RPAP3 - RNA polymerase II associated protein 3 Gene

Also Known as Tah1; hSpagh

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 79657

About RPAP3

Cytogenetic location: 12q13.11 Genomic coordinates (GRCh38): 12:47,661,249-47,706,030 (from NCBI)

This gene has 7 transcripts (splice variants), 211 orthologues and 18 paralogues. Ubiquitous expression in lymph node (RPKM 11.2), appendix (RPKM 8.8) and 25 other tissues.

Summary

This gene encodes an RNA polymerase II-associated protein. The encoded protein may function in transcriptional regulation and may also regulate Apoptosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]

RPAP3 Products (3)

mRNA	Protein	Name
NM_001146075.2	NP_001139547.1	RNA polymerase II-associated protein 3 isoform 2
NM_001146076.2	NP_001139548.1	RNA polymerase II-associated protein 3 isoform 3
NM_024604.3	NP_078880.2	RNA polymerase II-associated protein 3 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18538670	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of R2TP complex	IDA IDA: Inferred from direct assay	26711270	GOA
part of R2TP complex	IPI IPI: Inferred from physical interaction	29662061	GOA
part of RPAP3/R2TP/prefoldin-like complex	IPI IPI: Inferred from physical interaction	31738558	GOA
part of protein folding chaperone complex	IPI IPI: Inferred from physical interaction	29844425	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPAP3 Protein Structure

TPR_11

TPR_1

TPR_11

TPR_1

RPAP3_C

0
200
400
600
665 a.a.

Protein Preferred Names	Protein Names
RNA polymerase II-associated protein 3

RPAP3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RPAP3	Q9H6T3	DNAAF10	Homo sapiens	Q96MX6	Anti Tag CoIP	33961781
Intra	RPAP3	Q9H6T3	DNAAF10	Homo sapiens	Q96MX6	Anti Tag CoIP	25036637
Intra	RPAP3	Q9H6T3	DNAAF10	Homo sapiens	Q96MX6	Pull Down	18538670
Intra	RPAP3	Q9H6T3	POLR3A	Homo sapiens	O14802	Anti Tag CoIP	33961781
Intra	RPAP3	Q9H6T3	POLR3A	Homo sapiens	O14802	Lumier	25036637
Intra	RPAP3	Q9H6T3	HSP90AA1	Homo sapiens	P07900	ITC	24794838
Intra	RPAP3	Q9H6T3	HSP90AA1	Homo sapiens	P07900	X-Ray Diffraction	24794838
Intra	RPAP3	Q9H6T3	HSP90AB1	Homo sapiens	P08238	Pull Down	24794838
Intra	RPAP3	Q9H6T3	URI1	Homo sapiens	O94763	Anti Tag CoIP	33961781
Intra	RPAP3	Q9H6T3	URI1	Homo sapiens	O94763	Anti Tag CoIP	25036637
Intra	RPAP3	Q9H6T3	UXT	Homo sapiens	Q9UBK9	Anti Tag CoIP	33961781
Intra	RPAP3	Q9H6T3	UXT	Homo sapiens	Q9UBK9	Anti Tag CoIP	25036637
Intra	RPAP3	Q9H6T3	PFDN2	Homo sapiens	Q9UHV9	Anti Tag CoIP	33961781
Intra	RPAP3	Q9H6T3	PFDN2	Homo sapiens	Q9UHV9	Anti Tag CoIP	25036637
Intra	RPAP3	Q9H6T3	TERF1	Homo sapiens	P54274	Pull Down	21044950
Intra	RPAP3	Q9H6T3	TERF1	Homo sapiens	P54274	BiFC	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Primary Ciliary Dyskinesia	Immotile Cilia Syndrome Kartagener Syndrome Dextrocardia Bronchiectasis And Sinusitis Pcd Ciliary Motility Disorders Ciliary Motility Disorder Immotile Ciliary Syndrome Ciliary Dyskinesia Primary Ics Polynesian Bronchiectasis Dextrocardia-Bronchiectasis-Sinusitis Syndrome Immotile Cilia Syndrome, Kartagener Type Primary Ciliary Dyskinesia And Situs Inversus Primary Ciliary Dyskinesia, Kartagener Type Siewert Syndrome Dyskinesia, Ciliary, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12149	RPAP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RPAP3	VGNC	VGNC:34100
Felis catus	RPAP3	VGNC	VGNC:64730
Rattus norvegicus	RPAP3	RGD	RGD:1303036
Macaca mulatta	RPAP3	VGNC	VGNC:76834
Canis familiaris	RPAP3	VGNC	VGNC:45707
Mus musculus	RPAP3	MGD	MGI:1277218
Others	RPAP3	NCBI