ZBTB48 - zinc finger and BTB domain containing 48 Gene

Also Known as HKR3; TZAP; ZNF855; pp9964

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3104

About ZBTB48

Cytogenetic location: 1p36.31 Genomic coordinates (GRCh38): 1:6,579,994-6,589,280 (from NCBI)

This gene has 8 transcripts (splice variants), 200 orthologues and 36 paralogues. Ubiquitous expression in testis (RPKM 9.3), spleen (RPKM 7.4) and 25 other tissues.

Summary

Enables double-stranded telomeric DNA binding activity; identical protein binding activity; and transcription cis-regulatory region binding activity. Involved in positive regulation of transcription, DNA-templated and telomere maintenance via telomere lengthening. Located in chromosome, telomeric region. [provided by Alliance of Genome Resources, Apr 2022]

ZBTB48 Products (3)

mRNA Protein Name
NM_001278647.2 NP_001265576.1 telomere zinc finger-associated protein
NM_001278648.2 NP_001265577.1 telomere zinc finger-associated protein
NM_005341.4 NP_005332.1 telomere zinc finger-associated protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables double-stranded telomeric DNA binding IDA
IDA: Inferred from direct assay
28082411 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
28500257 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
28500257 GOA
involved in telomere maintenance via telomere lengthening IMP
IMP: Inferred from mutant phenotype
28082411 GOA
Cellular Component GO Annotation Evidence References Source
located in chromosome, telomeric region IDA
IDA: Inferred from direct assay
28082411 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZBTB48 Protein Structure

BTB

BTB: BTB/POZ domain (16 - 114)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (306 - 327)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (365 - 387)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (407 - 427)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (451 - 475)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (479 - 504)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (507 - 531)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (565 - 589)

