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Cat. No.: HY-184594

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WDR5 ligand 4

WDR5 ligand 4 is a WDR5 ligand. WDR5 ligand 4 can be used as a ligand for target protein for PROTAC in the synthesis of WDR5 PROTAC degraders. WDR5 ligand 4 can be coupled with the VHL ligand (S,R,S)-AHPC-Me (HY-112078) via linker to synthesize MS67 (HY-141796). WDR5 ligand 4 can be used in cancer research.

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CAS No.: 2407457-23-0
Formule: C₂₇H₂₇F₄N₅O₃
Masse moléculaire:545.53

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Please store the product under the recommended conditions in the Certificate of Analysis.

WDR5 ligand 4 Chemical Structure

CAS No.: 2407457-23-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

Chemical Information

CAS No. 2407457-23-0
Masse moléculaire 545.53
Formule C₂₇H₂₇F₄N₅O₃
SMILES

O=C(C(C(C(F)(F)F)=C1)=CNC1=O)NC2=C(N3C[C@H](N([C@H](C3)C)C)C)C=CC(C4=CC(C(N)=O)=CC=C4F)=C2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Xufen Yu, et al. A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models. Sci Transl Med. 2021 Sep 29;13(613):eabj1578. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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