PROTAC WDR5 degrader 2 

PROTAC WDR5 degrader 2 is a WDR5 PROTAC degrader. PROTAC WDR5 degrader 2 induces WDR5 degradation via the ubiquitin-proteasome system by forming a ternary complex with WDR5 and an E3 ligase. PROTAC WDR5 degrader 2 can be used in leukemia-related research^[1]. (Pink: WDR5 ligand (HY-181973); Blue: VHL ligand (HY-125845); Black: linker (HY-N0216)).

PROTAC WDR5 degrader 2 (Compound A11 + X37) (1 μM; 6 h-12 h) significantly degrades WDR5 in MV4-11^WDR5‑HiBiT and MV4-11^{WDR5‑Nluc (Kless)} cells when treated at 1 μM for 6 h or 12 h, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1228.36

C₆₃H₆₉F₄N₁₃O₇S

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Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Mitrović M, et al. Click. Screen. Degrade. A Miniaturized D2B Workflow for Rapid PROTAC Discovery. J Med Chem. 2026;69(3):2599-2624.  [Content Brief]