837246 | GOA |
| located in cleavage furrow |
IDA
IDA: Inferred from direct assay
|
14508515 | GOA |
| located in cytoplasm |
IDA
IDA: Inferred from direct assay
|
11500056 | GOA |
| located in cytosol |
IDA
IDA: Inferred from direct assay
|
14508515 | GOA |
| part of histone methyltransferase complex |
IDA
IDA: Inferred from direct assay
|
17500065 | GOA |
| located in nuclear matrix |
IDA
IDA: Inferred from direct assay
|
12874027 | GOA |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
9465067 | GOA |
| part of protein-containing complex |
IDA
IDA: Inferred from direct assay
|
15199122 | GOA |
| part of transcription repressor complex |
IPI
IPI: Inferred from physical interaction
|
22327296 | GOA |
MEN1 Protein Structure
Menin: Menin (1 - 609)
- 0
- 100
- 200
- 300
- 400
- 500
- 610 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
menin |
|
MEN1 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
MEN1 | O00255 | MYH9 | Homo sapiens | P35579 | 14508515 | |
|
Intra
|
MEN1 | O00255 | MYH9 | Homo sapiens | P35579 | 14508515 | |
|
Intra
|
MEN1 | O00255 | MYH9 | Homo sapiens | P35579 | 14508515 | |
|
Intra
|
MEN1 | O00255 | FANCD2 | Homo sapiens | Q9BXW9 | 12874027 | |
|
Intra
|
MEN1 | O00255 | FANCD2 | Homo sapiens | Q9BXW9 | 12874027 | |
|
Intra
|
MEN1 | O00255 | WDR5 | Homo sapiens | P61964 | 24981860 | |
|
Intra
|
MEN1 | O00255 | P19838-PRO_0000030311 | Homo sapiens | P19838-PRO_0000030311 | 11526476 |
MEN1 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P81928 | Menin Antibody (YA1673) | WB, IHC-P, ICC/IF, IP | Human, Mouse, Rat |
| HY-P81928A | Menin Antibody (YA1673)(PBS only) | WB, IP | Human, Rat |
| HY-P83789 | MEN1 Antibody (YA3486) | IHC-P, FC, ELISA | Human |
| HY-P83789A | MEN1 Antibody (YA3486)(PBS only) | IHC-P, FC, ELISA | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Multiple Endocrine Neoplasia, Type I |
|
|
| Pituitary Adenoma 1, Multiple Types |
|
|
| Hyperparathyroidism 1 |
|
|
| Insulinoma |
|
|
| Primary Hyperparathyroidism |
|
|
| Parathyroid Adenoma |
|
|
| Adrenal Adenoma |
|
|
| Adrenal Cortical Adenoma |
|
|
| Cellular Ependymoma |
|
|
| Tanycytic Ependymoma |
|
|
| Papillary Ependymoma |
|
|
| Clear Cell Ependymoma |
|
|
| Growth Hormone Secreting Pituitary Adenoma |
|
|
| Conn'S Syndrome |
|
|
| Thyroid Carcinoma, Familial Medullary |
|
|
| Gastrointestinal Stromal Tumor |
|
|
| Diabetes Mellitus |
|
|
| Hypertension, Essential |
|
|
| Bap1 Tumor Predisposition Syndrome |
|
|
| Inherited Cancer-Predisposing Syndrome |
|
|
| Prolactinoma |
|
|
| Multiple Endocrine Neoplasia |
|
|
| Gastrinoma |
|
|
| Silent Pituitary Adenoma |
|
|
| Null Pituitary Adenoma |
|
|
| Hyperparathyroidism |
|
|
| Zollinger-Ellison Syndrome |
|
|
| Multiple Endocrine Neoplasia, Type Iia |
|
|
| Parathyroid Carcinoma |
|
|
| Parathyroid Gland Disease |
|
|
| Lipomatosis |
|
|
| Duodenal Gastrinoma |
|
|
| Hyperparathyroidism 2 With Jaw Tumors |
|
|
| Lipomatosis, Multiple |
|
|
| Pancreatic Cystadenoma |
|
|
| Skin Lipoma |
|
|
| Pituitary Tumors |
|
|
| Vipoma |
|
|
| Peptic Ulcer Disease |
|
|
| Parathyroid Transitional Clear Cell Adenoma |
|
|
| Islet Cell Tumor |
|
|
| Pancreatic Gastrinoma |
|
|
| Ureter Leiomyoma |
|
|
| Secondary Hyperparathyroidism |
