ZXDC - ZXD family zinc finger C Gene

Also Known as ZXDL

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79364

About ZXDC

Cytogenetic location: 3q21.3 Genomic coordinates (GRCh38): 3:126,437,601-126,475,891 (from NCBI)

This gene has 4 transcripts (splice variants), 306 orthologues and 14 paralogues. Ubiquitous expression in bone marrow (RPKM 13.7), spleen (RPKM 5.6) and 25 other tissues.

Summary

Enables C2H2 zinc finger domain binding activity; LRR domain binding activity; and transcription coactivator activity. Involved in positive regulation of transcription, DNA-templated. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

ZXDC Products (2)

mRNA Protein Name
NM_001040653.4 NP_001035743.1 zinc finger protein ZXDC isoform 2
NM_025112.5 NP_079388.3 zinc finger protein ZXDC isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables C2H2 zinc finger domain binding IPI
IPI: Inferred from physical interaction
17493635 GOA
enables LRR domain binding IPI
IPI: Inferred from physical interaction
16600381 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16600381 GOA
enables transcription coactivator activity IMP
IMP: Inferred from mutant phenotype
17493635 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
17696781 GOA
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
16600381 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZXDC Protein Structure

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (175 - 199)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (208 - 232)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (254 - 278)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (358 - 382)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (388 - 412)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (452 - 476)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 858 a.a.
Protein Preferred Names Protein Names

zinc finger protein ZXDC

  • SERH2790

ZXDC Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZXDC Q2QGD7 CBR4 Homo sapiens Q8N4T8
Validated Y2H
32296183
Intra
ZXDC Q2QGD7 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
Intra
ZXDC Q2QGD7 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
Intra
ZXDC Q2QGD7 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
Intra
ZXDC Q2QGD7 CIITA Homo sapiens P33076
Anti Bait CoIP
17493635
Intra
ZXDC Q2QGD7 ZXDA Homo sapiens P98168
Anti Bait CoIP
17493635
Intra
ZXDC Q2QGD7 MEPE Homo sapiens Q9NQ76
Validated Y2H
32296183
Intra
ZXDC Q2QGD7 PSEN2 Homo sapiens P49810
Validated Y2H
32814053
Intra
ZXDC Q2QGD7 PSEN2 Homo sapiens P49810
Y2H Pooling
32814053
Intra
ZXDC Q2QGD7 PSEN2 Homo sapiens P49810
Y2H Array
32814053
Intra
ZXDC Q2QGD7 HSPB1 Homo sapiens P04792
Validated Y2H
32814053
Intra
ZXDC Q2QGD7 HSPB1 Homo sapiens P04792
Y2H Pooling
32814053
Intra
ZXDC Q2QGD7 HSPB1 Homo sapiens P04792
Y2H Array
32814053
Intra
ZXDC Q2QGD7 RNF11 Homo sapiens Q9Y3C5
Validated Y2H
32814053
Intra
ZXDC Q2QGD7 RNF11 Homo sapiens Q9Y3C5
Y2H Pooling
32814053
Intra
ZXDC Q2QGD7 RNF11 Homo sapiens Q9Y3C5
Y2H Array
32814053
Intra
ZXDC Q2QGD7 PMP22 Homo sapiens A0A6Q8PF08
Y2H Array
32814053
Intra
ZXDC Q2QGD7 PMP22 Homo sapiens A0A6Q8PF08
Y2H Pooling
32814053
Intra
ZXDC Q2QGD7 PMP22 Homo sapiens A0A6Q8PF08
Validated Y2H
32814053
Intra
ZXDC Q2QGD7 TTR Homo sapiens P02766
Y2H Array
32814053
Intra
ZXDC Q2QGD7 TTR Homo sapiens P02766
Validated Y2H
32814053
Intra
ZXDC Q2QGD7 TTR Homo sapiens P02766
Y2H Pooling
32814053
Intra
ZXDC Q2QGD7 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
ZXDC Q2QGD7 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
ZXDC Q2QGD7 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
ZXDC Q2QGD7 ZMYND19 Homo sapiens Q96E35
Validated Y2H
32296183
Intra
ZXDC Q2QGD7 PRPS1 Homo sapiens P60891
Validated Y2H
32814053
Intra
ZXDC Q2QGD7 PRPS1 Homo sapiens P60891
Y2H Array
32814053
Intra
ZXDC Q2QGD7 PRPS1 Homo sapiens P60891
Y2H Pooling
32814053
Intra
ZXDC Q2QGD7 ATXN1 Homo sapiens P54253
Y2H Prey Pooling
23275563
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Microcephalic Osteodysplastic Primordial Dwarfism, Type Ii

  • Microcephalic Osteodysplastic Primordial Dwarfism Type Ii

  • Majewski Osteodysplastic Primordial Dwarfism Type Ii

  • MOPD2

  • Mopd Ii

  • Osteodysplastic Primordial Dwarfism Type Ii

  • Mopdii

  • Osteodysplastic Primordial Dwarfism Type 2

  • Osteodysplastic Primordial Dwarfism, Type Ii

  • Pcnt-Related Microcephalic Osteodysplastic Primordial Dwarfism

  • Microcephalic Osteodysplastic Primordial Dwarfism Type 2

  • Mopd 2

  • Microcephalic Osteodysplastic Primordial Dwarfism With Tooth Abnormalities

  • Mopd Type Ii

  • Microcephalic Osteodysplastic Primordial Dwarfism 2

  • Dwarfism, Primordial, Osteodysplastic, Microcephalic Type Ii
Moyamoya Disease 1

  • Moyamoya Disease

  • Spontaneous Occlusion Of The Circle Of Willis

  • Mymy

  • Progressive Intracranial Arterial Occlusion

  • Moyamoya Syndrome

  • MYMY1

  • Cerebrovascular Moyamoya Disease

  • Moya-Moya Disease

  • Progressive Intracranial Occlusive Arteropathy

  • Idiopathic Moyamoya Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16213 ZXDC Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ZXDC VGNC VGNC:82559
Bos taurus ZXDC VGNC VGNC:37392
Canis familiaris ZXDC VGNC VGNC:48867
Felis catus ZXDC VGNC VGNC:67391
Rattus norvegicus ZXDC RGD RGD:1561296
Mus musculus ZXDC MGD MGI:1933108
Others ZXDC NCBI