TET2 - tet methylcytosine dioxygenase 2 Gene

Also Known as MDS; IMD75; KIAA1546

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54790

About TET2

Cytogenetic location: 4q24 Genomic coordinates (GRCh38): 4:105,145,875-105,279,803 (from NCBI)

This gene has 9 transcripts (splice variants), 199 orthologues, 2 paralogues and is associated with 160 phenotypes. Ubiquitous expression in bone marrow (RPKM 5.5), appendix (RPKM 4.6) and 25 other tissues.

Summary

The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The encoded protein is involved in myelopoiesis, and defects in this gene have been associated with several myeloproliferative disorders. Two variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

TET2 Products (2)

mRNA	Protein	Name
NM_001127208.3	NP_001120680.1	methylcytosine dioxygenase TET2 isoform a
NM_017628.4	NP_060098.3	methylcytosine dioxygenase TET2 isoform b

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables 5-methylcytosine dioxygenase activity	IDA IDA: Inferred from direct assay	24315485	GOA
enables 5-methylcytosine dioxygenase activity	IMP IMP: Inferred from mutant phenotype	21057493	GOA
enables ferrous iron binding	IDA IDA: Inferred from direct assay	24315485	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23222540	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	24315485	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in leukocyte differentiation	IMP IMP: Inferred from mutant phenotype	32518946	GOA
involved in myeloid cell differentiation	IMP IMP: Inferred from mutant phenotype	21057493	GOA
involved in positive regulation of gene expression via chromosomal CpG island demethylation	IDA IDA: Inferred from direct assay	24315485	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	23222540	GOA
involved in protein O-linked glycosylation	IDA IDA: Inferred from direct assay	23222540	GOA
involved in protein O-linked glycosylation	IMP IMP: Inferred from mutant phenotype	23353889	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TET2 Protein Structure

Tet_JBP

0
400
800
1200
1600
2002 a.a.

Protein Preferred Names	Protein Names
methylcytosine dioxygenase TET2	probable methylcytosine dioxygenase TET2

TET2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TET2	Q6N021	WT1	Homo sapiens	P19544	Pull Down	25601757
Intra	TET2	Q6N021	WT1	Homo sapiens	P19544	Anti Tag CoIP	25601757
Intra	TET2	Q6N021	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	TET2	Q6N021	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	TET2	Q6N021	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	TET2	Q6N021	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	TET2	Q6N021	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	TET2	Q6N021	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	TET2	Q6N021	OGT	Homo sapiens	O15294	Pull Down	23353889
Intra	TET2	Q6N021	OGT	Homo sapiens	O15294	Anti Tag CoIP	23353889
Intra	TET2	Q6N021	SEMG1	Homo sapiens	P04279	Anti Tag CoIP	33961781
Intra	TET2	Q6N021	SEMG1	Homo sapiens	P04279	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

TET2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84639	TET2 Antibody (YA4336)	WB, IHC-P, ICC/IF, FC, ELISA	Human
HY-P84639A	TET2 Antibody (YA4336)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human

