GTF2F1 - general transcription factor IIF subunit 1 Gene

Also Known as BTF4; RAP74; TF2F1; TFIIF

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2962

About GTF2F1

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:6,379,572-6,393,164 (from NCBI)

This gene has 6 transcripts (splice variants) and 211 orthologues. Ubiquitous expression in ovary (RPKM 36.8), testis (RPKM 30.9) and 25 other tissues.

Summary

Enables several functions, including RNA polymerase II general transcription initiation factor activity; Phosphatase activator activity; and promoter-specific chromatin binding activity. Involved in several processes, including positive regulation of transcription by RNA polymerase II; response to virus; and transcription initiation from RNA polymerase II promoter. Located in cell junction and nucleoplasm. Part of transcription factor TFIID complex. [provided by Alliance of Genome Resources, Apr 2022]

GTF2F1 Products (1)

mRNA Protein Name
NM_002096.3 NP_002087.2 general transcription factor IIF subunit 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II general transcription initiation factor activity IDA
IDA: Inferred from direct assay
7929273 GOA
enables RNA polymerase II general transcription initiation factor binding IPI
IPI: Inferred from physical interaction
8625415 GOA
enables phosphatase activator activity IDA
IDA: Inferred from direct assay
12721286 GOA
enables promoter-specific chromatin binding IDA
IDA: Inferred from direct assay
24441171 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
7590250 GOA
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
15723517 GOA
enables protein phosphatase binding IPI
IPI: Inferred from physical interaction
12732728 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of protein binding IMP
IMP: Inferred from mutant phenotype
8662660 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15351637 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
8662660 GOA
involved in response to virus IEP
IEP: Inferred from expression pattern
16548883 GOA
involved in transcription elongation by RNA polymerase II IDA
IDA: Inferred from direct assay
15351637 GOA
involved in transcription initiation at RNA polymerase II promoter IDA
IDA: Inferred from direct assay
7929273 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IMP
IMP: Inferred from mutant phenotype
15723517 GOA
part of protein-containing complex IMP
IMP: Inferred from mutant phenotype
12732728 GOA
part of transcription factor TFIID complex IDA
IDA: Inferred from direct assay
27193682 GOA
part of transcription factor TFIIF complex IPI
IPI: Inferred from physical interaction
11183778 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GTF2F1 Protein Structure

TFIIF_alpha

TFIIF_alpha: Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) (3 - 517)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 517 a.a.
Protein Preferred Names Protein Names

general transcription factor IIF subunit 1

  • TFIIF-alpha

GTF2F1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GTF2F1 P35269 GTF2F2 Homo sapiens P13984
TAP
24981860
Intra
GTF2F1 P35269 GTF2F2 Homo sapiens P13984
Complementation
31467278
Intra
GTF2F1 P35269 GTF2F2 Homo sapiens P13984
BRET
37398436
Intra
GTF2F1 P35269 GTF2F2 Homo sapiens P13984
Lumier
37398436
Intra
GTF2F1 P35269 GTF2F2 Homo sapiens P13984
MAPPIT
31467278
Intra
GTF2F1 P35269 GTF2F2 Homo sapiens P13984
Y2H
7854423
Intra
GTF2F1 P35269 GTF2F2 Homo sapiens P13984
SLC
31467278
Intra
GTF2F1 P35269 GTF2F2 Homo sapiens P13984
X-Ray Diffraction
11183778
Intra
GTF2F1 P35269 CTDP1 Homo sapiens Q9Y5B0
NMR
12732728
Intra
GTF2F1 P35269 URI1 Homo sapiens O94763
Far-WB
12737519
Intra
GTF2F1 P35269 URI1 Homo sapiens O94763
Anti Tag CoIP
12737519
Intra
GTF2F1 P35269 TAF1 Homo sapiens P21675
Anti Tag CoIP
7590250
Intra
GTF2F1 P35269 TAF1 Homo sapiens P21675
CoIP
7590250
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05896 GTF2F1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus GTF2F1 RGD RGD:1359646
Bos taurus GTF2F1 VGNC VGNC:97277
Canis familiaris GTF2F1 VGNC VGNC:41546
Macaca mulatta GTF2F1 VGNC VGNC:73309
Felis catus GTF2F1 VGNC VGNC:67497
Mus musculus GTF2F1 MGD MGI:1923848
Others GTF2F1 NCBI