OGT - O-linked N-acetylglucosamine (GlcNAc) transferase Gene

Also Known as OGT1; HRNT1; MRX106; XLID106; HINCUT-1; O-GLCNAC

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8473

About OGT

Cytogenetic location: Xq13.1 Genomic coordinates (GRCh38): X:71,533,104-71,575,892 (from NCBI)

This gene has 21 transcripts (splice variants), 263 orthologues, 14 paralogues and is associated with 3 phenotypes. Ubiquitous expression in lymph node (RPKM 56.6), spleen (RPKM 53.1) and 25 other tissues.

Summary

This gene encodes a Glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains multiple tetratricopeptide repeats that are required for optimal recognition of substrates. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

OGT Products (2)

mRNA	Protein	Name
NM_181672.3	NP_858058.1	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 1
NM_181673.3	NP_858059.1	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables phosphatidylinositol-3,4,5-trisphosphate binding	IDA IDA: Inferred from direct assay	18288188	GOA
enables protein O-acetylglucosaminyltransferase activity	EXP EXP: Inferred from Experiment	30770249	GOA
enables protein O-acetylglucosaminyltransferase activity	IDA IDA: Inferred from direct assay	21285374	GOA
enables protein O-acetylglucosaminyltransferase activity	IMP IMP: Inferred from mutant phenotype	23777819	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12150998	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in apoptotic process	IDA IDA: Inferred from direct assay	20824293	GOA
involved in cellular response to glucose stimulus	IDA IDA: Inferred from direct assay	37541260	GOA
involved in negative regulation of non-canonical inflammasome complex assembly	IDA IDA: Inferred from direct assay	37962578	GOA
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	26678539	GOA
involved in negative regulation of protein ubiquitination	IMP IMP: Inferred from mutant phenotype	26678539	GOA
involved in positive regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	37541260	GOA
involved in positive regulation of proteolysis	IDA IDA: Inferred from direct assay	21285374	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	23222540	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	23352454	GOA
involved in positive regulation of translation	IDA IDA: Inferred from direct assay	34074792	GOA
involved in protein O-linked glycosylation	IDA IDA: Inferred from direct assay	21240259	GOA
involved in protein O-linked glycosylation	IMP IMP: Inferred from mutant phenotype	23353889	GOA
involved in protein processing	IMP IMP: Inferred from mutant phenotype	28584052	GOA
involved in regulation of Rac protein signal transduction	IDA IDA: Inferred from direct assay	18288188	GOA
involved in regulation of glycolytic process	IDA IDA: Inferred from direct assay	22923583	GOA
involved in regulation of insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	18288188	GOA
involved in regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	26678539	GOA
involved in response to insulin	IDA IDA: Inferred from direct assay	18288188	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of NSL complex	IDA IDA: Inferred from direct assay	20018852	GOA
located in cytosol	IDA IDA: Inferred from direct assay	21285374	GOA
part of histone acetyltransferase complex	IDA IDA: Inferred from direct assay	20018852	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21285374	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	18288188	GOA
part of protein N-acetylglucosaminyltransferase complex	IDA IDA: Inferred from direct assay	21240259	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	26678539	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OGT Protein Structure

TPR_11

TPR_1

TPR_11

Glyco_transf_41

0
200
400
600
800
1000
1046 a.a.

Protein Preferred Names	Protein Names
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit	O-GlcNAc transferase p110 subunit