|
|
| Acromegaly |
|
|
| Pituitary Gland Disease |
|
|
| Neuroendocrine Tumor |
|
|
| Adenoma |
|
|
| Paraganglioma |
|
|
| Pituitary Adenoma |
|
|
| Pituitary Cancer |
|
|
| Pheochromocytoma |
|
|
| Duodenum Cancer |
|
|
| Hormone Producing Pituitary Cancer |
|
|
| Multiple Endocrine Neoplasia, Type Iib |
|
|
| Multiple Endocrine Neoplasia, Type Iv |
|
|
| Non-Functioning Pancreatic Endocrine Tumor |
|
|
| Duodenum Disease |
|
|
| Von Hippel-Lindau Syndrome |
|
|
| Functioning Pituitary Adenoma |
|
|
| Carcinoid Tumors, Intestinal |
|
|
| Gastrointestinal Neuroendocrine Tumor |
|
|
| Adrenal Carcinoma |
|
|
| Neuroendocrine Carcinoma |
|
|
| Carney Complex Variant |
|
|
| Atrophic Gastritis |
|
|
| Multiple Mucosal Neuroma |
|
|
| Familial Hypocalciuric Hypercalcemia |
|
|
| Small Intestine Cancer |
|
|
| Pancreatic Endocrine Carcinoma |
|
|
| Gastrointestinal Neuroendocrine Benign Tumor |
|
|
| Hemangioma |
|
|
| Endocrine Organ Benign Neoplasm |
|
|
| Duodenal Somatostatinoma |
|
|
| Prolactin Producing Pituitary Tumor |
|
|
| Ossifying Fibroma |
|
|
| Small Intestine Neuroendocrine Neoplasm |
|
|
| Meningioma, Familial |
|
|
| Pancreatic Cholera |
|
|
| Lissencephaly, X-Linked, 2 |
|
|
| Gastric Neuroendocrine Neoplasm |
|
|
| Somatostatinoma |
|
|
| Pancreatic Cancer |
|
|
| Endocrine Pancreas Disease |
|
|
| Gastrointestinal System Benign Neoplasm |
|
|
| Thyroid Gland Cancer |
|
|
| Pancreatic Somatostatinoma |
|
|
| Hyperpituitarism |
|
|
| Pituitary Infarct |
|
|
| Gastritis, Familial Giant Hypertrophic |
|
|
| Neurofibromatosis, Type I |
|
|
| Cecal Benign Neoplasm |
|
|
| Cecum Adenoma |
|
|
| Mahvash Disease |
|
|
| Hypocalciuric Hypercalcemia, Familial, Type I |
|
|
| Mccune-Albright Syndrome |
|
|
| Pulmonary Neuroendocrine Tumor |
|
|
| Acth-Independent Macronodular Adrenal Hyperplasia |
|
|
| Adrenal Gland Disease |
|
|
| Thyroid Gland Medullary Carcinoma |
|
|
| Hyperinsulinemic Hypoglycemia |
|
|
| Gastric Gastrinoma |
|
|
| Small Intestine Benign Neoplasm |
|
|
| Large Cell Neuroendocrine Carcinoma |
|
|
| Pancreatic Serous Cystadenoma |
|
|
| Dicer1 Syndrome |
|
|
| Hypocalciuric Hypercalcemia, Familial, Type Ii |
|
|
| Sublingual Gland Cancer |
|
|
| Acth-Secreting Pituitary Adenoma |
|
|
| Primary Pigmented Nodular Adrenocortical Disease |
|
|
| Mineral Metabolism Disease |
|
|
| Cell Type Benign Neoplasm |
|
|
| Adrenal Cortex Disease |
|
|
| Esophageal Neuroendocrine Tumor |
|
|
| Lung Large Cell Carcinoma |
|
|
| Cardiovascular Organ Benign Neoplasm |
|
|
| Paraganglioma And Gastric Stromal Sarcoma |
|
|
| Serotonin Syndrome |
|
|
| Li-Fraumeni Syndrome |
|
|
| Adrenal Cortical Carcinoma |
|
|
| Cowden Syndrome |
|
|
| Fanconi Anemia, Complementation Group A |
|
|
| Lynch Syndrome |
|
|
| Beckwith-Wiedemann Syndrome |
|
|
| Alpha-Thalassemia |
|
|
| Hereditary Breast Ovarian Cancer Syndrome |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Canis familiaris | MEN1 | VGNC | VGNC:43156 |
| Macaca mulatta | MEN1 | VGNC | VGNC:107458 |
| Felis catus | MEN1 | VGNC | VGNC:68233 |
| Mus musculus | MEN1 | MGD | MGI:1316736 |
| Rattus norvegicus | MEN1 | RGD | RGD:3078 |
| Bos taurus | MEN1 | VGNC | VGNC:31385 |
| Others | MEN1 | NCBI |