SIN3A - SIN3 transcription regulator family member A Gene

Also Known as WITKOS

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 25942

About SIN3A

Cytogenetic location: 15q24.2 Genomic coordinates (GRCh38): 15:75,369,379-75,455,815 (from NCBI)

This gene has 21 transcripts (splice variants), 274 orthologues, 1 paralogue and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 15.9), thyroid (RPKM 12.9) and 25 other tissues.

Summary

The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex. [provided by RefSeq, Jul 2008]

SIN3A Products (3)

mRNA Protein Name
NM_001145357.2 NP_001138829.1 paired amphipathic helix protein Sin3a
NM_001145358.2 NP_001138830.1 paired amphipathic helix protein Sin3a
NM_015477.3 NP_056292.1 paired amphipathic helix protein Sin3a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
22783022 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9651585 GOA
enables transcription corepressor activity IMP
IMP: Inferred from mutant phenotype
22783022 GOA
enables transcription regulator inhibitor activity IDA
IDA: Inferred from direct assay
22783022 GOA
Biological Process GO Annotation Evidence References Source
involved in activation of innate immune response IMP
IMP: Inferred from mutant phenotype
22783022 GOA
involved in heterochromatin formation IMP
IMP: Inferred from mutant phenotype
22783022 GOA
involved in negative regulation of protein localization to nucleus IMP
IMP: Inferred from mutant phenotype
22783022 GOA
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
22783022 GOA
involved in positive regulation of defense response to virus by host IMP
IMP: Inferred from mutant phenotype
22783022 GOA
involved in type I interferon-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
22783022 GOA
Cellular Component GO Annotation Evidence References Source
part of Sin3-type complex IDA
IDA: Inferred from direct assay
14966270 GOA
part of histone deacetylase complex IDA
IDA: Inferred from direct assay
9651585 GOA
located in nucleus IDA
IDA: Inferred from direct assay
22783022 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIN3A Protein Structure

PAH

PAH: Paired amphipathic helix repeat (141 - 187)

PAH

PAH: Paired amphipathic helix repeat (322 - 381)

PAH

PAH: Paired amphipathic helix repeat (478 - 522)

Sin3_corepress

Sin3_corepress: Sin3 family co-repressor (550 - 649)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1200
  • 1273 a.a.
Protein Preferred Names Protein Names

paired amphipathic helix protein Sin3a

  • SIN3 homolog A, transcription regulator

SIN3A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SIN3A Q96ST3 HDAC2 Homo sapiens Q92769
Anti Bait CoIP
25314079
Intra
SIN3A Q96ST3 HDAC2 Homo sapiens Q92769
Pull Down
16254079
Intra
SIN3A Q96ST3 HDAC1 Homo sapiens Q13547
Anti Tag CoIP
33961781
Intra
SIN3A Q96ST3 HDAC1 Homo sapiens Q13547
Anti Bait CoIP
25314079
Intra
SIN3A Q96ST3 HDAC1 Homo sapiens Q13547
Anti Bait CoIP
21258344
Intra
SIN3A Q96ST3 SKI Homo sapiens P12755
CoIP
14525983
Intra
SIN3A Q96ST3 SKI Homo sapiens P12755
Pull Down
10049357
Intra
SIN3A Q96ST3 SFPQ Homo sapiens P23246
Anti Bait CoIP
11259580
Intra
SIN3A Q96ST3 HCFC1 Homo sapiens P51610
Anti Bait CoIP
12670868
Intra
SIN3A Q96ST3 HCFC1 Homo sapiens P51610
Anti Tag CoIP
12670868
Intra
SIN3A Q96ST3 HCFC1 Homo sapiens P51610
Y2H
12670868
Intra
SIN3A Q96ST3 HTT Homo sapiens P42858
Pull Down
10823891
Intra
SIN3A Q96ST3 PA2G4 Homo sapiens Q9UQ80
Pull Down
16254079
Cross: Cross-species interaction Intra: Intraspecies interaction

SIN3A Antibodies

Cat. No. Product Name Application Reactivity
HY-P83623 mSin3A Antibody (YA3368) WB, IHC-P, ICC/IF, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Witteveen-Kolk Syndrome

  • WITKOS

  • Sin3a-Related Intellectual Disability Syndrome Due To A Point Mutation

  • Sin3a-Related Intellectual Disability Syndrome
Chromosome 15q24 Deletion Syndrome

  • 15q24 Microdeletion Syndrome

  • Del(15)(Q24)

  • Monosomy 15q24

  • 15q24 Microdeletion

  • 15q24 Deletion

  • Interstitial Deletion Of Chromosome 15q24
Rett Syndrome

  • Atypical Rett Syndrome

  • RTT

  • Rett Disorder

  • Rts

  • Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use

  • Rett Syndrome, Preserved Speech Variant

  • Rett Syndrome, Atypical

  • Rett'S Disorder

  • Rett Syndrome Variant

  • Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome

  • Cerebroatrophic Hyperammonemia

  • Rett Like Syndrome

  • Rett'S Syndrome

  • Atypical Rtt

  • Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use

  • Rett Syndrome Preserved Speech Variant

  • Rett Syndrome Zappella Variant

  • Rett Syndrome, Zappella Variant
Gene Duplication Disease

  • Gene Duplication Syndrome
Retinoblastoma

  • RB

  • Trilateral Retinoblastoma

  • RB1

  • Retinoblastoma, Trilateral

  • Neuroblastoma Of Retina

  • Rb - Retinoblastoma

  • Eye Cancer, Retinoblastoma

  • Retinal Cancer

  • Retinal Tumor

  • Glioma, Retinal

  • Non-Hereditary Retinoblastoma

  • Childhood Cancer Retinoblastoma

  • Malignant Neoplasm Of Retina

  • Retinal Neoplasms
Uterine Corpus Endometrial Carcinoma
Acute Promyelocytic Leukemia

  • Leukemia, Acute Promyelocytic

  • Acute Myeloblastic Leukemia Type 3

  • Aml M3

  • APL

  • Leukemia, Acute Promyelocytic, Somatic

  • Aml With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Apml

  • Acute Myeloblastic Leukemia 3

  • Acute Myeloid Leukemia With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Acute Myeloblastic Leukaemia Type 3

  • Acute Myeloid Leukaemia M3

  • Acute Myeloid Leukemia M3

  • Acute Promyelocytic Leukaemia

  • M3 Anll

  • Myeloid Leukemia, Acute, M3

  • Leukemia Promyelocytic Acute

  • Leukemia, Promyelocytic, Acute

  • Leukemia, Acute, Promyelocytic
Polymicrogyria

  • Pmg
Autism

  • Autistic Disorder

  • Autism Susceptibility 1

  • Childhood Autism

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Kanner'S Syndrome

  • Autistic
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P3242 Mad1 (6-21) 98.02% Unkown
HY-RS12925 SIN3A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P3242A Mad1 (6-21) TFA / Unkown
HY-RS20104 Sin3a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26607 Sin3a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SIN3A VGNC VGNC:46177
Rattus norvegicus SIN3A RGD RGD:1311598
Felis catus SIN3A VGNC VGNC:65150
Macaca mulatta SIN3A VGNC VGNC:77275
Mus musculus SIN3A MGD MGI:107157
Bos taurus SIN3A VGNC VGNC:34624
Others SIN3A NCBI