MM-589 (racemic mixture ) (TFA)

Name: MM-589 (racemic mixture ) (TFA)
Brand: MedChemExpress
SKU: HY-100869B
Rating: 4.5 (1 reviews)

Cat. No.: HY-100869B Purity: 99.83%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

MM-589 (racemic mixture) TFA, is a racemic mixture of MM-589 TFA (HY-100869A). MM-589 TFA is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) protein-protein interaction. MM-589 binds to WDR5 with an IC₅₀ of 0.90 nM and inhibits the MLL H3K4 methyltransferase activity with an IC₅₀ of 12.7 nM.

For research use only. We do not sell to patients.

MM-589 (racemic mixture ) (TFA) Chemical Structure

Size	Price	Stock	Quantity
1 mg	USD 310	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 780	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1250	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 2500	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of MM-589 (racemic mixture ) (TFA):

MM-589 TFA In-stock
MM-589 Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

IC50: 12.7 nM (H3K4 methyltransferase), 0.90 nM (WDR5)^[1]

Molecular Weight

686.72

Formula

C₃₀H₄₅F₃N₈O₇

Appearance

Solid

Color

White to off-white

SMILES

O=C(NCC[C@](NC(C(C)C)=O)(C)C1=O)[C@H](NC([C@@H](NC([C@H](CCCNC(NC)=N)N1)=O)CC)=O)C2=CC=CC=C2.O=C(NCC[C@](NC(C(C)C)=O)(C)C3=O)[C@@H](NC([C@@H](NC([C@H](CCCNC(NC)=N)N3)=O)CC)=O)C4=CC=CC=C4.OC(C(F)(F)F)=O.[(7:3)]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 40 mg/mL (58.25 mM; ultrasonic and adjust pH to 2 with 1M HCl)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4562 mL	7.2810 mL	14.5620 mL
5 mM	0.2912 mL	1.4562 mL	2.9124 mL
10 mM	0.1456 mL	0.7281 mL	1.4562 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.83%

Select Batch:

Data Sheet (274 KB) SDS (251 KB)

COA (254 KB) HNMR (395 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. Karatas H, et al. Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction. J Med Chem. 2017 Jun 22;60(12):4818-4839. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.4562 mL	7.2810 mL	14.5620 mL	36.4049 mL
	5 mM	0.2912 mL	1.4562 mL	2.9124 mL	7.2810 mL
	10 mM	0.1456 mL	0.7281 mL	1.4562 mL	3.6405 mL
	15 mM	0.0971 mL	0.4854 mL	0.9708 mL	2.4270 mL
	20 mM	0.0728 mL	0.3640 mL	0.7281 mL	1.8202 mL
	25 mM	0.0582 mL	0.2912 mL	0.5825 mL	1.4562 mL
	30 mM	0.0485 mL	0.2427 mL	0.4854 mL	1.2135 mL
	40 mM	0.0364 mL	0.1820 mL	0.3640 mL	0.9101 mL
	50 mM	0.0291 mL	0.1456 mL	0.2912 mL	0.7281 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.