MM-589
MM-589 is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) protein-protein interaction. MM-589 binds to WDR5 with an IC50 of 0.90 nM and inhibits the MLL H3K4 methyltransferase activity with an IC50 of 12.7 nM.
For research use only. We do not sell to patients.
- CAS No.: 2097887-20-0
- Formula: C28H44N8O5
- Molecular Weight:572.70
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
IC50: 0.90 nM (WDR5), 12.7 nM (HMT)[1]
Ki: <1 nM (WDR5)[1]
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MV4-11 | IC50 |
250 nM
Compound: MM-589
|
Anti-proliferative activity against human MV4-11 cells harboring MLL-AF4 fusion protein assessed as cell growth inhibition treated for 4 days by WST-8 cell proliferation assay
Anti-proliferative activity against human MV4-11 cells harboring MLL-AF4 fusion protein assessed as cell growth inhibition treated for 4 days by WST-8 cell proliferation assay
|
[PMID: 35436124] |
MM-589 (0.01-10 μM, 4 days or 7 days) potently and selectively inhibits cell growth in human leukemia cell lines harboring MLL translocations[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:MV4-11 and MOLM-13 cells
-
Concentration:0.01, 0.1, 1, 10 μM
-
Incubation Time:4 days or 7 days
-
Result:Potently inhibited MV4-11 and MOLM-13 cell growth with IC50s of 0.25 and 0.21 μM, respectively. Had much weaker activity in the inhibition of cell growth of the HL-60 cell line with an IC50 of 8.6 μM.
Chemical Information
-
CAS No. 2097887-20-0
-
Molecular Weight 572.70
-
Formula C28H44N8O5
-
SMILES
O=C(NCC[C@](NC(C(C)C)=O)(C)C1=O)[C@H](NC([C@@H](NC([C@H](CCCNC(NC)=N)N1)=O)CC)=O)C2=CC=CC=C2
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
DMSO : ≥ 100 mg/mL (174.61 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7461 mL | 8.7306 mL | 17.4611 mL | 43.6529 mL |
| 5 mM | 0.3492 mL | 1.7461 mL | 3.4922 mL | 8.7306 mL | |
| 10 mM | 0.1746 mL | 0.8731 mL | 1.7461 mL | 4.3653 mL | |
| 15 mM | 0.1164 mL | 0.5820 mL | 1.1641 mL | 2.9102 mL | |
| 20 mM | 0.0873 mL | 0.4365 mL | 0.8731 mL | 2.1826 mL | |
| 25 mM | 0.0698 mL | 0.3492 mL | 0.6984 mL | 1.7461 mL | |
| 30 mM | 0.0582 mL | 0.2910 mL | 0.5820 mL | 1.4551 mL | |
| 40 mM | 0.0437 mL | 0.2183 mL | 0.4365 mL | 1.0913 mL | |
| 50 mM | 0.0349 mL | 0.1746 mL | 0.3492 mL | 0.8731 mL | |
| 60 mM | 0.0291 mL | 0.1455 mL | 0.2910 mL | 0.7275 mL | |
| 80 mM | 0.0218 mL | 0.1091 mL | 0.2183 mL | 0.5457 mL | |
| 100 mM | 0.0175 mL | 0.0873 mL | 0.1746 mL | 0.4365 mL |
Powered by Bioz