URI1 - URI1 prefoldin like chaperone Gene

Homo sapiens

Also known as RMP; URI; NNX3; C19orf2; PPP1R19

Gene ID: 8725 | Gene type: protein coding

About URI1

Cytogenetic location: 19q12 Genomic coordinates (GRCh38): 19:29,923,657-30,016,612 (from NCBI)

This gene has 13 transcripts (splice variants) and 213 orthologues. Ubiquitous expression in thyroid (RPKM 23.9), testis (RPKM 18.7) and 25 other tissues.

Summary

This gene encodes member of the prefoldin family of molecular chaperones. The encoded protein functions as a scaffolding protein and plays roles in ubiquitination and transcription, in part though interactions with the RNA polymerase II subunit RPB5. This gene may play a role in multiple malignancies including ovarian Cancer and hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 22. [provided by RefSeq, Nov 2011]

URI1 Products(2)

mRNA	Protein	Name
NM_001252641.2	NP_001239570.1	unconventional prefoldin RPB5 interactor 1 isoform c
NM_003796.3	NP_003787.2	unconventional prefoldin RPB5 interactor 1 isoform a

URI1 Protein Structure

Prefoldin

0
100
200
300
400
459 a.a.

Protein Preferred Names

Protein Names

unconventional prefoldin RPB5 interactor 1

RNA polymerase II subunit 5-mediating protein

Related Diseases

Diseases

Alias

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Hypermobility Of Coccyx

Coccygeal Hypermobility Syndrome

Hypermobility Of The Coccyx

Klippel-Feil Syndrome 3

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Neurodegeneration With Brain Iron Accumulation 4

NBIA4	Mpan
Mitochondrial Protein-Associated Neurodegeneration	Nbia Due To C19orf12 Mutation
Neurodegeneration With Brain Iron Accumulation Due To C19orf12 Mutation	Neurodegeneration With Brain Iron Accumulation Type 4
Mitochondrial Membrane Protein Associated Neurodegeneration	Neurodegeneration, With Brain Iron Accumulation, Type 4

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-A0161A	Chlophedianol hydrochloride		99.62%	Unkown
HY-A0161	Chlophedianol		/	Unkown

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-A0161S	Chlophedianol-13C6		/	Unkown
HY-RS15507	URI1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	URI1	VGNC	VGNC:36698
Mus musculus	URI1	MGD	MGI:1342294
Macaca mulatta	URI1	VGNC	VGNC:78918
Canis familiaris	URI1	VGNC	VGNC:48166
Felis catus	URI1	VGNC	VGNC:66853
Rattus norvegicus	URI1	RGD	RGD:1310358

Name
Email *

	Sorry, but the email address you supplied was invalid.