  • 0
  • 200
  • 400
  • 600
  • 688 a.a.
Protein Preferred Names Protein Names

telomere zinc finger-associated protein

  • GLI-Kruppel family member HKR3

ZBTB48 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZBTB48 P10074 KRTAP10-5 Homo sapiens P60370
Y2H Prey Pooling
25416956
Intra
ZBTB48 P10074 KRTAP10-5 Homo sapiens P60370
Validated Y2H
25416956
Intra
ZBTB48 P10074 KRTAP10-7 Homo sapiens P60409
Validated Y2H
32296183
Intra
ZBTB48 P10074 KRTAP10-7 Homo sapiens P60409
Y2H Array
32296183
Intra
ZBTB48 P10074 KRTAP10-7 Homo sapiens P60409
Y2H Prey Pooling
32296183
Intra
ZBTB48 P10074 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra
ZBTB48 P10074 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra
ZBTB48 P10074 KRTAP1-1 Homo sapiens Q07627
Validated Y2H
32296183
Intra
ZBTB48 P10074 ZNF837 Homo sapiens Q96EG3
Validated Y2H
32296183
Intra
ZBTB48 P10074 ZNF837 Homo sapiens Q96EG3
Y2H Prey Pooling
32296183
Intra
ZBTB48 P10074 ZNF837 Homo sapiens Q96EG3
Y2H Array
32296183
Intra
ZBTB48 P10074 SPANXN2 Homo sapiens Q5MJ10
Validated Y2H
32296183
Intra
ZBTB48 P10074 ZNF317 Homo sapiens Q96PQ6
Y2H Array
32296183
Intra
ZBTB48 P10074 ZNF317 Homo sapiens Q96PQ6
Validated Y2H
32296183
Intra
ZBTB48 P10074 ZNF317 Homo sapiens Q96PQ6
Y2H Prey Pooling
32296183
Intra
ZBTB48 P10074 MCC Homo sapiens P23508
Y2H Prey Pooling
32296183
Intra
ZBTB48 P10074 MCC Homo sapiens P23508
Y2H Array
32296183
Intra
ZBTB48 P10074 MCC Homo sapiens P23508
Validated Y2H
32296183
Intra
ZBTB48 P10074 ZNF408 Homo sapiens Q9H9D4
Validated Y2H
32296183
Intra
ZBTB48 P10074 ZBTB26 Homo sapiens Q9HCK0
Validated Y2H
32296183
Intra
ZBTB48 P10074 ZBTB26 Homo sapiens Q9HCK0
Y2H Array
32296183
Intra
ZBTB48 P10074 ZBTB26 Homo sapiens Q9HCK0
Y2H Prey Pooling
32296183
Intra
ZBTB48 P10074 ZBTB9 Homo sapiens Q96C00
Y2H Prey Pooling
32296183
Intra
ZBTB48 P10074 ZBTB9 Homo sapiens Q96C00
Validated Y2H
32296183
Intra
ZBTB48 P10074 ZBTB9 Homo sapiens Q96C00
Y2H Array
32296183
Intra
ZBTB48 P10074 WDR5 Homo sapiens P61964
Validated Y2H
32296183
Intra
ZBTB48 P10074 GPATCH2L Homo sapiens Q9NWQ4
Y2H Prey Pooling
25416956
Intra
ZBTB48 P10074 GPATCH2L Homo sapiens Q9NWQ4
Y2H Array
25416956
Intra
ZBTB48 P10074 GPATCH2L Homo sapiens Q9NWQ4
Validated Y2H
25416956
Intra
ZBTB48 P10074 ZBTB6 Homo sapiens Q15916
Y2H Prey Pooling
32296183
Intra
ZBTB48 P10074 ZBTB6 Homo sapiens Q15916
Validated Y2H
32296183
Intra
ZBTB48 P10074 ZBTB6 Homo sapiens Q15916
Y2H Array
32296183
Intra
ZBTB48 P10074 TRIM41 Homo sapiens Q8WV44
Y2H Prey Pooling
32296183
Intra
ZBTB48 P10074 TRIM41 Homo sapiens Q8WV44
Y2H Array
32296183
Intra
ZBTB48 P10074 TRIM41 Homo sapiens Q8WV44
Y2H
21516116
Intra
ZBTB48 P10074 TRIM41 Homo sapiens Q8WV44
Validated Y2H
32296183
Intra
ZBTB48 P10074 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
32296183
Intra
ZBTB48 P10074 CEP70 Homo sapiens Q8NHQ1
Validated Y2H
32296183
Intra
ZBTB48 P10074 CEP70 Homo sapiens Q8NHQ1
Y2H Array
32296183
Intra
ZBTB48 P10074 DVL3 Homo sapiens Q92997
Y2H Prey Pooling
32296183
Intra
ZBTB48 P10074 DVL3 Homo sapiens Q92997
Validated Y2H
32296183
Intra
ZBTB48 P10074 DVL3 Homo sapiens Q92997
Y2H Array
32296183
Intra
ZBTB48 P10074 L3MBTL2 Homo sapiens Q969R5
Validated Y2H
32296183
Intra
ZBTB48 P10074 THAP1 Homo sapiens Q9NVV9
Validated Y2H
32296183
Intra
ZBTB48 P10074 THAP1 Homo sapiens Q9NVV9
Y2H Array
32296183
Intra
ZBTB48 P10074 ZBTB8A Homo sapiens Q96BR9
Y2H Array
32296183
Intra
ZBTB48 P10074 ZBTB8A Homo sapiens Q96BR9
Y2H Pooling
16189514
Intra
ZBTB48 P10074 ZBTB8A Homo sapiens Q96BR9
Validated Y2H
25416956
Intra
ZBTB48 P10074 ZBTB8A Homo sapiens Q96BR9
Y2H Prey Pooling
32296183
Intra
ZBTB48 P10074 ZBTB8A Homo sapiens Q96BR9
Validated Y2H
32296183
Intra
ZBTB48 P10074 ZBTB8A Homo sapiens Q96BR9
Y2H Array
25416956
Intra
ZBTB48 P10074 NME7 Homo sapiens Q9Y5B8
Validated Y2H
32296183
Intra
ZBTB48 P10074 NME7 Homo sapiens Q9Y5B8
Y2H Array
25416956
Intra
ZBTB48 P10074 NME7 Homo sapiens Q9Y5B8
Validated Y2H
25416956
Intra
ZBTB48 P10074 ZBTB48 Homo sapiens P10074
Y2H Array
32296183
Intra
ZBTB48 P10074 ZBTB48 Homo sapiens P10074
Validated Y2H
32296183
Intra
ZBTB48 P10074 ZBTB48 Homo sapiens P10074
Y2H Prey Pooling
32296183
Intra
ZBTB48 P10074 ZBTB48 Homo sapiens P10074
Y2H Array
25416956
Intra
ZBTB48 P10074 OPTN Homo sapiens Q96CV9
Validated Y2H
32814053
Intra
ZBTB48 P10074 OPTN Homo sapiens Q96CV9
Y2H Pooling
32814053
Intra
ZBTB48 P10074 OPTN Homo sapiens Q96CV9
Y2H Array
32814053
Intra
ZBTB48 P10074 TSPYL2 Homo sapiens Q9H2G4
Y2H Prey Pooling
32296183
Intra
ZBTB48 P10074 TSPYL2 Homo sapiens Q9H2G4
Validated Y2H
32296183
Intra
ZBTB48 P10074 TSPYL2 Homo sapiens Q9H2G4
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Neuroblastoma

  • Nb

  • Neuroblastoma, Susceptibility To

  • Neuroblastomas

  • Central Neuroblastoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15978 ZBTB48 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ZBTB48 VGNC VGNC:79959
Rattus norvegicus ZBTB48 RGD RGD:1311581
Bos taurus ZBTB48 VGNC VGNC:37085
Canis familiaris ZBTB48 VGNC VGNC:48540
Felis catus ZBTB48 VGNC VGNC:80407
Mus musculus ZBTB48 MGD MGI:2140248
Others ZBTB48 NCBI