1. Epigenetics
  2. DNA Methyltransferase
  3. Bobcat339

Bobcat339 

Cat. No.: HY-111558
Handling Instructions

Bobcat339 is a potent and selective cytosine-based inhibitor of TET enzyme, with the IC50s of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription.

For research use only. We do not sell to patients.

Bobcat339 Chemical Structure

Bobcat339 Chemical Structure

CAS No. : 2280037-51-4

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Description

Bobcat339 is a potent and selective cytosine-based inhibitor of TET enzyme, with the IC50s of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription[1].

IC50 & Target

IC50: 33 μM (TET1); 73 μM (TET2)[1]

In Vitro

Bobcat339 (10 μM; 24 hours) significantly reduces global 5hmC levels by inhibiting TET enzyme function in HT-22 cells[1].

Molecular Weight

297.74

Formula

C₁₆H₁₂ClN₃O

CAS No.

2280037-51-4

SMILES

NC1=NC(N(C2=CC=CC(C3=CC=CC=C3)=C2)C=C1Cl)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Bobcat339Bobcat 339Bobcat-339DNA MethyltransferaseDNMTsDNA MTasesCytosine-based,TETenzymeTET1,TET2epigeneticsInhibitorinhibitorinhibit

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