Ogt - O-linked N-acetylglucosamine (GlcNAc) transferase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 26295

Summary

Enables several functions, including identical protein binding activity; monosaccharide binding activity; and protein N-acetylglucosaminyltransferase activity. Involved in several processes, including intracellular distribution of mitochondria; negative regulation of protein targeting to membrane; and regulation of protein phosphorylation. Located in several cellular components, including euchromatin; neuronal cell body; and zymogen granule. Part of protein N-acetylglucosaminyltransferase complex. Biomarker of congestive heart failure. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 106. Orthologous to human OGT (O-linked N-acetylglucosamine (GlcNAc) transferase). [provided by Alliance of Genome Resources, Apr 2022]

Ogt Products (2)

mRNA Protein Name
NM_001398715.1 NP_001385644.1 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 2
NM_017107.3 NP_058803.2 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
10542233 RGD
enables peptide binding IDA
IDA: Inferred from direct assay
10542233 RGD
enables protein O-acetylglucosaminyltransferase activity IDA
IDA: Inferred from direct assay
9083067 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12435728 RGD
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
24995978 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
1533623 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
21712532 RGD
involved in cellular response to insulin stimulus IEP
IEP: Inferred from expression pattern
15561949 RGD
involved in cellular response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
19098112 RGD
involved in cellular response to toxic substance IEP
IEP: Inferred from expression pattern
12054585 RGD
involved in forebrain development IEP
IEP: Inferred from expression pattern
22928023 RGD
involved in glucosamine metabolic process IDA
IDA: Inferred from direct assay
12054585 RGD
involved in glucosamine metabolic process IMP
IMP: Inferred from mutant phenotype
18539296 RGD
involved in intracellular distribution of mitochondria IMP
IMP: Inferred from mutant phenotype
24995978 RGD
involved in negative regulation of cellular response to hypoxia IMP
IMP: Inferred from mutant phenotype
18539296 RGD
involved in negative regulation of peptidyl-serine phosphorylation IMP
IMP: Inferred from mutant phenotype
21712532 RGD
involved in negative regulation of peptidyl-threonine phosphorylation IMP
IMP: Inferred from mutant phenotype
21712532 RGD
involved in negative regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
21712532 RGD
involved in negative regulation of protein targeting to membrane IMP
IMP: Inferred from mutant phenotype
21712532 RGD
involved in positive regulation of cell size IMP
IMP: Inferred from mutant phenotype
23665912 RGD
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
20978008 RGD
involved in positive regulation of protein localization to nucleus IMP
IMP: Inferred from mutant phenotype
16052526 RGD
involved in positive regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
20978008 RGD
involved in positive regulation of reactive oxygen species biosynthetic process IMP
IMP: Inferred from mutant phenotype
21712532 RGD
involved in protein O-linked glycosylation IDA
IDA: Inferred from direct assay
9083067 RGD
involved in protein O-linked glycosylation IMP
IMP: Inferred from mutant phenotype
24995978 RGD
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
12618343 RGD
is active in cerebellar granule cell to Purkinje cell synapse IDA
IDA: Inferred from direct assay
12618343 RGD
located in euchromatin IDA
IDA: Inferred from direct assay
10580430 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
12618343 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
22928023 RGD
is active in postsynaptic cytosol IDA
IDA: Inferred from direct assay
12618343 RGD
is active in presynaptic cytosol IDA
IDA: Inferred from direct assay
12618343 RGD
part of protein N-acetylglucosaminyltransferase complex IDA
IDA: Inferred from direct assay
10542233 RGD
located in zymogen granule IDA
IDA: Inferred from direct assay
10580430 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

  • O linked N-acetylglucosamine transferase

  • O-GlcNAc transferase subunit p110

  • O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)

  • O-linked N-acetylglucosamine transferase 110 kDa subunit

Ogt Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Ogt P56558 Nrf1 Mus musculus Q9WU00
Anti Tag CoIP
26231763
Cross
Ogt P56558 Foxo4 Mus musculus Q9WVH3
Anti Tag CoIP
19932102
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (18)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-119738 OSMI-1 Inhibitor 99.88% Unkown
HY-145934 UDP-GalNAz disodium Substrate 99.89% Unkown
HY-114361 OSMI-4 Inhibitor 99.69% Unkown
HY-112174 UDP-GlcNAc disodium 99.92% Unkown
HY-145934A UDP-GlcNAz disodium Substrate 99.74% Unkown
HY-136282 ST045849 Inhibitor 99.96% Unkown
HY-N3677 Dammarenediol II Inhibitor 99.81% Unkown
HY-101548 OGT-IN-1 Inhibitor 98.14% Unkown
HY-139793 UDP-glucosamine disodium 99.44% Unkown
HY-135784 OSMI-2 Inhibitor 99.59% Unkown
HY-W039939 2-Azido-2-deoxy-D-glucose, 98% Substrate 98.0% Unkown
HY-119738A (Rac)-OSMI-1 Inhibitor 96.51% Unkown
HY-148113 PG 34 98.0% Unkown
HY-125278 OGT-IN-4 Inhibitor 99.65% Unkown
HY-145934B UDP-GlcNAz Substrate / Unkown
HY-135785 OSMI-3 Inhibitor 99.08% Unkown
HY-149552 Ac4-5SGlcNAc Inhibitor / Unkown
HY-W477597 BZX2 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ogt NCBI NCBI:8473