TRAK1 - trafficking kinesin protein 1 Gene

Also Known as DEE68; MILT1; EIEE68; OIP106

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 22906

About TRAK1

Cytogenetic location: 3p22.1 Genomic coordinates (GRCh38): 3:42,013,093-42,225,890 (from NCBI)

This gene has 12 transcripts (splice variants), 216 orthologues, 2 paralogues and is associated with 2 phenotypes. Ubiquitous expression in heart (RPKM 17.5), stomach (RPKM 12.1) and 24 other tissues.

Summary

Predicted to enable GABA Receptor binding activity and Myosin binding activity. Involved in endosome to lysosome transport. Located in early endosome and mitochondrion. Implicated in developmental and epileptic encephalopathy 68. [provided by Alliance of Genome Resources, Apr 2022]

TRAK1 Products (11)

mRNA	Protein	Name
NM_001042646.3	NP_001036111.1	trafficking kinesin-binding protein 1 isoform 1
NM_001265608.2	NP_001252537.1	trafficking kinesin-binding protein 1 isoform 3
NM_001265609.2	NP_001252538.1	trafficking kinesin-binding protein 1 isoform 4
NM_001265610.1	NP_001252539.1	trafficking kinesin-binding protein 1 isoform 5
NM_001349245.1	NP_001336174.1	trafficking kinesin-binding protein 1 isoform 6
NM_001349246.2	NP_001336175.1	trafficking kinesin-binding protein 1 isoform 7
NM_001349247.2	NP_001336176.1	trafficking kinesin-binding protein 1 isoform 8
NM_001349248.1	NP_001336177.1	trafficking kinesin-binding protein 1 isoform 9
NM_001349249.1	NP_001336178.1	trafficking kinesin-binding protein 1 isoform 10
NM_001410741.1	NP_001397670.1	trafficking kinesin-binding protein 1 isoform 11
NM_014965.5	NP_055780.2	trafficking kinesin-binding protein 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15644324	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in endosome to lysosome transport	IDA IDA: Inferred from direct assay	18675823	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19528298	GOA
located in early endosome	IDA IDA: Inferred from direct assay	18675823	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	15644324	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRAK1 Protein Structure

HAP1_N

Milton

0
200
400
600
800
953 a.a.

Protein Preferred Names	Protein Names
trafficking kinesin-binding protein 1	106 kDa O-GlcNAc transferase-interacting protein

TRAK1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TRAK1	Q9UPV9	RHOT1	Homo sapiens	Q8IXI2	Anti Bait CoIP	19135897
Intra	TRAK1	Q9UPV9	RHOT1	Homo sapiens	Q8IXI2	Anti Tag CoIP	33961781
Intra	TRAK1	Q9UPV9	RHOT1	Homo sapiens	Q8IXI2	Anti Bait CoIP	24995978
Intra	TRAK1	Q9UPV9	RHOT2	Homo sapiens	Q8IXI1	Anti Tag CoIP	33961781
Intra	TRAK1	Q9UPV9	RHOT2	Homo sapiens	Q8IXI1	Anti Tag CoIP	16630562
Intra	TRAK1	Q9UPV9	OGT	Homo sapiens	O15294	Anti Tag CoIP	24995978
Intra	TRAK1	Q9UPV9	KIF5A	Homo sapiens	Q12840	Anti Tag CoIP	33961781
Intra	TRAK1	Q9UPV9	KIF5A	Homo sapiens	Q12840	Anti Tag CoIP	24161670
Cross	TRAK1	Q9UPV9	Ogt	Rattus norvegicus	P56558	Anti Tag CoIP	24995978
Cross	TRAK1	Q9UPV9	Ogt	Rattus norvegicus	P56558	Anti Bait CoIP	24995978
Cross	TRAK1	Q9UPV9	Ogt	Rattus norvegicus	P56558	IF	24995978
Cross	TRAK1	Q9UPV9	Ogt	Rattus norvegicus	P56558	Confocal	24995978

