PHC3 - polyhomeotic homolog 3 Gene

Also Known as EDR3; HPH3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 80012

About PHC3

Cytogenetic location: 3q26.2 Genomic coordinates (GRCh38): 3:170,087,584-170,181,733 (from NCBI)

This gene has 17 transcripts (splice variants), 260 orthologues and 18 paralogues. Ubiquitous expression in bone marrow (RPKM 7.6), thyroid (RPKM 6.5) and 25 other tissues.

Summary

Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in negative regulation of transcription, DNA-templated. Located in nucleoplasm. Part of PRC1 complex. [provided by Alliance of Genome Resources, Apr 2022]

PHC3 Products (2)

mRNA	Protein	Name
NM_001308116.2	NP_001295045.1	polyhomeotic-like protein 3 isoform 2
NM_024947.4	NP_079223.3	polyhomeotic-like protein 3 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of PRC1 complex	IDA IDA: Inferred from direct assay	12167701	GOA
part of PcG protein complex	IDA IDA: Inferred from direct assay	21282530	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17001316	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PHC3 Protein Structure

SAM_1

0
200
400
600
800
983 a.a.

Protein Preferred Names	Protein Names
polyhomeotic-like protein 3	early development regulator 3

PHC3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PHC3	Q8NDX5	OGT	Homo sapiens	O15294	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Toxic Myocarditis
Hyperoxaluria, Primary, Type Iii	Primary Hyperoxaluria Type 3 HP3 Ph Iii Primary Hyperoxaluria Type Iii Hyperoxaluria Primary 3 Hyperoxaluria Non-Hp1/Non-Hp2 Hyperoxaluria Non-Ph I/Ph Ii Form Hyperoxaluria Primary Type Iii
Hyperoxaluria, Primary, Type Ii	Primary Hyperoxaluria Type 2 D-Glycerate Dehydrogenase Deficiency Glyoxylate Reductase/Hydroxypyruvate Reductase Deficiency HP2 Oxalosis Ii Glyceric Aciduria L-Glyceric Aciduria Primary Hyperoxaluria, Type Ii Oxalosis 2 Hyperoxaluria Primary 2 Hyperoxaluria Primary Type Ii Ph2 Primary Hyperoxaluria Type Ii
Laurence-Moon Syndrome	LNMS Laurence-Moon-Biedl Syndrome
Nephronophthisis 2	NPHP2 Nph2 Nephronophthisis 2, Infantile Infantile Nephronophthisis 2 Infantile Nephronophthisis Nephronophthisis, Type 2
Retinitis Pigmentosa 30	RP30 Retinitis Pigmentosa-30 Retinitis Pigmentosa, Type 30
46,Xy Sex Reversal 8	SRXY8 Male Pseudohermaphroditism Due To Deficiency Of Testicular 17,20-Desmolase Tdd 46,Xy Disorder Of Sex Development Due To Testicular 17,20-Desmolase Deficiency 46xy Sex Reversal 8 46xy Sex Reversal 8, Modifier Of Male Pseudohermaphroditism: Deficiency Of Testicular 17,20-Desmolase
Nephronophthisis 3	NPHP3 Nph3 Adolescent Nephronophthisis Nephronophthisis, Type 3
Methylmalonic Aciduria And Homocystinuria, Cblx Type	Mental Retardation, X-Linked 3 Methylmalonic Acidemia With Homocystinuria, Type Cblx MAHCX Intellectual Developmental Disorder, X-Linked 3 Xlid3 Mrx3 Methylmalonic Acidemia And Homocysteinemia Cblx Type Combined Defect In Adenosylcobalamin And Methylcobalamin Synthesis, Type Cblx Methylmalonic Aciduria With Homocystinuria, Type Cblx Methylmalonic Acidemia And Homocysteinemia, Cblx Type Methylmalonic Aciduria And Homocysteinemia, Cblx Type Methylmalonic Aciduria And Homocysteinemia , Cblx Type Mental Retardation, X-Linked, Type 3
Primary Autosomal Recessive Microcephaly	Autosomal Recessive Primary Microcephaly Mcph True Microcephaly Microcephalia Vera Microcephaly Vera Microcephaly Primary Hereditary Microcephaly, Primary, Autosomal Recessive Primary Microcephaly
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10411	PHC3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PHC3	VGNC	VGNC:64135
Rattus norvegicus	PHC3	RGD	RGD:1307998
Mus musculus	PHC3	MGD	MGI:2181434
Canis familiaris	PHC3	VGNC	VGNC:53462
Bos taurus	PHC3	VGNC	VGNC:50022
Macaca mulatta	PHC3	VGNC	VGNC:75804
Others	PHC3	NCBI