2. Epigenetics
  3. DNA Methyltransferase
    TET Protein
  4. Bobcat339

Bobcat339 

Cat. No.: HY-111558
Handling Instructions

Bobcat339 is a potent and selective cytosine-based inhibitor of TET enzyme, with IC50s of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription.

For research use only. We do not sell to patients.

Bobcat339 Chemical Structure

Bobcat339 Chemical Structure

CAS No. : 2280037-51-4

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Top Publications Citing Use of Products

    Bobcat339 purchased from MCE. Usage Cited in: Aquaculture. 2023: 739234.

    Bobcat 339 (4 mM; every 48 h for a total of 7 injections) inject into the molluscum of the oyster utilizing a syringe, the expression levels of Sox-like and Sox8 are significantly increased, which are 1.93 and 1.47 times higher than the control group, respectively.

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    Description

    Bobcat339 is a potent and selective cytosine-based inhibitor of TET enzyme, with IC50s of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription[1].

    IC50 & Target[1]

    TET1

    33 μM (IC50)

    TET2

    73 μM (IC50)

    In Vitro

    Bobcat339 (10 μM; 24 hours) significantly reduces global 5hmC levels by inhibiting TET enzyme function in HT-22 cells[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    297.74

    Formula

    C16H12ClN3O
    CAS No.
    SMILES

    NC1=NC(N(C2=CC=CC(C3=CC=CC=C3)=C2)C=C1Cl)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Keywords:

    Bobcat3392280037-51-4Bobcat 339Bobcat-339DNA MethyltransferaseTET ProteinDNMTsDNA MTasesTET enzymeTen-eleven-translocation (TET) proteinTen-eleven translocation (TET) methylcytosine dioxygenaseCytosine-based,TETenzymeTET1,TET2epigeneticsInhibitorinhibitorinhibit

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