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PG 34 is a weak O-GlcNAc transferase (OGT) inhibitor (IC50=68 μM), and a close structural analog of OSMI-1 (HY-119738).

For research use only. We do not sell to patients.

PG 34 Chemical Structure

PG 34 Chemical Structure

CAS No. : 1681056-62-1

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Based on 1 publication(s) in Google Scholar

PG 34 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

PG 34 is a weak O-GlcNAc transferase (OGT) inhibitor (IC50=68 μM), and a close structural analog of OSMI-1 (HY-119738)[1].

In Vitro

PG34 (0.5-50 µM; 24 h) shows no detectable inhibition of OGT in CHO cells, displays no effect on apoptotic signaling, and shows a moderate effect on cell viability only at the highest concentration[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PG 34 Related Antibodies

Cell Viability Assay[1]

Cell Line: CHO cells
Concentration: 0.5-50 µM
Incubation Time: 24 hours
Result: Inhibited cell growth moderately at 50 µM.

Western Blot Analysis[1]

Cell Line: CHO cells
Concentration: 10, 25, and 50 µM
Incubation Time: 24 hours
Result: Showed no reduction in global O-GlcNAcylation in cells.
Molecular Weight

547.65

Formula

C28H25N3O5S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1)C=CC2=C1C=CC(S(N[C@H](CC3=CC=CC=C3)C(N(CC4=CC=CO4)CC5=CC=CS5)=O)(=O)=O)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (182.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8260 mL 9.1299 mL 18.2598 mL
5 mM 0.3652 mL 1.8260 mL 3.6520 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8260 mL 9.1299 mL 18.2598 mL 45.6496 mL
5 mM 0.3652 mL 1.8260 mL 3.6520 mL 9.1299 mL
10 mM 0.1826 mL 0.9130 mL 1.8260 mL 4.5650 mL
15 mM 0.1217 mL 0.6087 mL 1.2173 mL 3.0433 mL
20 mM 0.0913 mL 0.4565 mL 0.9130 mL 2.2825 mL
25 mM 0.0730 mL 0.3652 mL 0.7304 mL 1.8260 mL
30 mM 0.0609 mL 0.3043 mL 0.6087 mL 1.5217 mL
40 mM 0.0456 mL 0.2282 mL 0.4565 mL 1.1412 mL
50 mM 0.0365 mL 0.1826 mL 0.3652 mL 0.9130 mL
60 mM 0.0304 mL 0.1522 mL 0.3043 mL 0.7608 mL
80 mM 0.0228 mL 0.1141 mL 0.2282 mL 0.5706 mL
100 mM 0.0183 mL 0.0913 mL 0.1826 mL 0.4565 mL
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PG 34 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PG 341681056-62-1PG34PG-34OthersCHO cellInhibitorinhibitorinhibit

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