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MM-589 

Cat. No.: HY-100869
Handling Instructions

MM-589 is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) interaction. MM-589 binds to WDR5 with an IC50 of 0.90 nM and inhibits the MLL H3K4 methyltransferase activity with an IC50 of 12.7 nM.

For research use only. We do not sell to patients.

MM-589 Chemical Structure

MM-589 Chemical Structure

CAS No. : 2097887-20-0

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  • Biological Activity

  • Technical Information

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  • References

Description

MM-589 is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) interaction. MM-589 binds to WDR5 with an IC50 of 0.90 nM and inhibits the MLL H3K4 methyltransferase activity with an IC50 of 12.7 nM[1].

IC50 & Target

IC50: 0.90 nM (WDR5), 12.7 nM (HMT)[1]

Ki: <1 nM (WDR5)[1]

In Vitro

MM-589 binds to WDR5 with high affinity (IC50=0.90 nM, Ki <1 nM) and potently inhibits the MLL HMT activity (IC50=12.7 nM)[1].

MM-589 (0.01-10 µM, 4 days or 7 days) potently and selectively inhibits cell growth in human leukemia cell lines harboring MLL translocations[1].

Cell Viability Assay[1]

Cell Line: MV4-11 and MOLM-13
Concentration: 0.1, 1, 10 μM
Incubation Time: 4 days or 7 days
Result: MM-589 potently inhibits MV4-11 and MOLM-13 cell growth with IC50s of 0.25 and 0.21 μM, respectively. MM-589 has much weaker activity in the inhibition of cell growth of the HL-60 cell line with an IC50 of 8.6 μM[1].
In Vivo

MM-589 has excellent microsomal stability in human, mouse, and rat microsomes (T1/2 > 60 min). Further optimization of MM-589 may yield a new therapy for acute leukemia[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7461 mL 8.7306 mL 17.4611 mL
5 mM 0.3492 mL 1.7461 mL 3.4922 mL
10 mM 0.1746 mL 0.8731 mL 1.7461 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

572.70

Formula

C₂₈H₄₄N₈O₅

CAS No.

2097887-20-0

SMILES

O=C(NCC[[email protected]](NC(C(C)C)=O)(C)C1=O)[[email protected]](NC([[email protected]@H](NC([[email protected]](CCCNC(NC)=N)N1)=O)CC)=O)C2=CC=CC=C2

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
MM-589
Cat. No.:
HY-100869
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MM-589

Cat. No.: HY-100869