BOD1L1 - biorientation of chromosomes in cell division 1 like 1 Gene

Also Known as BOD1L; FAM44A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 259282

About BOD1L1

Cytogenetic location: 4p15.33 Genomic coordinates (GRCh38): 4:13,568,738-13,627,725 (from NCBI)

This gene has 6 transcripts (splice variants), 208 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 8.2), testis (RPKM 7.4) and 25 other tissues.

Summary

Predicted to enable protein Phosphatase 2A binding activity and protein Phosphatase Inhibitor activity. Involved in cellular response to DNA damage stimulus and replication fork processing. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

BOD1L1 Products (1)

mRNA	Protein	Name
NM_148894.3	NP_683692.2	biorientation of chromosomes in cell division protein 1-like 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24981860	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	26166705	GOA
involved in replication fork processing	IDA IDA: Inferred from direct assay	26166705	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Set1C/COMPASS complex	IPI IPI: Inferred from physical interaction	23508102	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BOD1L1 Protein Structure

COMPASS-Shg1

0
500
1000
1500
2000
2500
3051 a.a.

Protein Preferred Names	Protein Names
biorientation of chromosomes in cell division protein 1-like 1	biorientation of chromosomes in cell division 1-like

BOD1L1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	BOD1L1	Q8NFC6	WDR5	Homo sapiens	P61964	Anti Bait CoIP	24981860

Cross: Cross-species interaction Intra: Intraspecies interaction

BOD1L1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810271	FAM44A Antibody (YA9615)	WB, ICC/IF, IF-Tissue, IP, ELISA	human

Related Diseases

Diseases	Alias
Schimke Immunoosseous Dysplasia	Schimke Immuno-Osseous Dysplasia SIOD Immunoosseous Dysplasia, Schimke Type Schimke Syndrome Immunoosseous Dysplasia Schimke Type Spondyloepiphyseal Dysplasia - Nephrotic Syndrome Spondyloepiphyseal Dysplasia Nephrotic Syndrome Spondyloepiphyseal Dysplasia-Nephrotic Syndrome
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122236	UMK57		99.51%	Unkown
HY-RS01569	BOD1L1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	BOD1L1	VGNC	VGNC:38496
Felis catus	BOD1L1	VGNC	VGNC:78458
Bos taurus	BOD1L1	VGNC	VGNC:26537
Rattus norvegicus	BOD1L1	RGD	RGD:621413
Macaca mulatta	BOD1L1	VGNC	VGNC:97741
Mus musculus	BOD1L1	MGD	MGI:2444804
Others	BOD1L1	NCBI