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Cat. No.: HY-183959

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DC_M5_2

DC_M5_2 is a WD40 repeat domain protein 5 (WDR5) inhibitor with an IC₅₀ of 9.63 μM and a K_D of 13.8 μM. DC_M5_2 binds to the WDR5 pocket that interacts with the MLL1 peptide, blocking the WDR5-MLL1 protein-protein interaction. DC_M5_2 can be used in leukemia-related research.

For research use only. We do not sell to patients.

CAS No.: 713099-37-7
Formula: C₂₂H₂₂BrNO₅
Molecular Weight:460.32

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

DC_M5_2 Chemical Structure

CAS No.: 713099-37-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

DC_M5_2 is a WD40 repeat domain protein 5 (WDR5) inhibitor with an IC₅₀ of 9.63 μM and a K_D of 13.8 μM. DC_M5_2 binds to the WDR5 pocket that interacts with the MLL1 peptide, blocking the WDR5-MLL1 protein-protein interaction^[2]. DC_M5_2 can be used in leukemia-related research^[1]^[2].

In Vitro

DC_M5_2 inhibits the WDR5-MLL1 interaction with an IC₅₀ of 9.63 µM by binding to WDR5 through hydrophobic contacts and hydrogen bonds^[1].
DC_M5_2 binds directly to purified WDR5 protein in vitro with a K_d of 13.8 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 713099-37-7
Molecular Weight 460.32
Formula C₂₂H₂₂BrNO₅
SMILES

O=C(COC1=CC=C(C=C1C2C3=C(N(C)C4=C2C(CCC4)=O)CCCC3=O)Br)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Gurung R, et al. Recent Progress in Modulation of WD40-Repeat Domain 5 Protein (WDR5): Inhibitors and Degraders. Cancers (Basel). 2023;15(15):3910. Published 2023 Aug 1. [Content Brief]

[2]. Ye X, et al. The identification of novel small-molecule inhibitors targeting WDR5-MLL1 interaction through fluorescence polarization based high-throughput screening. Bioorg Med Chem Lett. 2019;29(4):638-645. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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