DDO-2093 dihydrochloride
Based on 1 Customer Validation
DDO-2093 dihydrochloride is a potent MLL1-WDR5 protein-protein interaction inhibitor (IC50=8.6 nM; Kd=11.6 nM) with antitumor activity. DDO-2093 dihydrochloride selectively inhibits the catalytic activity of MLL complex.
For research use only. We do not sell to patients.
- Purity: 98.79%
- Formula: C29H39Cl3FN9O3
- Molecular Weight:687.04
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Histone Methyltransferase Isoforms
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Biological Activity
DDO-2093 (5 μM; pretreated 7 days) dihydrochloride inhibits MLL-fusion protein dependent genes expression (HOXA9 and Meis1)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MV4-11 cells
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Concentration:1, 2.5, 5, and 10 μM
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Incubation Time:7 days
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Result:Dose-dependently reduced the mono-, di-, and trimethylation of H3K4.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female nude mice (MV4-11 human leukemia cancer xenografts)[1]
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Dosage:20, 40, and 80 mg/kg
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Administration:Intraperitoneal injection; every other day for 21 days
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Result:Had the tumor volume growth inhibition (GI) values were calculated to be 13.7%, 37.6% and 63.9% with doses of 20 mg/kg, 40 mg/kg and 80 mg/kg, respectively.
Chemical Information
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Appearance Solid
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Molecular Weight 687.04
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Formula C29H39Cl3FN9O3
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Color Off-white to light yellow
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SMILES
O=C(C1=CN(C2=CC=C(N3CCN(C)CC3)C(NC(C4=CC(N)=C(F)C(C)=C4Cl)=O)=C2)N=N1)NCCCN5CCOCC5.[H]Cl.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (145.55 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4555 mL | 7.2776 mL | 14.5552 mL | 36.3880 mL |
| 5 mM | 0.2911 mL | 1.4555 mL | 2.9110 mL | 7.2776 mL | |
| 10 mM | 0.1456 mL | 0.7278 mL | 1.4555 mL | 3.6388 mL | |
| 15 mM | 0.0970 mL | 0.4852 mL | 0.9703 mL | 2.4259 mL | |
| 20 mM | 0.0728 mL | 0.3639 mL | 0.7278 mL | 1.8194 mL | |
| 25 mM | 0.0582 mL | 0.2911 mL | 0.5822 mL | 1.4555 mL | |
| 30 mM | 0.0485 mL | 0.2426 mL | 0.4852 mL | 1.2129 mL | |
| 40 mM | 0.0364 mL | 0.1819 mL | 0.3639 mL | 0.9097 mL | |
| 50 mM | 0.0291 mL | 0.1456 mL | 0.2911 mL | 0.7278 mL | |
| 60 mM | 0.0243 mL | 0.1213 mL | 0.2426 mL | 0.6065 mL | |
| 80 mM | 0.0182 mL | 0.0910 mL | 0.1819 mL | 0.4548 mL | |
| 100 mM | 0.0146 mL | 0.0728 mL | 0.1456 mL | 0.3639 mL |
DDO-2093 dihydrochloride Related Classifications
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