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  4. Chlophedianol hydrochloride

Chlophedianol hydrochloride  (Synonyms: Clofedanol hydrochloride; Calmotusin hydrochloride; NSC 113595 hydrochloride)

Cat. No.: HY-A0161A Purity: 99.62%
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Chlophedianol (Clofedanol) hydrochloride is an orally active and potent antitussive agent. Chlophedianol hydrochloride can be used for the research of acute cough due to upper respiratory tract infections (URIs).

For research use only. We do not sell to patients.

Chlophedianol hydrochloride Chemical Structure

Chlophedianol hydrochloride Chemical Structure

CAS No. : 511-13-7

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5 mg USD 225 In-stock
10 mg USD 360 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Chlophedianol hydrochloride:

Chlophedianol hydrochloride Related Antibodies

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Description

Chlophedianol (Clofedanol) hydrochloride is an orally active and potent antitussive agent. Chlophedianol hydrochloride can be used for the research of acute cough due to upper respiratory tract infections (URIs)[1][2].

In Vivo

Chlophedianol (Clofedanol) hydrochloride (0-162 mg/kg; p.o. or s.c.; once) lowers the volume output of respiratory tract fluid in rabbits and cats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Healthy, adult, male rabbits and cats[1]
Dosage: 2.0, 6.0, 18, 54 and 162 mg/kg (PO) or 1.0, 3.0, 9.0, 27 and 81 mg/kg (SC)
Administration: Oral or subcutaneous administration, once
Result: Lowered the volume output of respiratory tract fluid, slightly but significantly over a period of one to three hours after administration. Produced a decrease in the number of animals in which pledgets of mucus appeared in the respiratory tract.
Molecular Weight

326.26

Formula

C17H21Cl2NO
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

ClC1=C(C(C2=CC=CC=C2)(CCN(C)C)O)C=CC=C1.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (383.13 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0650 mL 15.3252 mL 30.6504 mL
5 mM 0.6130 mL 3.0650 mL 6.1301 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0650 mL 15.3252 mL 30.6504 mL 76.6260 mL
5 mM 0.6130 mL 3.0650 mL 6.1301 mL 15.3252 mL
10 mM 0.3065 mL 1.5325 mL 3.0650 mL 7.6626 mL
15 mM 0.2043 mL 1.0217 mL 2.0434 mL 5.1084 mL
20 mM 0.1533 mL 0.7663 mL 1.5325 mL 3.8313 mL
25 mM 0.1226 mL 0.6130 mL 1.2260 mL 3.0650 mL
30 mM 0.1022 mL 0.5108 mL 1.0217 mL 2.5542 mL
40 mM 0.0766 mL 0.3831 mL 0.7663 mL 1.9157 mL
50 mM 0.0613 mL 0.3065 mL 0.6130 mL 1.5325 mL
60 mM 0.0511 mL 0.2554 mL 0.5108 mL 1.2771 mL
80 mM 0.0383 mL 0.1916 mL 0.3831 mL 0.9578 mL
100 mM 0.0307 mL 0.1533 mL 0.3065 mL 0.7663 mL
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Chlophedianol hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chlophedianol511-13-7ClofedanolCalmotusinNSC 113595NSC113595NSC-113595Otherscoughantitussiveupper respiratory tract infectionsorally activeInhibitorinhibitorinhibit

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