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Developmental And Epileptic Encephalopathy 68	DEE68 Epileptic Encephalopathy, Early Infantile, 68 Eiee68 Developmental And Epileptic Encephalopathy, 68 Early Infantile Epileptic Encephalopathy 68
Non-Specific Early-Onset Epileptic Encephalopathy	Undetermined Early-Onset Epileptic Encephalopathy Non-Specific Eoee Undetermined Eoee
Status Epilepticus	Grand Mal Status Epilepticus Grand Mal Status Gcse Generalized Convulsive Status Epilepticus Se Epilepsy With Status Epilepticus
Encephalopathy	Brain Diseases Encephalopathies Toxic Encephalopathy Toxic Brain Fever Toxic Brain Inflammation Toxic Brain Stem Inflammation Toxic Cerebral Fever Toxic Cerebrospinal Fever Toxic Cerebrospinal Inflammation Encephalopathy Nec Encephalopathy Nos Encephalopathy Disease Encephalopathy Syndrome
Hyperekplexia	Hereditary Hyperekplexia Kok Disease Congenital Stiff Man Syndrome Familial Startle Disease Sthe Stiff-Baby Syndrome Hereditary Hyperexplexia Startle Disease Exaggerated Startle Reaction Hyperexplexia Hereditary Startle Disease, Familial Startle Reaction, Exaggerated Stiff-Man Syndrome, Congenital Stiff-Person Syndrome, Congenital Congenital Stiff-Man Syndrome Congenital Stiff-Person Syndrome Familial Hyperekplexia Startle Syndrome Stiff Baby Syndrome Hyperekplexia, Hereditary Stiff-Person Syndrome
Developmental And Epileptic Encephalopathy	Encephalopathy, Developmental And Epileptic
Hypertonia
Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive	Charcot-Marie-Tooth Disease Type 4 Charcot-Marie-Tooth Disease Type 4e Hereditary Motor And Sensory Neuropathy Cmt4e CHN1 Hypomyelinating Neuropathy, Congenital, 1 Charcot-Marie-Tooth Neuropathy Type 4e Neuropathy, Congenital Hypomyelinating, 1 Ar-Cmt1 Autosomal Recessive Demyelinating Charcot-Marie-Tooth Cmt4 Neuropathy, Congenital Hypomyelinating Or Amyelinating, Autosomal Recessive Hypomyelination, Severe Congenital Charcot-Marie-Tooth Disease, Type 4e Charcot-Marie-Tooth Neuropathy, Type 4e Autosomal Recessive Congenital Hypomyelinating Or Amyelinating Neuropathy Autosomal Recessive Congenital Hypomyelinating Neuropathy Congenital Amyelinating Neuropathy Congenital Hypomyelinating Neuropathy Autosomal Recessive Neuropathy, Congenital Hypomyelinating Or Amyelinating Severe Congenital Hypomyelination Hereditary Sensory Motor Neuropathy Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive Neuropathy, Hypomyelinating, Congenital, Type 1 Neuropathy, Motor And Sensory, Hereditary Congenital Hypomyelinating Neuropathy Hereditary Motor And Sensory Neuropathies Hereditary Sensorimotor Neuropathy Hmsn - [Hereditary Motor And Sensory Neuropathy] Hsmn - [Hereditary Sensory And Motor Neuropathy] Hereditary Motor And Sensory Neuropathy, Types I-Iv
Hereditary Spastic Paraplegia	Familial Spastic Paraplegia Hereditary Spastic Paraparesis Strumpell-Lorrain Disease Familial Spastic Paraparesis Hsp Spg Strümpell-Lorrain Disease Spastic Paraplegia, Hereditary French Settlement Disease Strumpell-Lorrain Syndrome Fsp Spastic Paraplegia, Familial Spastic Paraplegia Hereditary Spastic Paraplegia 3, Autosomal Dominant Spastic Paraparesis Hereditary Spastic Paralysis Familial Spastic Paralysis Hereditary Spastic Ataxia
Early Infantile Epileptic Encephalopathy	Early Infantile Epileptic Encephalopathy With Burst-Suppression Early Infantile Epileptic Encephalopathy With Suppression Bursts Eiee Early Infantile Epileptic Encephalopathy With Suppression-Bursts Ohtahara Syndrome Encephalopathy, Epileptic, Early Infantile
Charcot-Marie-Tooth Disease	Cmt Hmsn Hereditary Motor And Sensory Neuropathy Pma Cmt - Charcot-Marie-Tooth Disease Charcot Marie Tooth Disease Charcot-Marie-Tooth Hereditary Neuropathy Charcot-Marie-Tooth Syndrome Peroneal Muscular Atrophy Hereditary Motor And Sensory Neuropathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14979	TRAK1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22874	Trak1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TRAK1	MGD	MGI:1914345
Bos taurus	TRAK1	VGNC	VGNC:97320
Macaca mulatta	TRAK1	VGNC	VGNC:79830
Rattus norvegicus	TRAK1	RGD	RGD:1307844
Felis catus	TRAK1	VGNC	VGNC:66505
Canis familiaris	TRAK1	VGNC	VGNC:47773
Others	TRAK1	NCBI