HCFC1 - host cell factor C1 Gene

Also Known as CFF; HCF; HCF1; HFC1; MRX3; VCAF; HCF-1; MAHCX; XLID3; PPP1R89

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3054

About HCFC1

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:153,947,557-153,971,818 (from NCBI)

This gene has 4 transcripts (splice variants), 158 orthologues, 10 paralogues and is associated with 5 phenotypes. Ubiquitous expression in bone marrow (RPKM 11.5), spleen (RPKM 8.5) and 25 other tissues.

Summary

This gene is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear coactivator is proteolytically cleaved at one of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains. The protein is involved in control of the cell cycle and transcriptional regulation during herpes simplex virus Infection. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

HCFC1 Products (2)

mRNA	Protein	Name
NM_001410705.1	NP_001397634.1	host cell factor 1 isoform 1
NM_005334.3	NP_005325.2	host cell factor 1 isoform 2

HCFC1 Protein Structure

Kelch_1

Kelch_3

0
400
800
1200
1600
2035 a.a.

Protein Preferred Names	Protein Names
host cell factor 1	VP16-accessory protein

HCFC1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HCFC1	P51610	FOXO3	Homo sapiens	O43524	Anti Tag CoIP	21909281
Intra	HCFC1	P51610	THAP11	Homo sapiens	Q96EK4	Pull Down	18585351
Intra	HCFC1	P51610	BAP1	Homo sapiens	Q92560	Anti Bait CoIP	24211834
Intra	HCFC1	P51610	SP1	Homo sapiens	P08047	Anti Tag CoIP	12670868
Intra	HCFC1	P51610	HDAC2	Homo sapiens	Q92769	Anti Tag CoIP	12670868
Intra	HCFC1	P51610	HDAC1	Homo sapiens	Q13547	Anti Tag CoIP	12670868
Intra	HCFC1	P51610	SIN3A	Homo sapiens	Q96ST3	Anti Tag CoIP	12670868
Intra	HCFC1	P51610	ZBTB17	Homo sapiens	Q13105	Pull Down	12244100
Intra	HCFC1	P51610	ZBTB17	Homo sapiens	Q13105	Y2H	12244100
Intra	HCFC1	P51610	CREBZF	Homo sapiens	Q9NS37	Y2H	10871379
Intra	HCFC1	P51610	CREBZF	Homo sapiens	Q9NS37	Transcription Compl	10871379
Intra	HCFC1	P51610	WDR5	Homo sapiens	P61964	Anti Tag CoIP	12670868
Intra	HCFC1	P51610	CREB3	Homo sapiens	O43889	Biophysical	10629049
Intra	HCFC1	P51610	CREB3	Homo sapiens	O43889	Pull Down	15705566
Intra	HCFC1	P51610	CREB3	Homo sapiens	O43889	Transcription Compl	10871379
Intra	HCFC1	P51610	CREBZF	Homo sapiens	Q9NS37	Pull Down	10871379
Intra	HCFC1	P51610	ASH2L	Homo sapiens	Q9UBL3	Anti Tag CoIP	12670868
Intra	HCFC1	P51610	OGT	Homo sapiens	O15294	Protease Assay	21295698
Intra	HCFC1	P51610	OGT	Homo sapiens	O15294	Anti Bait CoIP	21295698
Intra	HCFC1	P51610	OGT	Homo sapiens	O15294	Anti Tag CoIP	12670868
Intra	HCFC1	P51610	SUDS3	Homo sapiens	Q9H7L9	Anti Tag CoIP	12670868
Intra	HCFC1	P51610	SETD1A	Homo sapiens	O15047	Anti Tag CoIP	12670868
Intra	HCFC1	P51610	GABPB1	Homo sapiens	Q06547	Pull Down	10675337
Intra	HCFC1	P51610	GABPB1	Homo sapiens	Q06547-2	Y2H	10675337
Intra	HCFC1	P51610	GABPB1	Homo sapiens	Q06547-2	Pull Down	10675337
Intra	HCFC1	P51610	CREB3	Homo sapiens	O43889-2	Y2H	9271389
Intra	HCFC1	P51610	CREB3	Homo sapiens	O43889-2	Pull Down	18391022
Intra	HCFC1	P51610	GABPA	Homo sapiens	Q06546	Pull Down	10675337
Intra	HCFC1	P51610	THAP1	Homo sapiens	Q9NVV9	CH-IP	28486698

Cross: Cross-species interaction Intra: Intraspecies interaction

HCFC1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811022	HCFC1 Antibody	WB, IHC-P	Human, Mouse
HY-P89838	HCF1 Antibody (YA9182)	WB, ICC/IF, IF-Tissue, IHC-P, IP, ELISA	human, mouse, rat

