TET3 - tet methylcytosine dioxygenase 3 Gene

Also Known as BEFAHRS; hCG_40738

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 200424

About TET3

Cytogenetic location: 2p13.1 Genomic coordinates (GRCh38): 2:73,983,631-74,135,498 (from NCBI)

This gene has 4 transcripts (splice variants), 208 orthologues, 2 paralogues and is associated with 3 phenotypes. Ubiquitous expression in bone marrow (RPKM 6.8), skin (RPKM 6.6) and 23 other tissues.

Summary

Members of the ten-eleven translocation (TET) gene family, including TET3, play a role in the DNA methylation process (Langemeijer et al., 2009 [PubMed 19923888]).[supplied by OMIM, Nov 2010]

TET3 Products (2)

mRNA Protein Name
NM_001287491.2 NP_001274420.1 methylcytosine dioxygenase TET3 isoform 1
NM_001366022.1 NP_001352951.1 methylcytosine dioxygenase TET3 isoform 2

TET3 Protein Structure

Tet_JBP

Tet_JBP: Oxygenase domain of the 2OGFeDO superfamily (850 - 1562)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1660 a.a.
Protein Preferred Names Protein Names

methylcytosine dioxygenase TET3

  • probable methylcytosine dioxygenase TET3

TET3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TET3 O43151 OGT Homo sapiens O15294
Pull Down
23353889
Intra
TET3 O43151 OGT Homo sapiens O15294
Anti Bait CoIP
23353889
Intra
TET3 O43151 OGT Homo sapiens O15294
Anti Bait CoIP
23222540
Intra
TET3 O43151 OGT Homo sapiens O15294
Anti Tag CoIP
23222540
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Beck-Fahrner Syndrome

  • BEFAHRS
Plasma Cell Neoplasm

  • Plasma Cell Dyscrasia

  • Paraproteinemias

  • Plasma Cell Tumour

  • Plasmacytic Tumor

  • Multiple Myeloma

  • Plasmacytoma

  • Plasma Cell Tumours

  • Plasma Cells Dyscrasia
Myeloma, Multiple

  • Multiple Myeloma

  • Plasma Cell Myeloma

  • Kahler Disease

  • Myelomatosis

  • Medullary Plasmacytoma

  • Multiple Myeloma, Resistance To

  • Myeloma

  • Plasma Cell Dyscrasia

  • Kahler'S Disease

  • Multiple Myeloma, Susceptibility To

  • Myeloma - Multiple

  • Kahler-Bozzolo Disease

  • Plasma Cell Myelomas

  • MM

  • Plasma Cell Neoplasm

  • Primary Systemic Amyloidosis

  • Primary Amyloidosis

  • Immunoglobulin Deposition Disease

  • Plasmacytic Myeloma

  • Multiple Myelomata

  • Multiple Myeloma Nos

  • Multiple Myeloma Without Mention Of Remission

  • Monostotic Plasma Cell Myeloma

  • Mm - [Multiple Myeloma]
Syndromic X-Linked Intellectual Disability Nascimento Type

  • Mental Retardation, X-Linked Syndromic, Nascimento-Type

  • X-Linked Intellectual Disability-Nail Dystrophy-Seizures Syndrome
Rett Syndrome

  • Atypical Rett Syndrome

  • RTT

  • Rett Disorder

  • Rts

  • Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use

  • Rett Syndrome, Preserved Speech Variant

  • Rett Syndrome, Atypical

  • Rett'S Disorder

  • Rett Syndrome Variant

  • Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome

  • Cerebroatrophic Hyperammonemia

  • Rett Like Syndrome

  • Rett'S Syndrome

  • Atypical Rtt

  • Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use

  • Rett Syndrome Preserved Speech Variant

  • Rett Syndrome Zappella Variant

  • Rett Syndrome, Zappella Variant
Holoprosencephaly 2

  • HPE2

  • Holoprosencephaly-2

  • Holoprosencephaly, Type 2
Non-Syndromic X-Linked Intellectual Disability 93

  • Mrx93

  • X-Linked Mental Retardation With Macrocephaly
Cerebellar Ataxia, Deafness, And Narcolepsy, Autosomal Dominant