Related Diseases

Diseases	Alias
Immunodeficiency 75	IMD75
Myelodysplastic Syndrome	Myelodysplastic Syndromes Myelodysplasia MDS Myelodysplastic Syndrome Included Myelodysplastic Syndrome, Susceptibility To, Included Myelodysplastic Syndrome, Somatic Myelodysplastic Syndrome, Susceptibility To
Refractory Anemia	Anemia Refractory Refractory Anemias Refractory Anemia, Without Ringed Sideroblasts, Without Excess Blasts Refractory Anaemia Without Sideroblasts Refractory Anaemia With Sideroblasts Acquired Idiopathic Sideroblastic Anaemia Primary Acquired Sideroblastic Anaemia Refractory Sideroblastic Anaemia Refractory Anaemia With Excess Blasts Raeb - [Refractory Anaemia With Excess Blasts] Nos Raeb - [Refractory Anaemia With Excess Blasts] Rars-T [Refractory Anaemia With Ringed Sideroblasts Associated With Marked Thrombocytosis]
Refractory Anemia With Excess Blasts Type 2	Raeb-2 Refractory Anemia With Excess Blasts Ii
Refractory Anemia With Excess Blasts Type 1	Raeb-1 Refractory Anemia With Excess Blasts I
Aml With Myelodysplasia-Related Features	Acute Myeloid Leukemia With Multilineage Dysplasia Aml With Multilineage Dysplasia Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Aggressive Systemic Mastocytosis	Asm Lymphadenopathic Mastocytosis With Eosinophilia
Autosomal Recessive Pyridoxine-Refractory Sideroblastic Anemia 2	Refractory Anemia With Ringed Sideroblasts Acquired Idiopathic Sideroblastic Anemia Aisa Primary Acquired Sideroblastic Anemia Autosomal Recessive Pyridoxine-Refractory Sideroblastic Anaemia 2 Pyridoxine-Refractory Autosomal Recessive Sideroblastic Anaemia Pyridoxine-Refractory Autosomal Recessive Sideroblastic Anemia Sideroblastic Anemia Pyridoxine-Refractory Autosomal Recessive Pyridoxine Refractory Sideroblastic Anemia
Systemic Mastocytosis With Associated Hematologic Neoplasm	Systemic Mastocytosis With An Associated Clonal Hematologic Non-Mast Cell Lineage Disease Sm-Ahn Sm-Ahnmd Systemic Mastocytosis With Associated Clonal, Hematologic Non-Mast-Cell Lineage Disease
Polycythemia Vera	PV Polycythemia Rubra Vera Prv Osler-Vaquez Disease Chronic Erythremia Polycythaemia Rubra Vera Primary Polycythemia Vaquez Disease Polycythemia Vera, Somatic Osler-Vaquez Syndrome Proliferative Polycythaemia Polycythemia Ruba Vera Acquired Primary Erythrocytosis Heilmeyer-Schoner Disease Vaquez Osler Disease Primary Polycythaemia
Myelofibrosis	Primary Myelofibrosis Agnogenic Myeloid Metaplasia Idiopathic Myelofibrosis Myeloid Metaplasia Myelofibrosis With Myeloid Metaplasia Osteomyelofibrosis Megakaryocytic Myelosclerosis Myelosclerosis Chronic Idiopathic Myelofibrosis Myelofibrosis, Idiopathic Myelofibrosis With Myeloid Metaplasia, Somatic Myelofibrosis, Somatic Aleukemic Myelosis Bone Marrow Fibrosis MYELOF MMM Agnogenic Myeloid Metaplasia With Myelofibrosis Ammm Myelosclerosis With Myeloid Metaplasia Myelofibrosis Nos
Essential Thrombocythemia	Essential Thrombocytosis Familial Thrombocytosis Hemorrhagic Thrombocythemia Hereditary Thrombocythemia Primary Thrombocytosis Idiopathic Thrombocythemia Primary Thrombocythemia Thrombocythemia, Essential Essential Thrombocythaemia Et Familial Thrombocythemia Thrombocythemia Essential
Systemic Mastocytosis	Systemic Mast Cell Disease Systemic Tissue Mast Cell Disease Mastocytosis, Systemic Smcd - Systemic Mast Cell Disease Smcd Mast Cell Disease, Systemic Systemic Mast-Cell Disease Systemic Mastocytoses Mastocytosis Systemic Corneal Dystrophy, Subepithelial Mucinous Smcd - [Systemic Mast Cell Disease]
Mastocytosis	Mast Cell Disease Mast Cell Hyperplasia Urticaria Pigmentosa Malignant Mastocytoma Malignant Mast Cell Tumours Malignant Mastocytosis
Thrombocytosis	Thrombocythaemia
Chronic Myelomonocytic Leukemia	Leukemia, Myelomonocytic, Chronic Cmml Leukemia Myelomonocytic Chronic Cmml - [Chronic Myelomonocytic Leukaemia] Chronic Myelomonocytic Leukaemia Without Mention Of Remission Chronic Monocytic Leukaemia Chronic Monocytoid Leukaemia
Plasma Cell Neoplasm	Plasma Cell Dyscrasia Paraproteinemias Plasma Cell Tumour Plasmacytic Tumor Multiple Myeloma Plasmacytoma Plasma Cell Tumours Plasma Cells Dyscrasia
