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OSMI-4 

Cat. No.: HY-114361 Purity: 99.82%
Handling Instructions

OSMI-4 is a low nanomolar O-GlcNAc transferase (OGT) inhibitor, with an EC50 of 3 μM in cells.

For research use only. We do not sell to patients.

OSMI-4 Chemical Structure

OSMI-4 Chemical Structure

CAS No. : 2260791-14-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 864 In-stock
Estimated Time of Arrival: December 31
5 mg USD 650 In-stock
Estimated Time of Arrival: December 31
10 mg USD 950 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2950 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3950 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

OSMI-4 is a low nanomolar O-GlcNAc transferase (OGT) inhibitor, with an EC50 of 3 μM in cells.

IC50 & Target

EC50: 3 μM (OGT)[1].

In Vitro

OSMI-4 (4b) is the best OGT inhibitor reported to date, with a ∼3 μM EC50 in cells, making it especially attractive for probing OGT’s complex biology[1].

Molecular Weight

604.09

Formula

C₂₇H₂₆ClN₃O₇S₂

CAS No.

2260791-14-6

SMILES

O=C1C=CC2=C(C=C(Cl)C(S(N[[email protected]@H](C(N(CC(OCC)=O)CC3=CC=CS3)=O)C4=C(OC)C=CC=C4)(=O)=O)=C2)N1

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (103.46 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6554 mL 8.2769 mL 16.5538 mL
5 mM 0.3311 mL 1.6554 mL 3.3108 mL
10 mM 0.1655 mL 0.8277 mL 1.6554 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.44 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.44 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.82%

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OSMI-4
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HY-114361
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