2. Epigenetics
  3. Histone Methyltransferase
  4. DDO-2093 dihydrochloride

DDO-2093 dihydrochloride is a potent MLL1-WDR5 protein-protein interaction inhibitor (IC50=8.6 nM; Kd=11.6 nM) with antitumor activity. DDO-2093 dihydrochloride selectively inhibits the catalytic activity of MLL complex.

For research use only. We do not sell to patients.

DDO-2093 dihydrochloride Chemical Structure

DDO-2093 dihydrochloride Chemical Structure

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5 mg USD 580 In-stock
10 mg USD 1050 In-stock
25 mg USD 2250 In-stock
50 mg USD 3600 In-stock
100 mg USD 5800 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of DDO-2093 dihydrochloride:

DDO-2093 dihydrochloride Related Antibodies

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Description

DDO-2093 dihydrochloride is a potent MLL1-WDR5 protein-protein interaction inhibitor (IC50=8.6 nM; Kd=11.6 nM) with antitumor activity. DDO-2093 dihydrochloride selectively inhibits the catalytic activity of MLL complex[1].

In Vitro

DDO-2093 (5 μM; pretreated 7 days) dihydrochloride inhibits MLL-fusion protein dependent genes expression (HOXA9 and Meis1)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DDO-2093 dihydrochloride Related Antibodies

Western Blot Analysis[1]

Cell Line: MV4-11 cells
Concentration: 1, 2.5, 5, and 10 μM
Incubation Time: 7 days
Result: Dose-dependently reduced the mono-, di-, and trimethylation of H3K4.
In Vivo

DDO-2093 (20-80 mg/kg; i.p.; every other day for 21 days) dihydrochloride significantly suppresses the tumor size and weight in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female nude mice (MV4-11 human leukemia cancer xenografts)[1]
Dosage: 20, 40, and 80 mg/kg
Administration: Intraperitoneal injection; every other day for 21 days
Result: Had the tumor volume growth inhibition (GI) values were calculated to be 13.7%, 37.6% and 63.9% with doses of 20 mg/kg, 40 mg/kg and 80 mg/kg, respectively.
Molecular Weight

687.04

Formula

C29H39Cl3FN9O3
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=CN(C2=CC=C(N3CCN(C)CC3)C(NC(C4=CC(N)=C(F)C(C)=C4Cl)=O)=C2)N=N1)NCCCN5CCOCC5.[H]Cl.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (145.55 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4555 mL 7.2776 mL 14.5552 mL
5 mM 0.2911 mL 1.4555 mL 2.9110 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4555 mL 7.2776 mL 14.5552 mL 36.3880 mL
5 mM 0.2911 mL 1.4555 mL 2.9110 mL 7.2776 mL
10 mM 0.1456 mL 0.7278 mL 1.4555 mL 3.6388 mL
15 mM 0.0970 mL 0.4852 mL 0.9703 mL 2.4259 mL
20 mM 0.0728 mL 0.3639 mL 0.7278 mL 1.8194 mL
25 mM 0.0582 mL 0.2911 mL 0.5822 mL 1.4555 mL
30 mM 0.0485 mL 0.2426 mL 0.4852 mL 1.2129 mL
40 mM 0.0364 mL 0.1819 mL 0.3639 mL 0.9097 mL
50 mM 0.0291 mL 0.1456 mL 0.2911 mL 0.7278 mL
60 mM 0.0243 mL 0.1213 mL 0.2426 mL 0.6065 mL
80 mM 0.0182 mL 0.0910 mL 0.1819 mL 0.4548 mL
100 mM 0.0146 mL 0.0728 mL 0.1456 mL 0.3639 mL
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DDO-2093 dihydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DDO-2093DDO2093DDO 2093Histone MethyltransferaseMLL1WDR5antitumorcatalyticcomplexMV4-11leukemiacancerInhibitorinhibitorinhibit

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DDO-2093 dihydrochloride
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