  • Autosomal Dominant Cerebellar Ataxia, Deafness And Narcolepsy

  • ADCADN

  • Autosomal Dominant Cerebellar Ataxia, Deafness, And Narcolepsy

  • Adca-Dn Syndrome

  • Autosomal Dominant Cerebellar Ataxia-Deafness-Narcolepsy Syndrome

  • Adca-Dn

  • Autosomal Dominant Cerebellar Ataxia-Hearing Loss-Narcolepsy Syndrome

  • Ataxia, Cerebellar, Deafness, And Narcolepsy, Autosomal Dominant
Tatton-Brown-Rahman Syndrome

  • TBRS

  • Dnmt3a Overgrowth Syndrome

  • Tatton-Brown-Rahman Overgrowth Syndrome

  • Dos

  • Dnmt3a-Related Overgrowth Syndrome

  • Doid:0112339

  • Dose
Chronic Leukemia

  • Adult Chronic Leukemia

  • Cll

  • Cml
Chronic Myelomonocytic Leukemia

  • Leukemia, Myelomonocytic, Chronic

  • Cmml

  • Leukemia Myelomonocytic Chronic

  • Cmml - [Chronic Myelomonocytic Leukaemia]

  • Chronic Myelomonocytic Leukaemia Without Mention Of Remission

  • Chronic Monocytic Leukaemia

  • Chronic Monocytoid Leukaemia
Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome

  • Icf Syndrome

  • Immunodeficiency Syndrome, Variable

  • Ciid

  • Centromeric Instability, Immunodeficiency Syndrome

  • Immune Deficiency, Variable, With Centromeric Instability Of Chromosomes 1, 9, And 16

  • Icf
Leukemia, Acute Myeloid

  • Acute Myeloid Leukemia

  • Leukemia, Acute Myelogenous

  • Acute Myelogenous Leukemia

  • AML

  • Leukemia, Acute Myeloid, Susceptibility To

  • Acute Myeloblastic Leukemia

  • Leukemia, Acute Myeloid, Reduced Survival In, Somatic

  • Acute Myeloid Leukaemia

  • Leukemia, Myelocytic, Acute

  • Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

  • Secondary Aml

  • Acute Myelocytic Leukemia

  • Acute Myeloid Leukemia, Somatic

  • Leukemia, Acute Myeloid, Somatic

  • Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

  • Acute Myeloblastic Leukaemia

  • Acute Myelogenous Leukaemia

  • Aml - Acute Myeloid Leukemia

  • Acute Myeloid Leukemia With Cebpa Somatic Mutations

  • Aml With Cebpa Somatic Mutations

  • Inherited Acute Myeloid Leukemia

  • Familial Aml

  • Inherited Aml

  • Pure Familial Aml

  • Pure Familial Acute Myeloid Leukemia

  • Secondary Acute Myeloid Leukemia

  • Therapy-Related Aml And Myelodysplastic Syndrome

  • Acute Myeloid Leukemia, Secondary

  • Acute Non-Lymphoblastic Leukemia

  • Acute Non-Lymphocytic Leukemia

  • Acute Biphenotypic Leukemia

  • Acute Undifferentiated Leukemia

  • Acute Myeloblastic Leukaemia With Multilineage Dysplasia

  • Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

  • Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-402410 TETi76 Inhibitor 97.49% Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TET3 RGD RGD:1590584
Bos taurus TET3 VGNC VGNC:54499
Mus musculus TET3 MGD MGI:2446229
Felis catus TET3 VGNC VGNC:66094
Canis familiaris TET3 VGNC VGNC:47262
Macaca mulatta TET3 VGNC VGNC:106232
Others TET3 NCBI