SIN3A - SIN3 transcription regulator family member A Gene

Homo sapiens

Also known as WITKOS

Gene ID: 25942 | Gene type: protein coding

About SIN3A

Cytogenetic location: 15q24.2 Genomic coordinates (GRCh38): 15:75,369,379-75,455,815 (from NCBI)

This gene has 21 transcripts (splice variants), 274 orthologues, 1 paralogue and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 15.9), thyroid (RPKM 12.9) and 25 other tissues.

Summary

The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex. [provided by RefSeq, Jul 2008]

SIN3A Products(3)

mRNA	Protein	Name
NM_001145357.2	NP_001138829.1	paired amphipathic helix protein Sin3a
NM_001145358.2	NP_001138830.1	paired amphipathic helix protein Sin3a
NM_015477.3	NP_056292.1	paired amphipathic helix protein Sin3a

SIN3A Protein Structure

PAH

Sin3_corepress

0
200
400
600
800
1000
1200
1273 a.a.

Protein Preferred Names

Protein Names

paired amphipathic helix protein Sin3a

SIN3 homolog A, transcription regulator

Related Diseases

Diseases

Alias

Witteveen-Kolk Syndrome

WITKOS	Sin3a-Related Intellectual Disability Syndrome Due To A Point Mutation
Sin3a-Related Intellectual Disability Syndrome

Chromosome 15q24 Deletion Syndrome

15q24 Microdeletion Syndrome	Del(15)(Q24)
Monosomy 15q24	15q24 Microdeletion
15q24 Deletion	Interstitial Deletion Of Chromosome 15q24

Rett Syndrome

Atypical Rett Syndrome	RTT
Rett Disorder	Rts
Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use	Rett Syndrome, Preserved Speech Variant
Rett Syndrome, Atypical	Rett'S Disorder
Rett Syndrome Variant	Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome
Cerebroatrophic Hyperammonemia	Rett Like Syndrome
Rett'S Syndrome	Atypical Rtt
Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use	Rett Syndrome Preserved Speech Variant
Rett Syndrome Zappella Variant	Rett Syndrome, Zappella Variant

Gene Duplication Disease

Gene Duplication Syndrome

Retinoblastoma

RB	Trilateral Retinoblastoma
RB1	Retinoblastoma, Trilateral
Neuroblastoma Of Retina	Rb - Retinoblastoma
Eye Cancer, Retinoblastoma	Retinal Cancer
Retinal Tumor	Glioma, Retinal
Non-Hereditary Retinoblastoma	Childhood Cancer Retinoblastoma
Malignant Neoplasm Of Retina	Retinal Neoplasms

Uterine Corpus Endometrial Carcinoma

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic	Acute Myeloblastic Leukemia Type 3
Aml M3	APL
Leukemia, Acute Promyelocytic, Somatic	Aml With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Apml
Acute Myeloblastic Leukemia 3	Acute Myeloid Leukemia With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Acute Myeloblastic Leukaemia Type 3
Acute Myeloid Leukaemia M3	Acute Myeloid Leukemia M3
Acute Promyelocytic Leukaemia	M3 Anll
Myeloid Leukemia, Acute, M3	Leukemia Promyelocytic Acute
Leukemia, Promyelocytic, Acute	Leukemia, Acute, Promyelocytic

Polymicrogyria

Pmg

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12925	SIN3A Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SIN3A	VGNC	VGNC:46177
Rattus norvegicus	SIN3A	RGD	RGD:1311598
Felis catus	SIN3A	VGNC	VGNC:65150
Macaca mulatta	SIN3A	VGNC	VGNC:77275
Mus musculus	SIN3A	MGD	MGI:107157
Bos taurus	SIN3A	VGNC	VGNC:34624

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