Polycythemia	Erythrocythemia Polycythemia Vera Polycythaemia Due To High Altitude
Myeloma, Multiple	Multiple Myeloma Plasma Cell Myeloma Kahler Disease Myelomatosis Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Kahler'S Disease Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Refractory Anemia With Excess Blasts	Raeb
Refractory Cytopenia With Multilineage Dysplasia
Mastocytosis, Cutaneous	Urticaria Pigmentosa Cutaneous Mastocytosis Diffuse Cutaneous Mastocytosis Maculopapular Cutaneous Mastocytosis Mastocytosis, Diffuse Cutaneous MASTC Mastocytosis, Maculopapular Cutaneous Mastocytosis, Systemic, Somatic Mastocytoma Dcm Diffuse Cutaneous Maculopapulous Mastocytosis Up/Mpcm Cm Mastocytosis, Systemic MASTSYS Mast Cell Disease Mast-Cell Disease Mast Cell Leukemia Mastocytosis, Indolent Mastocytosis With Associated Hematologic Disorder Mast Cell Neoplasm Benign Mastocytoma
Angioimmunoblastic T-Cell Lymphoma	Immunoblastic Lymphadenopathy Lymphogranulomatosis X T-Cell Lymphoma, Aild Type Aitl Ailt Angioimmunoblastic Lymphadenopathy Aild - [Angioimmunoblastic Lymphadenopathy With Dysproteinaemia] Angioimmunoblastic Lymphoma
Myeloid Leukemia	Myeloid Leukaemia Leukaemia Myelogenous Leukemia Myelogenous Myeloid Granulocytic Leukaemia Myeloid Granulocytic Leukemia Non-Lymphocytic Leukemia Leukemia, Myeloid Granulocytic Leukaemia Myelogenous Leukaemia Myeloid Leukaemia, Unspecified, Without Mention Of Remission
Myeloproliferative Neoplasm	Myeloproliferative Disorder Chronic Myeloproliferative Disease Myeloproliferative Neoplasms Chronic Myeloproliferative Disorder Cmpd Cmpd, U Chronic Myeloproliferative Disorders Mpd Mpn Myeloproliferative Disorders Myeloproliferative Disease Campomelic Dysplasia
Juvenile Myelomonocytic Leukemia	Leukemia, Juvenile Myelomonocytic JMML Leukemia, Juvenile Myelomonocytic, Somatic Juvenile Chronic Myelomonocytic Leukemia Juvenile Chronic Myelogenous Leukemia Leukemia, Myelomonocytic, Juvenile Juvenile Myelomonocytic Leukaemia Without Mention Of Remission
Adult Spinal Cord Glioblastoma Multiforme	Glioblastoma Multiforme Of Spinal Cord Adult Spinal Cord Glioblastoma
Sm-Ahnmd	Systemic Mastocytosis With Associated Clonal, Hematologic Non-Mast-Cell Lineage Disease Systemic Mastocytosis With Associated Clonal Haematological Non-Mast Cell Lineage Disease Systemic Mastocytosis With Associated Clonal Hematological Non-Mast-Cell Lineage Disease
Chronic Leukemia	Adult Chronic Leukemia Cll Cml
Vexas Syndrome	VEXAS Vexas Syndrome, Somatic Vacuoles, E1 Enzyme, X-Linked, Autoinflammatory And Somatic Syndrome Vacuoles, E1 Enzyme, X-Linked, Autoinflammatory, Somatic Syndrome Vacuoles, E1 Enzyme, X-Linked, Autoinflammatory, Somatic
Lymphoma	Lymphoid Cancer Lymphomas Lymphoid Cancers Lymphoid Neoplasm Lymphoma Nos Nhl - [Non-Hodgkin Lymphoma] Non-Hodgkin Lymphoma Non-Hodgkin Lymphoma, Nos Non-Hodgkin Malignant Lymphoma Nos
Atypical Chronic Myeloid Leukemia, Bcr-Abl1 Negative	Atypical Chronic Myeloid Leukemia Atypical Chronic Myeloid Leukaemia Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Acml Atypical Chronic Myeloid Leukaemia Bcr-Abl1 Negative Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Atypical Cml Subacute Myeloid Leukemia Subacute Myelogenous Leukaemia Subacute Myeloid Leukaemia Subacute Myelosis Atypical Chronic Myeloid Leukaemia, Bcr-Abl-Negative Without Mention Of Remission Subacute Monocytic Leukaemia Without Mention Of Remission Subacute Monocytic Leukaemia
Myelodysplastic/Myeloproliferative Neoplasm	Myelodysplastic-Myeloproliferative Diseases Myelodysplastic/Myeloproliferative Disease Myelodysplastic Myeloproliferative Cancer Myelodysplastic Myeloproliferative Disease Myeloproliferative/Myelodysplastic Syndromes
Myelophthisic Anemia	Myelophthisis Anemia Leukoerythroblastic Anemia, Leukoerythroblastic Leukoerythroblastosis Anemia, Myelophthisic Leukoerythroblastic Anemia
Bone Marrow Cancer	Malignant Neoplasm Of Bone Marrow Bone Marrow Neoplasm Bone Marrow Tumor Malignant Bone Marrow Tumor Myeloproliferative Disorders Bone Marrow Neoplasms Myeloproliferative Disease Chronic Myeloproliferative Disorder
