HBI-2375
Based on 1 Customer Validation
HBI-2375 (HYBI-084) is a brain-penetrant WDR5 inhibitor with an IC50 of 4.48 nM. HBI-2375 binds to the WINR5 and disrupts MLL1-WDR5 protein-protein interactions. HBI-2375 inhibits cancer cells proliferation and shows anti-tumor activity in AML mouse models, and increases tumor CD8+ cytotoxic T lymphocyte infiltration. HBI-2375 inhibits hERG with an IC50 of 17 µM.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.06%
- CAS 番号: 2982574-79-6
- 分子式: C29H36ClF2N9O2
- 分子量:616.11
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
HBI-2375 inhibits the WDR5 WIN-site protein-protein interaction with an IC50 of 5 nM[1].
HBI-2375 reduces the viability of MV4:11 MLL-rearranged acute myeloid leukemia cells with a GI50 of 3200 nM[1].
HBI-2375 potently inhibits WDR5 in a cell-free biochemical assay with an IC50 of 4.48 nM[2].
HBI-2375 inhibits MV4-11 leukemia cell proliferation with an average IC50 of 3.17 µM in CTG assays[2].
HBI-2375 inhibits hERG in a cell-based assay with an IC50 of 17 µM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2982574-79-6
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性状 Solid
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分子量 616.11
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分子式 C29H36ClF2N9O2
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Color White to off-white
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SMILES
ClC1=C(C)C(F)=C(N)C=C1C(NC(C=C(N2C=C(C(N3CCN(C)CC3)=O)N=N2)C(F)=C4)=C4N5C[C@@H](C)N(C)[C@@H](C)C5)=O
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別名
HYBI-084
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 20 mg/mL (32.46 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (279 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6231 mL | 8.1154 mL | 16.2309 mL | 40.5772 mL |
| 5 mM | 0.3246 mL | 1.6231 mL | 3.2462 mL | 8.1154 mL | |
| 10 mM | 0.1623 mL | 0.8115 mL | 1.6231 mL | 4.0577 mL | |
| 15 mM | 0.1082 mL | 0.5410 mL | 1.0821 mL | 2.7051 mL | |
| 20 mM | 0.0812 mL | 0.4058 mL | 0.8115 mL | 2.0289 mL | |
| 25 mM | 0.0649 mL | 0.3246 mL | 0.6492 mL | 1.6231 mL | |
| 30 mM | 0.0541 mL | 0.2705 mL | 0.5410 mL | 1.3526 mL |
HBI-2375 関連分類
HY-175802 関連分類
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Keywords
- HBI-2375
- 2982574-79-6
- HYBI-084
- HBI2375
- HBI 2375
- HYBI084
- HYBI 084
- WDR5
- Potassium Channel
- WIN-site
- MLL1-WDR5 complex
- glioblastoma
- acute myeloid leukemia
- MLL1 histone methyl transferase
- MV4:11 MLL-rearranged acute myeloid leukemia cells
- CD8+ cytotoxic T lymphocyte
- H3K4 methylation
- AML mouse models
- Inhibitor
- inhibitor
- inhibit