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UDP-GlcNAc

(Synonyms: UDP-N-Acetyl-D-glucosamine; Uridine diphospho-N-acetylglucosamine; UDP-N-acetylglucosamine)
8 Cited Publications
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Based on 8 publication(s) in Google Scholar

UDP-GlcNAc (UDP-N-Acetyl-D-glucosamine) is an important component and precursor of bacterial peptidoglycan. UDP-GlcNAc is a nucleotide sugar used by Glycosyltransferases to synthesize glycoproteins, glycosaminoglycans, glycolipids, and glycoRNA. UDP-GlcNAc also serves as the donor substrate for forming O-GlcNAc, a dynamic intracellular protein modification involved in diverse signaling and disease processes. UDP-GlcNAc is the sugar nucleotide donor for the synthesis of O-GlcNAc modified proteins. UDP-GlcNAc also acts as a full agonist of the P2Y14 receptor and inhibits the formation of cAMP. UDP-GlcNAc can be used in studies related to bacterial infections.

For research use only. We do not sell to patients.

  • CAS No.: 528-04-1
  • Formula: C17H27N3O17P2
  • Molecular Weight:607.35
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • UDP-GlcNAc Chemical Structure
    UDP-GlcNAc Chemical Structure
  • Experimental Validation Results for UDP-GlcNAc
  • Experimental Validation Results for UDP-GlcNAc
  • Experimental Validation Results for UDP-GlcNAc
CAS No.: 528-04-1
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Cell Proliferation/Viability AssayApoptosis AnalysisWB
  • Cell Proliferation/Viability Assay
  • Apoptosis Analysis
  • WB

All P2Y Receptor Isoforms

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All Endogenous Metabolite Isoforms

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  • UDP-GlcNAc Chemical Structure
    UDP-GlcNAc Chemical Structure
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    UDP-GlcNAc purchased from MedChemExpress. Usage Cited in: Cancer Res. 2025 Mar 14;85(6):1113-1129. [Abstract]

    Customer Validation
     MTHFD2 knockdown cells and control cells were treated with sunitinib (10 μM) and UDP-GlcNAc (10 μM) for 48 hours. Cell viability (n = 3).

  • 1/16

    UDP-GlcNAc purchased from MedChemExpress. Usage Cited in: Cancer Res. 2025 Mar 14;85(6):1113-1129. [Abstract]

    Customer Validation
     MTHFD2 knockdown cells and control cells were treated with sunitinib (10 μmol/L) and UDP-GlcNAc (10 μmol/L) for 48 hours. Cell apoptosis (n = 3) were used to assess the killing capacity of sunitinib. PI, propidium iodide. G, Relative levels of metabolites in MTHFD2 knockdown cells measured by untargeted metabolomics (n = 6). F6P, fructose-6-phosphate;

  • 1/16

    UDP-GlcNAc purchased from MedChemExpress. Usage Cited in: Cancer Res. 2025 Mar 14;85(6):1113-1129. [Abstract]

    Customer Validation
     Immunoblotting analysis of whole cell lysate (input) and His pull-down products derived from 786O cells transfected with indicated constructs and treated with MG132 (10 μmol/L) for 6 hours after cells were treated with or without UDP-GlcNAc (10 μM) for 24 hours. NC, negative control. The results showed that UDP-GlcNAc could reverse the increased c-MYC ubiquitination resulting from the silencing of MTHFD2 expression.

  • UDP-GlcNAc