1. Cell Cycle/DNA Damage
    Epigenetics
    PROTAC
  2. HDAC
    PROTACs
  3. JPS014

JPS014 

Cat. No.: HY-145815
Handling Instructions

JPS014 is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC). JPS014 degrades class I histone deacetylase (HDAC). JPS014 is potent HDAC1/2 degrader correlated with greater total differentially expressed genes and enhanced apoptosis in HCT116 cells.

For research use only. We do not sell to patients.

JPS014 Chemical Structure

JPS014 Chemical Structure

CAS No. : 2669785-76-4

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Description

JPS014 is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC). JPS014 degrades class I histone deacetylase (HDAC). JPS014 is potent HDAC1/2 degrader correlated with greater total differentially expressed genes and enhanced apoptosis in HCT116 cells[1].

Molecular Weight

854.07

Formula

C46H59N7O7S

CAS No.
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JPS014
Cat. No.:
HY-145815
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