1. Epigenetics
  2. Histone Methyltransferase
  3. DDO-2093

DDO-2093 

Cat. No.: HY-132233
Handling Instructions

DDO-2093 is a potent MLL1-WDR5 protein-protein interaction inhibitor (IC50=8.6 nM; Kd=11.6 nM) with antitumor activity. DDO-2093 selectively inhibits the catalytic activity of MLL complex.

For research use only. We do not sell to patients.

DDO-2093 Chemical Structure

DDO-2093 Chemical Structure

CAS No. : 2250024-74-7

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Description

DDO-2093 is a potent MLL1-WDR5 protein-protein interaction inhibitor (IC50=8.6 nM; Kd=11.6 nM) with antitumor activity. DDO-2093 selectively inhibits the catalytic activity of MLL complex[1].

In Vitro

DDO-2093 (5 μM; pretreated 7 days) inhibits MLL-fusion protein dependent genes expression (HOXA9 and Meis1)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: MV4-11 cells
Concentration: 1, 2.5, 5, and 10 μM
Incubation Time: Pretreated 7 days
Result: Dose-dependently reduced the mono-, di-, and trimethylation of H3K4.
In Vivo

DDO-2093 (20 mg/kg-80 mg/kg; i.p.; every other day for 21 days) significantly suppresses the tumor size and weight in a dose-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female nude mice (MV4-11 human leukemia cancer xenografts)[1]
Dosage: 20 mg/kg, 40 mg/kg and 80 mg/kg
Administration: I.p.; every other day for 21 days
Result: The tumor volume growth inhibition (GI) values were calculated to be 13.7%, 37.6% and 63.9% with doses of 20 mg/kg, 40 mg/kg and 80 mg/kg, respectively.
Molecular Weight

614.11

Formula

C₂₉H₃₇ClFN₉O₃

CAS No.
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DDO-2093
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HY-132233
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