MM-589 (racemic mixture ) TFA
Based on 1 Customer Validation
MM-589 (racemic mixture) TFA, is a racemic mixture of MM-589 TFA (HY-100869A). MM-589 TFA is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) protein-protein interaction. MM-589 binds to WDR5 with an IC50 of 0.90 nM and inhibits the MLL H3K4 methyltransferase activity with an IC50 of 12.7 nM.
For research use only. We do not sell to patients.
- Purity: 99.83%
- Formula: C30H45F3N8O7
- Molecular Weight:686.72
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 12.7 nM (H3K4 methyltransferase), 0.90 nM (WDR5)[1]
Chemical Information
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Appearance Solid
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Molecular Weight 686.72
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Formula C30H45F3N8O7
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Color White to off-white
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SMILES
O=C(NCC[C@](NC(C(C)C)=O)(C)C1=O)[C@H](NC([C@@H](NC([C@H](CCCNC(NC)=N)N1)=O)CC)=O)C2=CC=CC=C2.O=C(NCC[C@](NC(C(C)C)=O)(C)C3=O)[C@@H](NC([C@@H](NC([C@H](CCCNC(NC)=N)N3)=O)CC)=O)C4=CC=CC=C4.OC(C(F)(F)F)=O.[(7:3)]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 40 mg/mL (58.25 mM; ultrasonic and adjust pH to 2 with 1M HCl)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.4562 mL | 7.2810 mL | 14.5620 mL | 36.4049 mL |
| 5 mM | 0.2912 mL | 1.4562 mL | 2.9124 mL | 7.2810 mL | |
| 10 mM | 0.1456 mL | 0.7281 mL | 1.4562 mL | 3.6405 mL | |
| 15 mM | 0.0971 mL | 0.4854 mL | 0.9708 mL | 2.4270 mL | |
| 20 mM | 0.0728 mL | 0.3640 mL | 0.7281 mL | 1.8202 mL | |
| 25 mM | 0.0582 mL | 0.2912 mL | 0.5825 mL | 1.4562 mL | |
| 30 mM | 0.0485 mL | 0.2427 mL | 0.4854 mL | 1.2135 mL | |
| 40 mM | 0.0364 mL | 0.1820 mL | 0.3640 mL | 0.9101 mL | |
| 50 mM | 0.0291 mL | 0.1456 mL | 0.2912 mL | 0.7281 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
MM-589 (racemic mixture ) TFA Related Classifications
HY-100869B Related Classifications
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