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OSMI-4 

Cat. No.: HY-114361
Handling Instructions

OSMI-4 is a low nanomolar O-GlcNAc transferase (OGT) inhibitor, with an EC50 of 3 μM in cells.

For research use only. We do not sell to patients.

OSMI-4 Chemical Structure

OSMI-4 Chemical Structure

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Customer Review

  • Biological Activity

  • Technical Information

  • References

Description

OSMI-4 is a low nanomolar O-GlcNAc transferase (OGT) inhibitor, with an EC50 of 3 μM in cells.

IC50 & Target

EC50: 3 μM (OGT)[1].

In Vitro

OSMI-4 (4b) is the best OGT inhibitor reported to date, with a ∼3 μM EC50 in cells, making it especially attractive for probing OGT’s complex biology[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6554 mL 8.2769 mL 16.5538 mL
5 mM 0.3311 mL 1.6554 mL 3.3108 mL
10 mM 0.1655 mL 0.8277 mL 1.6554 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

604.09

Formula

C₂₇H₂₆ClN₃O₇S₂

SMILES

O=C1C=CC2=C(C=C(Cl)C(S(N[[email protected]@H](C(N(CC(OCC)=O)CC3=CC=CS3)=O)C4=C(OC)C=CC=C4)(=O)=O)=C2)N1

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
OSMI-4
Cat. No.:
HY-114361
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OSMI-4

Cat. No.: HY-114361