OGT - O-linked N-acetylglucosamine (GlcNAc) transferase Gene

Homo sapiens

Also known as OGT1; HRNT1; MRX106; XLID106; HINCUT-1; O-GLCNAC

Gene ID: 8473 | Gene type: protein coding

About OGT

Cytogenetic location: Xq13.1 Genomic coordinates (GRCh38): X:71,533,104-71,575,892 (from NCBI)

This gene has 21 transcripts (splice variants), 263 orthologues, 14 paralogues and is associated with 3 phenotypes. Ubiquitous expression in lymph node (RPKM 56.6), spleen (RPKM 53.1) and 25 other tissues.

Summary

This gene encodes a glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains multiple tetratricopeptide repeats that are required for optimal recognition of substrates. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

OGT Products(2)

mRNA	Protein	Name
NM_181672.3	NP_858058.1	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 1
NM_181673.3	NP_858059.1	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 2

OGT Protein Structure

TPR_11

TPR_1

TPR_11

Glyco_transf_41

0
200
400
600
800
1046 a.a.

Protein Preferred Names

Protein Names

UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

O-GlcNAc transferase p110 subunit

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder, X-Linked 106

XLID106	Mrx106
Mental Retardation, X-Linked 106	Mental Retardation, X-Linked, Type 106

Myoepithelioma

Benign Myoepithelioma	Myoepithelial Adenoma
Myoepithelial Neoplasm	Malignant Myoepithelioma

Bainbridge-Ropers Syndrome

BRPS	Severe Feeding Difficulties-Failure To Thrive-Microcephaly Due To Asxl3 Deficiency Syndrome
Asxl3-Related Disorder

Adams-Oliver Syndrome

Adams Oliver Syndrome	Aos
Congenital Scalp Defects With Distal Limb Reduction Anomalies	Aplasia Cutis Congenita With Terminal Transverse Limb Defects
Congenital Scalp Defects With Distal Limb Anomalies	Limb, Scalp And Skull Defects
Limb Scalp And Skull Defects	Absence Defect Of Limbs, Scalp, And Skull

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-17020A	Miglustat hydrochloride	Inhibitor	98.20%	Yes
HY-17020	Miglustat	Inhibitor	≥98.0%	Yes

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-119738	OSMI-1	Inhibitor	99.90%	Unkown
HY-114361	OSMI-4	Inhibitor	99.90%	Unkown
HY-112174	UDP-GlcNAc disodium		≥99.0%	Unkown
HY-100898	OGT 2115	Inhibitor	99.62%	Unkown
HY-136282	OGT-IN-2	Inhibitor	98.73%	Unkown
HY-129411	Sinbaglustat		98.60%	Unkown
HY-145934A	UDP-GlcNAz disodium		98.03%	Unkown
HY-135784	OSMI-2	Inhibitor	98.73%	Unkown
HY-148113	PG 34	Inhibitor	≥98.0%	Unkown
HY-119738A	(Rac)-OSMI-1	Inhibitor	96.05%	Unkown
HY-110363	Miglustat-d9 hydrochloride		/	Unkown
HY-135785	OSMI-3	Inhibitor	/	Unkown
HY-17020S	Miglustat-d9		/	Unkown
HY-RS09765	OGT Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	OGT	MGD	MGI:1339639
Rattus norvegicus	OGT	RGD	RGD:62060

Name
Email *

	Sorry, but the email address you supplied was invalid.