Chronic Neutrophilic Leukemia	Cnl Leukemia Neutrophilic Chronic
Core Binding Factor Acute Myeloid Leukemia	Cbf Acute Myeloid Leukemia Cbf-Aml Core-Binding Factor Aml
Chronic Eosinophilic Leukemia	Pdgfra-Associated Chronic Eosinophilic Leukemia
Extracutaneous Mastocytoma	Mastocytoma Mast Cell Neoplasm Benign Mastocytoma
Mature T-Cell And Nk-Cell Lymphoma	Mature T-Cell And Natural Killer Cell Lymphoma Nk-T Cell Lymphoma
Acute Myeloid Leukemia With Bcr-Abl1	Acute Myeleoid Leukemia With Bcr-Abl1
Diamond-Blackfan Anemia 11	DBA11 Rpl26-Related Diamond-Blackfan Anemia Anemia, Diamond-Blackfan, Type 11
Rett Syndrome	Atypical Rett Syndrome RTT Rett Disorder Rts Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use Rett Syndrome, Preserved Speech Variant Rett Syndrome, Atypical Rett'S Disorder Rett Syndrome Variant Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome Cerebroatrophic Hyperammonemia Rett Like Syndrome Rett'S Syndrome Atypical Rtt Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Rett Syndrome Preserved Speech Variant Rett Syndrome Zappella Variant Rett Syndrome, Zappella Variant
Tatton-Brown-Rahman Syndrome	TBRS Dnmt3a Overgrowth Syndrome Tatton-Brown-Rahman Overgrowth Syndrome Dos Dnmt3a-Related Overgrowth Syndrome Doid:0112339 Dose
Hypoascorbemia	Scurvy Ascorbic Acid Deficiency Vitamin C Deficiency Vitamin C, Inability To Synthesize Deficiency Of Vitamin C Scorbutus Vitamin C
T-Cell Adult Acute Lymphocytic Leukemia	Acute Adult T-Cell Leukemia-Lymphoma Adult Precursor T Lymphoblastic Leukemia Atll T-Cell Adult Acute Lymphoblastic Leukemia
Multiple Enchondromatosis, Maffucci Type	Maffucci Syndrome Chondrodysplasia With Hemangioma Chondroplasia Angiomatosis Enchondromatosis With Hemangiomata Hemangiomatosis Chondrodystrophica Kast Syndrome Multiple Angiomas And Endochondromas Dyschondrodysplasia With Hemangiomas Enchondromatosis Type Ii Enchondromatosis With Multiple Cavernous Hemangiomas Dyschondroplasia And Cavernous Hemangioma Hemangiomata With Dyschondroplasia
Alcohol Dependence	Alcoholism Alcohol Dependence, Susceptibility To Alcohol Dependence, Protection Against Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against Alcoholism, Susceptibility To Alcoholic Intoxication, Chronic Pharyngeal Neoplasms Chronic Alcoholism Dipsomania Alcohol Addiction Ethanol Dependence Chronic Ethanolism Chronic Alcoholic Disease Nos Alcoholic Disease Nos Alcoholic
Hematuria, Benign Familial	Benign Familial Hematuria BFH Thin Membrane Nephropathy Tmn Thin Basement Membrane Nephropathy Thin-Basement-Membrane Nephropathy Hematuria, Familial Benign Hematuria Benign Familial Hematuria, Benign, Familial Thin Basement Membrane Disease
Enchondromatosis, Multiple, Ollier Type	Ollier Disease Enchondromatosis Dyschondroplasia Osteochondromatosis Multiple Cartilaginous Enchondroses Multiple Enchondromatosis Enchondromatosis With Haemangiomata Enchondromatosis, Multiple Kast'S Syndrome Ollier'S Syndrome Enchondromatosis Multiple ENCHOM Maffucci Disease Olliers Disease Hereditary Multiple Exostoses Chondromatosis
Malignant Histiocytic Disease	Histiocytic Disorders, Malignant
Blood Platelet Disease	Platelet Disorder Blood Platelet Disorders Thrombocytopathy Platelet Dysfunction Platelet Disorders Qualitative Platelet Deficiency
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic
Wilms Tumor 1	Nephroblastoma Wilms Tumor WT1 Wilms' Tumor Bilateral Wilms Tumor Wilms Tumor, Type 1 Wilms Tumor, Somatic Adult Nephroblastoma Wt1 Disorder Renal Embryonic Tumor Adult Kidney Wilms Tumor Childhood Kidney Wilms Tumor Nonanaplastic Kidney Wilms Tumor
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-111558	Bobcat339	Inhibitor	99.44%	Unkown
HY-111558A	Bobcat339 hydrochloride	Inhibitor	99.62%	Unkown
HY-402410	TETi76	Inhibitor	97.49%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TET2	VGNC	VGNC:47261
Mus musculus	TET2	MGD	MGI:2443298
Felis catus	TET2	VGNC	VGNC:66093
Bos taurus	TET2	VGNC	VGNC:35757
Rattus norvegicus	TET2	RGD	RGD:1311625
Macaca mulatta	TET2	VGNC	VGNC:100278
Others	TET2	NCBI