Referencia número: HY-112174

UDP-GlcNAc disodium

(Synonyms: UDP-α-D-N-Acetylglucosamine disodium)

8 Cited Publications

Revisión del cliente

Based on 8 publication(s) in Google Scholar

UDP-GlcNAc Disodium Salt (UDP-α-D-N-Acetylglucosamine Disodium Salt) is a donor substrate of O-GlcNAc transferase (OGT).

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Pureza: 99.92%
No. CAS: 91183-98-1
Fòrmula: C₁₇H₂₅N₃Na₂O₁₇P₂
Peso molecular:651.32

Almacenamiento:

-20°C, sealed storage, away from moisture

* The compound is unstable in solutions, freshly prepared is recommended.

UDP-GlcNAc disodium Chemical Structure

No. CAS: 91183-98-1

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Actividad biológica
- Descripciòn
- In Vitro
Chemical Information
Publications (8)
Solvente y solubilidad
- In Vitro
Pureza y Documentación
Referencias
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

UDP-GlcNAc Disodium Salt (UDP-α-D-N-Acetylglucosamine Disodium Salt) is a donor substrate of O-GlcNAc transferase (OGT).

In Vitro

OGT is a nucleocytoplasmic glycosyltransferase (uridine diphospho-N--acetylglucosamine:polypeptide β-N-acetylglucosaminyltransferase or O-GlcNAc transferase) assigned to the GT41 family in the CAZY (Carbohydrate-Active enZYme) database. Using UDP-GlcNAc Disodium Salt (UDP-GlcNAc) as the donor substrate, this enzyme modifies thousands of proteins by adding a unique N-acetylglucosamine residue onto acceptor substrates mainly confined within cytosol and nucleus^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 91183-98-1
Appearance Solid
Peso molecular 651.32
Fòrmula C₁₇H₂₅N₃Na₂O₁₇P₂
Color White to off-white
SMILES

O[C@H]1[C@H](N2C(NC(C=C2)=O)=O)O[C@H](COP(OP(O[C@@H]3[C@@H]([C@H]([C@H](O)[C@@H](CO)O3)O)NC(C)=O)(O[Na])=O)(O[Na])=O)[C@H]1O
Synonyms

UDP-α-D-N-Acetylglucosamine disodium
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

-20°C, sealed storage, away from moisture

* The compound is unstable in solutions, freshly prepared is recommended.

Publications (8)

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Signal Transduct Target Ther

O-GlcNAcylation of YTHDF2 promotes HBV-related hepatocellular carcinoma progression in an N6-methyladenosine-dependent manner. [Abstract]

2023 Feb 10;8(1):63. PMID: 36765030
Cancer Res

MTHFD2 Enhances cMYC O-GlcNAcylation to Promote Sunitinib Resistance in Renal Cell Carcinoma. [Abstract]

2025 Mar 14;85(6):1113-1129. PMID: 39804969

UDP-GlcNAc disodium purchased from MedChemExpress. Usage Cited in: Cancer Res. 2025 Mar 14;85(6):1113-1129. [Abstract]

MTHFD2 knockdown cells and control cells were treated with sunitinib (10 μM) and UDP-GlcNAc (10 μM) for 48 hours. Cell viability (n = 3).

UDP-GlcNAc disodium purchased from MedChemExpress. Usage Cited in: Cancer Res. 2025 Mar 14;85(6):1113-1129. [Abstract]

MTHFD2 knockdown cells and control cells were treated with sunitinib (10 μmol/L) and UDP-GlcNAc (10 μmol/L) for 48 hours. Cell apoptosis (n = 3) were used to assess the killing capacity of sunitinib. PI, propidium iodide. G, Relative levels of metabolites in MTHFD2 knockdown cells measured by untargeted metabolomics (n = 6). F6P, fructose-6-phosphate;

UDP-GlcNAc disodium purchased from MedChemExpress. Usage Cited in: Cancer Res. 2025 Mar 14;85(6):1113-1129. [Abstract]

