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Cat. No.: HY-181973

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WDR5 ligand 3

WDR5 ligand 3 is a WDR5 ligand that can be used for the synthesis of PORTACs, such as PROTAC WDR5 degrader 2 (HY-181972).

For research use only. We do not sell to patients.

Formula: C₃₄H₃₆F₄N₆O₃
Molecular Weight:652.68

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

WDR5 ligand 3 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

WDR5 ligand 3 is a WDR5 ligand that can be used for the synthesis of PORTACs, such as PROTAC WDR5 degrader 2 (HY-181972)^[1].

Chemical Information

Molecular Weight 652.68
Formula C₃₄H₃₆F₄N₆O₃
SMILES

C#CCN1CCN(CC1)C(C2=CC=C(C(C3=CC(NC(C(C(C(F)(F)F)=C4)=CNC4=O)=O)=C(N5C[C@@H](N([C@@H](C5)C)C)C)C=C3)=C2)F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lu H, et al. Design, Synthesis and Biological Evaluation of Novel, Potent, Selective and Orally Available DGKα Inhibitors for the Treatment of Tumors. J Med Chem. 2025;68(23):25011-25025. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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