2. Epigenetics
  3. WDR5
  4. WDR5-47

WDR5-MLL1 antagonist 1 (compound 47) is a compound optimized through protein crystal structure guidance. It has stronger antagonistic activity against WDR5-MLL interaction with a dissociation constant (Kd) of 0.3μM.

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WDR5-47

WDR5-47 Estructura química

No. CAS : 1422389-91-0

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WDR5-47 Related Antibodies

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Descripciòn

WDR5-MLL1 antagonist 1 (compound 47) is a compound optimized through protein crystal structure guidance. It has stronger antagonistic activity against WDR5-MLL interaction with a dissociation constant (Kd) of 0.3μM.

Peso molecular

406.84

Fòrmula

C19H20ClFN4O3
No. CAS
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(NC1=CC([N+]([O-])=O)=CC=C1N2CCN(C)CC2)C3=CC=C(F)C(C)=C3Cl
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

DMSO : 20.83 mg/mL (51.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4580 mL 12.2898 mL 24.5797 mL
5 mM 0.4916 mL 2.4580 mL 4.9159 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4580 mL 12.2898 mL 24.5797 mL 61.4492 mL
5 mM 0.4916 mL 2.4580 mL 4.9159 mL 12.2898 mL
10 mM 0.2458 mL 1.2290 mL 2.4580 mL 6.1449 mL
15 mM 0.1639 mL 0.8193 mL 1.6386 mL 4.0966 mL
20 mM 0.1229 mL 0.6145 mL 1.2290 mL 3.0725 mL
25 mM 0.0983 mL 0.4916 mL 0.9832 mL 2.4580 mL
30 mM 0.0819 mL 0.4097 mL 0.8193 mL 2.0483 mL
40 mM 0.0614 mL 0.3072 mL 0.6145 mL 1.5362 mL
50 mM 0.0492 mL 0.2458 mL 0.4916 mL 1.2290 mL
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WDR5-47 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WDR5-471422389-91-0WDR5WD repeat protein-5WD40 repeat domain protein 5Inhibitorinhibitorinhibit

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Nombre del producto:
WDR5-47
Cat. No.:
HY-157659
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