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Cat. No.: HY-W477597

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BZX2

BZX2 is an irreversible covalent inhibitor of O-GlcNAc transferase (OGT) with an IC₅₀ of <10 µM. BZX2 is cell-permeable but exhibits multiple off-target effects.

For research use only. We do not sell to patients.

CAS No.: 1349070-58-1
Formula: C₁₇H₁₃NO₆
Molecular Weight:327.29

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

BZX2 Chemical Structure

CAS No.: 1349070-58-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

BZX2 is an irreversible covalent inhibitor of O-GlcNAc transferase (OGT) with an IC₅₀ of <10 µM. BZX2 is cell-permeable but exhibits multiple off-target effects^[1].

Chemical Information

CAS No. 1349070-58-1
Molecular Weight 327.29
Formula C₁₇H₁₃NO₆
SMILES

O=C(OC1=CC=C(OC)C=C1)N2C(=O)OC3=CC(=CC=C32)C(=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Eekelen K. New scaffolds for O-GlcNAc transferase inhibition, by hit and synthetic route optimisation. 2023.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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