ANAPC2 - anaphase promoting complex subunit 2 Gene

Also Known as APC2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 29882

About ANAPC2

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:137,174,784-137,188,560 (from NCBI)

This gene has 8 transcripts (splice variants), 200 orthologues and 7 paralogues. Ubiquitous expression in testis (RPKM 16.5), spleen (RPKM 12.2) and 25 other tissues.

Summary

A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S Proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation. [provided by RefSeq, Jul 2008]

ANAPC2 Products (1)

mRNA	Protein	Name
NM_013366.4	NP_037498.1	anaphase-promoting complex subunit 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23708001	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in anaphase-promoting complex-dependent catabolic process	IDA IDA: Inferred from direct assay	29033132	GOA
involved in protein K11-linked ubiquitination	IDA IDA: Inferred from direct assay	18485873	GOA
involved in protein K48-linked ubiquitination	IDA IDA: Inferred from direct assay	29033132	GOA
involved in protein branched polyubiquitination	IDA IDA: Inferred from direct assay	29033132	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of anaphase-promoting complex	IDA IDA: Inferred from direct assay	16364912	GOA
part of anaphase-promoting complex	IPI IPI: Inferred from physical interaction	27120157	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANAPC2 Protein Structure

Cullin

ANAPC2

0
200
400
600
822 a.a.

Protein Preferred Names	Protein Names
anaphase-promoting complex subunit 2	cyclosome subunit 2

ANAPC2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ANAPC2	Q9UJX6	FBXO5	Homo sapiens	Q9UKT4-1	Ion Exchange Chrom	26083744
Intra	ANAPC2	Q9UJX6	FBXO5	Homo sapiens	Q9UKT4-1	GMS	26083744
Intra	ANAPC2	Q9UJX6	FBXO5	Homo sapiens	Q9UKT4-1	3D-EM	26083744
Intra	ANAPC2	Q9UJX6	MEOX1	Homo sapiens	P50221	Y2H Array	32296183
Intra	ANAPC2	Q9UJX6	MEOX1	Homo sapiens	P50221	Y2H Prey Pooling	32296183
Intra	ANAPC2	Q9UJX6	WDR5	Homo sapiens	P61964	Y2H Array	32296183
Intra	ANAPC2	Q9UJX6	WDR5	Homo sapiens	P61964	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Chondrodysplasia With Platyspondyly, Distinctive Brachydactyly, Hydrocephaly, And Microphthalmia	X-Linked Dominant Chondrodysplasia, Chassaing-Lacombe Type X-Linked Dominant Chondrodysplasia-Hydrocephaly-Microphthalmia Syndrome CDP-PBHM Chondrodysplasia, With Platyspondyly, Distinctive Brachydactyly, Hydrocephaly, And Microphthalmia
Bardet-Biedl Syndrome 10	BBS10 Bardet-Biedl Syndrome Bbs Bardet-Biedl Syndrome, Type 10
Melnick-Needles Syndrome	MNS Melnick-Needles Osteodysplasty Osteodysplasty Of Melnick And Needles Osteochondrodysplasias
Mosaic Variegated Aneuploidy Syndrome	Warburton-Anyane-Yeboa Syndrome Mva Syndrome Mosaic Variegated Aneuplody Microcephaly Syndrome Warburton Anyane Yeboa Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00680	ANAPC2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ANAPC2	VGNC	VGNC:59775
Macaca mulatta	ANAPC2	VGNC	VGNC:69641
Mus musculus	ANAPC2	MGD	MGI:2139135
Bos taurus	ANAPC2	VGNC	VGNC:102815
Rattus norvegicus	ANAPC2	RGD	RGD:1305546
Canis familiaris	ANAPC2	VGNC	VGNC:37849
Others	ANAPC2	NCBI