Related Diseases

Diseases	Alias
Methylmalonic Aciduria And Homocystinuria, Cblx Type	Mental Retardation, X-Linked 3 Methylmalonic Acidemia With Homocystinuria, Type Cblx MAHCX Intellectual Developmental Disorder, X-Linked 3 Xlid3 Mrx3 Methylmalonic Acidemia And Homocysteinemia Cblx Type Combined Defect In Adenosylcobalamin And Methylcobalamin Synthesis, Type Cblx Methylmalonic Aciduria With Homocystinuria, Type Cblx Methylmalonic Acidemia And Homocysteinemia, Cblx Type Methylmalonic Aciduria And Homocysteinemia, Cblx Type Methylmalonic Aciduria And Homocysteinemia , Cblx Type Mental Retardation, X-Linked, Type 3
Methylmalonic Aciduria And Homocystinuria, Cblc Type	MAHCC Vitamin B12 Metabolic Defect With Combined Deficiency Of Methylmalonyl-Coa Mutase And Homocysteine:Methyltetrahydrofolate Methyltransferase Methylmalonic Aciduria And Homocystinuria, Cblc Type, Digenic Methylmalonic Aciduria And Homocystinuria Type Cblc Cobalamin C Disease Methylmalonic Acidemia With Homocystinuria Cblc Methylmalonic Acidemia And Homocystinuria, Cblc Type Methylmalonic Aciduria And Homocystinuria, Vitamin B12-Responsive Cobalamin C Deficiency Methylmalonic Acidemia With Homocystinuria, Type Cblc Cblc Defect Cobalamin C Defect Combined Defect In Adenosylcobalamin And Methylcobalamin Synthesis, Type Cblc Methylmalonic Aciduria With Homocystinuria, Type Cblc Methylmalonic Acidemia And Homocystinuria Cblc Type Methylmalonic Aciduria And Homocystinuria Vitamin B12-Responsive Aciduria, Methylmalonic, And Homocystinuria, Cblc Type Methylmalonic Acidemia With Homocystinuria
Non-Syndromic X-Linked Intellectual Disability	X-Linked Non-Syndromic Intellectual Disability Non-Specific X-Linked Mental Retardation X-Linked Non-Specific Intellectual Disability
Disorders Of Intracellular Cobalamin Metabolism
Herpes Simplex	Herpes Simplex Infections Herpesvirus Hominis Disease Herpes Simplex Disease Herpesviral Infection Due To Herpes Simplex Infections Due To Simplex Virus Herpes Nos
Non-Syndromic X-Linked Intellectual Disability 1	Mrx1 Mrx18 Mrx78 X-Linked Mental Retardation 1/78 X-Linked Mental Retardation 18
American Histoplasmosis	Infection By Histoplasma Capsulatum
Malignant Pleural Mesothelioma	Malignant Mesothelioma Of Pleura Pleural Malignant Mesothelioma
Dengue Disease	Dengue Fever Dengue Df Dengue Shock Syndrome Dengue Virus Infection Breakbone Fever Classic Dengue Classical Dengue Dengue Hemorrhagic Fever Hemorrhagic Dengue Philippine Hemorrhagic Fever Singapore Hemorrhagic Fever Thai Hemorrhagic Fever Severe Dengue Dengue Fever Without Warning Signs Dengue Haemorrhagic Fever Grade 1 Dengue Haemorrhagic Fever Without Warning Signs Bangkok Haemorrhagic Fever Singapore Haemorrhagic Fever Thailand Haemorrhagic Fever Southeast Asia Haemorrhagic Fever Dhf -[Dengue Haemorrhagic Fever] Dengue Fever With Warning Signs Dengue Haemorrhagic Fever With Warning Signs Dengue Haemorrhagic Fever Grade 2 Philippine Haemorrhagic Fever
Non-Syndromic X-Linked Intellectual Disability 2	Mrx2
Waisman Syndrome	Early-Onset Parkinsonism-Intellectual Disability Syndrome Bgmr Wsn Laxova-Opitz Syndrome WSMN Parkinsonism, Early-Onset, With Mental Retardation Basal Ganglion Disorder With Mental Retardation Basal Ganglia Disorder With Intellectual Disability Laxova Brown Hogan Syndrome X-Linked Recessive Basal Ganglia Disorder With Intellectual Disability
African Histoplasmosis
Homocystinuria	Cystathionine Beta Synthase Deficiency Homocysteinemia Cbs Deficiency Cystathionine Synthase Deficiency Cystathionine Beta-Synthase Deficiency Disease
Holoprosencephaly 1	Arhinencephaly HPE1 Cyclopia Holoprosencephaly, Familial Alobar Hpe, Familial Hpec Demyer Sequence Holoprosencephaly-1
Dystonia	Dystonic Disease Dystonic Disorder Dystonia Disorders Neuroleptic Dyskinesia
Cardiomyopathy, Familial Hypertrophic, 1	Asymmetric Septal Hypertrophy Familial Hypertrophic Cardiomyopathy Hypertrophic Cardiomyopathy 1 CMH1 Hypertrophic Cardiomyopathy 19 CMH Ventricular Hypertrophy, Hereditary Ash Hypertrophic Subaortic Stenosis, Idiopathic Cardiomyopathy, Familial Hypertrophic Cardiomyopathy, Hypertrophic, 1, Digenic Cardiomyopathy, Familial Hypertrophic 1 Hcm Hereditary Ventricular Hypertrophy Idiopathic Hypertrophic Subaortic Stenosis Hypertrophic Cardiomyopathy Cardiomyopathy, Hypertrophic, Familial Cardiomyopathy, Hypertrophic, 1 Familial Asymmetric Septal Hypertrophy Heritable Hypertrophic Cardiomyopathy Fhc Cardiomyopathy, Hypertrophic, Familial, Type 1
Melanoma, Uveal	Uveal Melanoma Choroidal Melanoma Melanoma Of Uvea Iris Melanoma Malignant Melanoma Of Choroid Malignant Melanoma Of Iris
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06042	HCFC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174788	HHV-1 UL48 mRNA		/	Unkown
HY-RS19688	Hcfc1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26182	Hcfc1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	HCFC1	VGNC	VGNC:73352
Felis catus	HCFC1	VGNC	VGNC:67541
Mus musculus	HCFC1	MGD	MGI:105942
Rattus norvegicus	HCFC1	RGD	RGD:1563804
Canis familiaris	HCFC1	VGNC	VGNC:41615
Bos taurus	HCFC1	VGNC	VGNC:29771
Others	HCFC1	NCBI