MM-589
MM-589 is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) protein-protein interaction. MM-589 binds to WDR5 with an IC50 of 0.90 nM and inhibits the MLL H3K4 methyltransferase activity with an IC50 of 12.7 nM.
At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (MM-589 TFA) usually boasts enhanced water solubility and stability.
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- CAS. Nr.: 2097887-20-0
- Formel: C28H44N8O5
- Molecular Weight:572.70
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Other In-stock Forms of MM-589
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
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Biologische Aktivität
Beschreibung
IC50 & Target
IC50: 0.90 nM (WDR5), 12.7 nM (HMT)[1]
Ki: <1 nM (WDR5)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MV4-11 | IC50 |
250 nM
Compound: MM-589
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Anti-proliferative activity against human MV4-11 cells harboring MLL-AF4 fusion protein assessed as cell growth inhibition treated for 4 days by WST-8 cell proliferation assay
Anti-proliferative activity against human MV4-11 cells harboring MLL-AF4 fusion protein assessed as cell growth inhibition treated for 4 days by WST-8 cell proliferation assay
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[PMID: 35436124] |
In Vitro
MM-589 (0.01-10 μM, 4 days or 7 days) potently and selectively inhibits cell growth in human leukemia cell lines harboring MLL translocations[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MV4-11 and MOLM-13 cells
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Concentration:0.01, 0.1, 1, 10 μM
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Incubation Time:4 days or 7 days
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Result:Potently inhibited MV4-11 and MOLM-13 cell growth with IC50s of 0.25 and 0.21 μM, respectively. Had much weaker activity in the inhibition of cell growth of the HL-60 cell line with an IC50 of 8.6 μM.
Chemical Information
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CAS. Nr. 2097887-20-0
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Molecular Weight 572.70
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Formel C28H44N8O5
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SMILES
O=C(NCC[C@](NC(C(C)C)=O)(C)C1=O)[C@H](NC([C@@H](NC([C@H](CCCNC(NC)=N)N1)=O)CC)=O)C2=CC=CC=C2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : ≥ 100 mg/mL (174.61 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Reinheit & Dokumentation
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Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7461 mL | 8.7306 mL | 17.4611 mL | 43.6529 mL |
| 5 mM | 0.3492 mL | 1.7461 mL | 3.4922 mL | 8.7306 mL | |
| 10 mM | 0.1746 mL | 0.8731 mL | 1.7461 mL | 4.3653 mL | |
| 15 mM | 0.1164 mL | 0.5820 mL | 1.1641 mL | 2.9102 mL | |
| 20 mM | 0.0873 mL | 0.4365 mL | 0.8731 mL | 2.1826 mL | |
| 25 mM | 0.0698 mL | 0.3492 mL | 0.6984 mL | 1.7461 mL | |
| 30 mM | 0.0582 mL | 0.2910 mL | 0.5820 mL | 1.4551 mL | |
| 40 mM | 0.0437 mL | 0.2183 mL | 0.4365 mL | 1.0913 mL | |
| 50 mM | 0.0349 mL | 0.1746 mL | 0.3492 mL | 0.8731 mL | |
| 60 mM | 0.0291 mL | 0.1455 mL | 0.2910 mL | 0.7275 mL | |
| 80 mM | 0.0218 mL | 0.1091 mL | 0.2183 mL | 0.5457 mL | |
| 100 mM | 0.0175 mL | 0.0873 mL | 0.1746 mL | 0.4365 mL |
MM-589 Related Classifications
HY-100869 Related Classifications
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