2. Metabolic Enzyme/Protease GPCR/G Protein Others Epigenetics
  3. Endogenous Metabolite P2Y Receptor Drug Intermediate Glycosyltransferase
  4. UDP-GlcNAc

UDP-GlcNAc  (Synonyms: UDP-N-Acetyl-D-glucosamine; Uridine diphospho-N-acetylglucosamine; UDP-N-acetylglucosamine)

Cat. No.: HY-148596
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UDP-GlcNAc (UDP-N-Acetyl-D-glucosamine) is an important component and precursor of bacterial peptidoglycan. UDP-GlcNAc is a nucleotide sugar used by Glycosyltransferases to synthesize glycoproteins, glycosaminoglycans, glycolipids, and glycoRNA. UDP-GlcNAc also serves as the donor substrate for forming O-GlcNAc, a dynamic intracellular protein modification involved in diverse signaling and disease processes. UDP-GlcNAc is the sugar nucleotide donor for the synthesis of O-GlcNAc modified proteins. UDP-GlcNAc also acts as a full agonist of the P2Y14 receptor and inhibits the formation of cAMP. UDP-GlcNAc can be used in studies related to bacterial infections.

For research use only. We do not sell to patients.

CAS No. : 528-04-1

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Other In-stock Forms of UDP-GlcNAc:

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UDP-GlcNAc Related Antibodies

Top Publications Citing Use of Products

    UDP-GlcNAc purchased from MedChemExpress. Usage Cited in: Cancer Res. 2025 Mar 14;85(6):1113-1129.  [Abstract]

    MTHFD2 knockdown cells and control cells were treated with sunitinib (10 μM) and UDP-GlcNAc (10 μM) for 48 hours. Cell viability (n = 3).

    UDP-GlcNAc purchased from MedChemExpress. Usage Cited in: Cancer Res. 2025 Mar 14;85(6):1113-1129.  [Abstract]

    MTHFD2 knockdown cells and control cells were treated with sunitinib (10 μmol/L) and UDP-GlcNAc (10 μmol/L) for 48 hours. Cell apoptosis (n = 3) were used to assess the killing capacity of sunitinib. PI, propidium iodide. G, Relative levels of metabolites in MTHFD2 knockdown cells measured by untargeted metabolomics (n = 6). F6P, fructose-6-phosphate;

    UDP-GlcNAc purchased from MedChemExpress. Usage Cited in: Cancer Res. 2025 Mar 14;85(6):1113-1129.  [Abstract]

    Immunoblotting analysis of whole cell lysate (input) and His pull-down products derived from 786O cells transfected with indicated constructs and treated with MG132 (10 μmol/L) for 6 hours after cells were treated with or without UDP-GlcNAc (10 μM) for 24 hours. NC, negative control. The results showed that UDP-GlcNAc could reverse the increased c-MYC ubiquitination resulting from the silencing of MTHFD2 expression.

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    Human Endogenous Metabolite Microbial Metabolite

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    P2Y1 Receptor P2Y2 Receptor P2Y6 Receptor P2Y11 Receptor P2Y12 Receptor P2Y13 Receptor P2Y14 Receptor

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    Description

    UDP-GlcNAc (UDP-N-Acetyl-D-glucosamine) is an important component and precursor of bacterial peptidoglycan. UDP-GlcNAc is a nucleotide sugar used by Glycosyltransferases to synthesize glycoproteins, glycosaminoglycans, glycolipids, and glycoRNA. UDP-GlcNAc also serves as the donor substrate for forming O-GlcNAc, a dynamic intracellular protein modification involved in diverse signaling and disease processes. UDP-GlcNAc is the sugar nucleotide donor for the synthesis of O-GlcNAc modified proteins. UDP-GlcNAc also acts as a full agonist of the P2Y14 receptor and inhibits the formation of cAMP. UDP-GlcNAc can be used in studies related to bacterial infections[1][2][3].

    IC50 & Target[1]

    P2Y14 Receptor

     

    In Vitro

    UDP-GlcNAc acts as a full agonist of the hP2Y14 receptor in P2Y14-HEK293 cells, inhibiting Forskolin-stimulated cAMP accumulation with an EC50 of 919 nM and a maximum inhibition rate of 58%[2].
    UDP-GlcNAc (at different concentrations; 15 min) acts as a full agonist of the hP2Y14 receptor in P2Y14-C6 rat glioma cells, inhibiting Forskolin-stimulated cAMP accumulation with an EC50 of 225 nM and a maximum inhibition rate of 74%[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    UDP-GlcNAc Related Antibodies
    Molecular Weight

    607.35

    Formula

    C17H27N3O17P2
    CAS No.
    SMILES

    O[C@H]1[C@@H](O)[C@H](N2C(NC(C=C2)=O)=O)O[C@@H]1COP(OP(O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)NC(C)=O)(O)=O)(O)=O
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    UDP-GlcNAc Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    UDP-GlcNAc528-04-1UDP-N-Acetyl-D-glucosamine Uridine diphospho-N-acetylglucosamine UDP-N-acetylglucosamineEndogenous MetaboliteP2Y ReceptorDrug IntermediateGlycosyltransferaseDrug Iintermediatehuman P2Y14 receptorlipopolysaccharidesbacterial peptidoglycankanamycinteichoic acidglycoproteinsneomycineukaryotic chitinP2Y14-HEK293 cellsgentamycinInhibitorinhibitorinhibit

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