GTF2F2 - general transcription factor IIF subunit 2 Gene

Also Known as BTF4; RAP30; TF2F2; TFIIF

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2963

About GTF2F2

Cytogenetic location: 13q14.12-q14.13 Genomic coordinates (GRCh38): 13:45,120,510-45,284,893 (from NCBI)

This gene has 3 transcripts (splice variants) and 289 orthologues. Ubiquitous expression in skin (RPKM 5.5), adrenal (RPKM 5.1) and 25 other tissues.

Summary

Predicted to enable RNA polymerase II general transcription initiation factor activity. Involved in transcription by RNA polymerase II. Located in microtubule Cytoskeleton and nucleoplasm. Part of transcription preinitiation complex. [provided by Alliance of Genome Resources, Apr 2022]

GTF2F2 Products (1)

mRNA Protein Name
NM_004128.3 NP_004119.1 general transcription factor IIF subunit 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
7854423 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15351637 GOA
involved in transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
8662660 GOA
involved in transcription elongation by RNA polymerase II IDA
IDA: Inferred from direct assay
15351637 GOA
involved in transcription initiation at RNA polymerase II promoter IDA
IDA: Inferred from direct assay
15351637 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
9841876 GOA
part of transcription factor TFIIF complex IPI
IPI: Inferred from physical interaction
11183778 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GTF2F2 Protein Structure

TFIIF_beta

TFIIF_beta: Transcription initiation factor IIF, beta subunit (5 - 102)

TFIIF_beta

TFIIF_beta: Transcription initiation factor IIF, beta subunit (99 - 241)

  • 0
  • 100
  • 200
  • 249 a.a.
Protein Preferred Names Protein Names

general transcription factor IIF subunit 2

  • ATP-dependent helicase GTF2F2

GTF2F2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GTF2F2 P13984 DYNLT2B Homo sapiens Q8WW35
Display Tech
20195357
Intra
GTF2F2 P13984 RPL27A Homo sapiens P46776
Display Tech
20195357
Intra
GTF2F2 P13984 URI1 Homo sapiens O94763
Display Tech
20195357
Intra
GTF2F2 P13984 URI1 Homo sapiens O94763
Anti Tag CoIP
12737519
Intra
GTF2F2 P13984 URI1 Homo sapiens O94763
Far-WB
12737519
Intra
GTF2F2 P13984 GTF2F1 Homo sapiens P35269
Lumier
37398436
Intra
GTF2F2 P13984 GTF2F1 Homo sapiens P35269
BRET
37398436
Intra
GTF2F2 P13984 FHL2 Homo sapiens Q14192
Validated Y2H
32296183
Intra
GTF2F2 P13984 MAPRE3 Homo sapiens Q9UPY8
Validated Y2H
32296183
Intra
GTF2F2 P13984 ZMYND19 Homo sapiens Q96E35
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

GTF2F2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P86891 GTF2F2 Antibody (YA6584) WB, IHC-P Human, Rat

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05897 GTF2F2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus GTF2F2 VGNC VGNC:97452
Rattus norvegicus GTF2F2 RGD RGD:620772
Mus musculus GTF2F2 MGD MGI:1915955
Macaca mulatta GTF2F2 VGNC VGNC:73310
Bos taurus GTF2F2 VGNC VGNC:53815
Others GTF2F2 NCBI