ANAPC2 - anaphase promoting complex subunit 2 Gene

Homo sapiens

Also known as APC2

Gene ID: 29882 | Gene type: protein coding

About ANAPC2

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:137,174,784-137,188,560 (from NCBI)

This gene has 8 transcripts (splice variants), 200 orthologues and 7 paralogues. Ubiquitous expression in testis (RPKM 16.5), spleen (RPKM 12.2) and 25 other tissues.

Summary

A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S Proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation. [provided by RefSeq, Jul 2008]

ANAPC2 Products(1)

mRNA	Protein	Name
NM_013366.4	NP_037498.1	anaphase-promoting complex subunit 2

ANAPC2 Protein Structure

Cullin

ANAPC2

0
200
400
600
822 a.a.

Protein Preferred Names

Protein Names

anaphase-promoting complex subunit 2

cyclosome subunit 2

Related Diseases

Diseases

Alias

Chondrodysplasia With Platyspondyly, Distinctive Brachydactyly, Hydrocephaly, And Microphthalmia

X-Linked Dominant Chondrodysplasia, Chassaing-Lacombe Type	X-Linked Dominant Chondrodysplasia-Hydrocephaly-Microphthalmia Syndrome
CDP-PBHM	Chondrodysplasia, With Platyspondyly, Distinctive Brachydactyly, Hydrocephaly, And Microphthalmia

Bardet-Biedl Syndrome 10

BBS10	Bardet-Biedl Syndrome
Bbs	Bardet-Biedl Syndrome, Type 10

Melnick-Needles Syndrome

MNS	Melnick-Needles Osteodysplasty
Osteodysplasty Of Melnick And Needles	Osteochondrodysplasias

Mosaic Variegated Aneuploidy Syndrome

Warburton-Anyane-Yeboa Syndrome	Mva Syndrome
Mosaic Variegated Aneuplody Microcephaly Syndrome	Warburton Anyane Yeboa Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00680	ANAPC2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ANAPC2	VGNC	VGNC:59775
Macaca mulatta	ANAPC2	VGNC	VGNC:69641
Mus musculus	ANAPC2	MGD	MGI:2139135
Bos taurus	ANAPC2	VGNC	VGNC:102815
Rattus norvegicus	ANAPC2	RGD	RGD:1305546
Canis familiaris	ANAPC2	VGNC	VGNC:37849

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