SEMG1 - semenogelin 1 (the main protein of the human semen coagulum) Gene

Also Known as SGI; SEMG; CT103; dJ172H20.2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6406

About SEMG1

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:45,207,033-45,209,768 (from NCBI)

This gene has 1 transcript (splice variant), 29 orthologues and 1 paralogue. Low expression observed in reference dataset.

Summary

The protein encoded by this gene is the predominant protein in semen. The encoded secreted protein is involved in the formation of a gel matrix that encases ejaculated spermatozoa. This preproprotein is proteolytically processed by the prostate-specific antigen (PSA) protease to generate multiple peptide products that exhibit distinct functions. One of these peptides, SgI-29, is an antimicrobial peptide with Antibacterial activity. This proteolysis process also breaks down the gel matrix and allows the spermatozoa to move more freely. This gene and another similar semenogelin gene are present in a gene cluster on chromosome 20. [provided by RefSeq, Feb 2016]

SEMG1 Products (1)

mRNA	Protein	Name
NM_003007.5	NP_002998.1	semenogelin-1 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	8665956	GOA
enables zinc ion binding	IMP IMP: Inferred from mutant phenotype	15563730	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in antibacterial humoral response	IDA IDA: Inferred from direct assay	18714013	GOA
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: Inferred from direct assay	18314226	GOA
involved in coagulation	IDA IDA: Inferred from direct assay	8665956	GOA
involved in killing of cells of another organism	IDA IDA: Inferred from direct assay	18314226	GOA
involved in negative regulation of calcium ion import	IDA IDA: Inferred from direct assay	22075473	GOA
involved in negative regulation of flagellated sperm motility	IDA IDA: Inferred from direct assay	22075473	GOA
involved in negative regulation of flagellated sperm motility	IMP IMP: Inferred from mutant phenotype	19889947	GOA
involved in positive regulation of serine-type endopeptidase activity	IMP IMP: Inferred from mutant phenotype	15563730	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	2912989	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	17567961	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SEMG1 Protein Structure

Semenogelin

0
100
200
300
400
462 a.a.

Protein Preferred Names	Protein Names
semenogelin-1	SgI-29

SEMG1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SEMG1	P04279	COLGALT2	Homo sapiens	Q8IYK4	Anti Tag CoIP	33961781
Intra	SEMG1	P04279	COLGALT2	Homo sapiens	Q8IYK4	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SEMG1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71287	Semenogelin-1 Protein, Human (HEK293, His)	AAH07096.1 (Q24-T402)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Male Infertility	Infertility, Male Infertility Male Male Sterility Absolute Infertility
Pelvic Varices	Varix Of Pelvis Pelvic Varicose Vein
Infertility
Epididymis Disease
Spermatogenic Failure	Azoospermia Spgf Spermatogenic Failure, Susceptibility To Absent Sperm Aspermatogenesis Infertility Due To Azoospermia Hypospermatogenesis Azoospermatism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12669	SEMG1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21044	Semg1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27562	Semg1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SEMG1	RGD	RGD:3790
Others	SEMG1	NCBI