UDP-GlcNAz disodium
Based on 1 Customer Validation
UDP-GlcNAz disodium is the analogue of UDP-GlcNAc disodium (HY-112174). UDP-GlcNAc disodium is the donor substrate of many N-acetylgalactosaminyltransferases, enzymes which transfer GlcNAc from the nucleotide sugar to a saccharide or peptide acceptor. UDP-GlcNAc disodium is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
For research use only. We do not sell to patients.
- Purity: 99.74%
- CAS No.: 1611490-64-2
- Formula: C17H24N6Na2O17P2
- Molecular Weight:692.33
-
Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
UDP-GlcNAz disodium is a sugar donor. UDP-GlcNAz disodium serves as a substrate for OGTase and O-GlcNAcase. UDP-GlcNAz disodium can glycosylate p62 and its glycosidic bond can be cleaved by O-GlcNAcase through catalysis. UDP-GlcNAz disodium can be used in the research of related protein glycosylation[1][2].
UDP-GlcNAz disodium (3 days) can be incorporated into nuclear proteins in Jurkat cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 1611490-64-2
-
Appearance Solid
-
Molecular Weight 692.33
-
Formula C17H24N6Na2O17P2
-
Color White to off-white
-
SMILES
O=C(C=CN1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(OP(O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3NC(CN=[N+]=[N-])=O)(O[Na])=O)(O[Na])=O)O2)NC1=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
H2O : 125 mg/mL (180.55 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (276 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
[1]. Vocadlo DJ, et, al. A chemical approach for identifying O-GlcNAc-modified proteins in cells. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9116-21. [Content Brief]
[2]. Kim EJ, et al. Versatile O-GlcNAc transferase assay for high-throughput identification of enzyme variants, substrates, and inhibitors. Bioconjug Chem. 2014 Jun 18;25(6):1025-30. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.4444 mL | 7.2220 mL | 14.4440 mL | 36.1099 mL |
| 5 mM | 0.2889 mL | 1.4444 mL | 2.8888 mL | 7.2220 mL | |
| 10 mM | 0.1444 mL | 0.7222 mL | 1.4444 mL | 3.6110 mL | |
| 15 mM | 0.0963 mL | 0.4815 mL | 0.9629 mL | 2.4073 mL | |
| 20 mM | 0.0722 mL | 0.3611 mL | 0.7222 mL | 1.8055 mL | |
| 25 mM | 0.0578 mL | 0.2889 mL | 0.5778 mL | 1.4444 mL | |
| 30 mM | 0.0481 mL | 0.2407 mL | 0.4815 mL | 1.2037 mL | |
| 40 mM | 0.0361 mL | 0.1805 mL | 0.3611 mL | 0.9027 mL | |
| 50 mM | 0.0289 mL | 0.1444 mL | 0.2889 mL | 0.7222 mL | |
| 60 mM | 0.0241 mL | 0.1204 mL | 0.2407 mL | 0.6018 mL | |
| 80 mM | 0.0181 mL | 0.0903 mL | 0.1805 mL | 0.4514 mL | |
| 100 mM | 0.0144 mL | 0.0722 mL | 0.1444 mL | 0.3611 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
UDP-GlcNAz disodium Related Classifications
HY-145934A Related Classifications
Powered by Bioz