OGT Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	OGT	O15294	TET2	Homo sapiens	E7EQS8	Y2H Prey Pooling	25416956
Intra	OGT	O15294	TET2	Homo sapiens	E7EQS8	Validated Y2H	25416956
Intra	OGT	O15294	TRAK1	Homo sapiens	Q9UPV9	TAP	27705803
Intra	OGT	O15294	PHC3	Homo sapiens	Q8NDX5	Y2H Prey Pooling	25416956
Intra	OGT	O15294	PHC3	Homo sapiens	Q8NDX5	Y2H Array	25416956
Intra	OGT	O15294	TET2	Homo sapiens	Q6N021-1	Pull Down	23222540
Intra	OGT	O15294	TET3	Homo sapiens	O43151	Pull Down	23353889
Intra	OGT	O15294	TET3	Homo sapiens	O43151	Pull Down	23222540
Intra	OGT	O15294	TET2	Homo sapiens	Q6N021	Anti Bait CoIP	23353889
Intra	OGT	O15294	TET2	Homo sapiens	Q6N021	Pull Down	23353889
Intra	OGT	O15294	PPP1CC	Homo sapiens	P36873	Anti Bait CoIP	27505673
Intra	OGT	O15294	URI1	Homo sapiens	O94763	Anti Bait CoIP	27505673
Intra	OGT	O15294	URI1	Homo sapiens	O94763	Pull Down	27505673
Intra	OGT	O15294	URI1	Homo sapiens	O94763	Enzymatic Study	27505673
Intra	OGT	O15294	URI1	Homo sapiens	O94763	Anti Tag CoIP	27505673
Intra	OGT	O15294	TAB1	Homo sapiens	Q15750	Enzymatic Study	27505673
Cross	OGT	O15294	Hoxa1	Mus musculus	P09022	BiFC	23088713
Cross	OGT	O15294	Hoxa1	Mus musculus	P09022	Y2H	23088713
Intra	OGT	O15294	HCFC1	Homo sapiens	P51610	TAP	27705803
Intra	OGT	O15294	HCFC1	Homo sapiens	P51610	Protease Assay	21295698
Intra	OGT	O15294	SNAP29	Homo sapiens	O95721	Pull Down	25419848
Intra	OGT	O15294	SNAP29	Homo sapiens	O95721	Anti Tag CoIP	25419848
Intra	OGT	O15294	NFATC1	Homo sapiens	O95644	Anti Bait CoIP	17882263
Intra	OGT	O15294	PSG1	Homo sapiens	P11464	Y2H Prey Pooling	25416956
Intra	OGT	O15294	PSG1	Homo sapiens	P11464	Validated Y2H	25416956
Intra	OGT	O15294	RELA	Homo sapiens	Q04206	Anti Bait CoIP	17882263
Intra	OGT	O15294	NUP62CL	Homo sapiens	Q9H1M0	Y2H Prey Pooling	25416956
Intra	OGT	O15294	NUP62CL	Homo sapiens	Q9H1M0	Y2H Pooling	16189514
Cross	OGT	O15294	Tet3	Mus musculus	Q8BG87	Pull Down	23353889
Cross	OGT	O15294	Tet3	Mus musculus	Q8BG87	Anti Tag CoIP	23353889
Cross	OGT	O15294	Ppp1cc	Rattus norvegicus	P63088	Pull Down	27505673

Cross: Cross-species interaction Intra: Intraspecies interaction

OGT Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80254	OGT Antibody (YA257)	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Intellectual Developmental Disorder, X-Linked 106	XLID106 Mrx106 Mental Retardation, X-Linked 106 Mental Retardation, X-Linked, Type 106
Myoepithelioma	Benign Myoepithelioma Myoepithelial Adenoma Myoepithelial Neoplasm Malignant Myoepithelioma
Bainbridge-Ropers Syndrome	BRPS Severe Feeding Difficulties-Failure To Thrive-Microcephaly Due To Asxl3 Deficiency Syndrome Asxl3-Related Disorder
Adams-Oliver Syndrome	Adams Oliver Syndrome Aos Congenital Scalp Defects With Distal Limb Reduction Anomalies Aplasia Cutis Congenita With Terminal Transverse Limb Defects Congenital Scalp Defects With Distal Limb Anomalies Limb, Scalp And Skull Defects Limb Scalp And Skull Defects Absence Defect Of Limbs, Scalp, And Skull
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (18)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-119738	OSMI-1	Inhibitor	99.88%	Unkown
HY-145934	UDP-GalNAz disodium	Substrate	99.89%	Unkown
HY-114361	OSMI-4	Inhibitor	99.69%	Unkown
HY-112174	UDP-GlcNAc disodium		99.92%	Unkown
HY-145934A	UDP-GlcNAz disodium	Substrate	99.74%	Unkown
HY-136282	ST045849	Inhibitor	99.96%	Unkown
HY-N3677	Dammarenediol II	Inhibitor	99.81%	Unkown
HY-101548	OGT-IN-1	Inhibitor	98.14%	Unkown
HY-139793	UDP-glucosamine disodium		99.44%	Unkown
HY-135784	OSMI-2	Inhibitor	99.59%	Unkown
HY-W039939	2-Azido-2-deoxy-D-glucose, 98%	Substrate	98.0%	Unkown
HY-119738A	(Rac)-OSMI-1	Inhibitor	96.51%	Unkown
HY-148113	PG 34		98.0%	Unkown
HY-125278	OGT-IN-4	Inhibitor	99.65%	Unkown
HY-145934B	UDP-GlcNAz	Substrate	/	Unkown
HY-135785	OSMI-3	Inhibitor	99.08%	Unkown
HY-149552	Ac4-5SGlcNAc	Inhibitor	/	Unkown
HY-W477597	BZX2	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	OGT	MGD	MGI:1339639
Rattus norvegicus	OGT	RGD	RGD:62060
Others	OGT	NCBI