Immunoblotting analysis of whole cell lysate (input) and His pull-down products derived from 786O cells transfected with indicated constructs and treated with MG132 (10 μmol/L) for 6 hours after cells were treated with or without UDP-GlcNAc (10 μM) for 24 hours. NC, negative control. The results showed that UDP-GlcNAc could reverse the increased c-MYC ubiquitination resulting from the silencing of MTHFD2 expression.
Plant Cell

SlSEC1- and SlSPY-mediated O-glycosylation stabilizes the transcription factor SlNOR to promote tomato fruit ripening. [Abstract]

2026 May 14:koag144. PMID: 42135064
Int J Biol Sci

O-GlcNAcylation of ZEB1 facilitated mesenchymal pancreatic cancer cell ferroptosis. [Abstract]

2022 Jun 21;18(10):4135-4150. PMID: 35844792
Dev Cell

A pathological role of O-GlcNAcylation-driven TR11B production and function in lung adenocarcinoma. [Abstract]

2025 Sep 3:S1534-5807(25)00530-1. PMID: 40930100
Mol Med

New perspectives on YTHDF2 O-GlcNAc modification in the pathogenesis of intervertebral disc degeneration. [Abstract]

2024 Oct 18;30(1):180. PMID: 39425013
PLoS Pathog

O-GlcNAcylation licenses RNF166 to degrade the M protein of porcine coronaviruses. [Abstract]

2026 Jun 25;22(6):e1014301. PMID: 42348500
Laurea Magistrale in Biomedical Engineering, Politecnico di Milano

2019 Jun.

Solvente y solubilidad

In Vitro:

H₂O : 125 mg/mL (191.92 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.5353 mL

7.6767 mL

15.3534 mL

5 mM

0.3071 mL

1.5353 mL

3.0707 mL

10 mM

0.1535 mL

0.7677 mL

1.5353 mL

Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (274 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Lefebvre T, et al. Antibodies and activity measurements for the detection of O-GlcNAc transferase and assay of its substrate, UDP-GlcNAc. Methods Mol Biol. 2013;1022:147-59. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	1.5353 mL	7.6767 mL	15.3534 mL	38.3836 mL
	5 mM	0.3071 mL	1.5353 mL	3.0707 mL	7.6767 mL
	10 mM	0.1535 mL	0.7677 mL	1.5353 mL	3.8384 mL
	15 mM	0.1024 mL	0.5118 mL	1.0236 mL	2.5589 mL
	20 mM	0.0768 mL	0.3838 mL	0.7677 mL	1.9192 mL
	25 mM	0.0614 mL	0.3071 mL	0.6141 mL	1.5353 mL
	30 mM	0.0512 mL	0.2559 mL	0.5118 mL	1.2795 mL
	40 mM	0.0384 mL	0.1919 mL	0.3838 mL	0.9596 mL
	50 mM	0.0307 mL	0.1535 mL	0.3071 mL	0.7677 mL
	60 mM	0.0256 mL	0.1279 mL	0.2559 mL	0.6397 mL
	80 mM	0.0192 mL	0.0960 mL	0.1919 mL	0.4798 mL
	100 mM	0.0154 mL	0.0768 mL	0.1535 mL	0.3838 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Bioz

Keywords

UDP-GlcNAc disodium

8 Cited Publications

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Help & FAQs

Complete Stock Solution Preparation Table

Bioz

UDP-GlcNAc disodium

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OSMI-1

GDP-D-mannose disodium

Thiamet G

Uridine 5′-diphosphoglucose disodium

CMP-Sialic acid sodium salt

ATP

UDP-glucuronic acid trisodium

UDP-GalNAz disodium

GDP-L-fucose

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Publications Citing Use of MedChemExpress (MCE) UDP-GlcNAc disodium

Actividad biológica

Chemical Information

Publications (8)

Solvente y solubilidad

Pureza y Documentación

Referencias

Help & FAQs

Complete Stock Solution Preparation Table

UDP-GlcNAc disodium Related Classifications

HY-112174 Related Classifications

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