TSPYL2 - TSPY like 2 Gene

Also Known as CDA1; CTCL; NP79; TSPX; CINAP; DENTT; SE204; HRIHFB2216

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64061

About TSPYL2

Cytogenetic location: Xp11.22 Genomic coordinates (GRCh38): X:53,082,367-53,088,540 (from NCBI)

This gene has 6 transcripts (splice variants), 224 orthologues and 18 paralogues. Broad expression in ovary (RPKM 45.2), testis (RPKM 42.8) and 24 other tissues.

Summary

This gene encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth. [provided by RefSeq, Sep 2009]

TSPYL2 Products (1)

mRNA Protein Name
NM_022117.4 NP_071400.1 testis-specific Y-encoded-like protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
26496610 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA replication IDA
IDA: Inferred from direct assay
11395479 GOA
involved in negative regulation of cell growth IDA
IDA: Inferred from direct assay
11395479 GOA
involved in regulation of protein kinase activity IDA
IDA: Inferred from direct assay
11395479 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleolus IDA
IDA: Inferred from direct assay
11395479 GOA
located in nucleus IDA
IDA: Inferred from direct assay
11395479 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TSPYL2 Protein Structure

NAP

NAP: Nucleosome assembly protein (NAP) (216 - 398)

  • 0
  • 200
  • 400
  • 600
  • 693 a.a.
Protein Preferred Names Protein Names

testis-specific Y-encoded-like protein 2

  • CASK-interacting nucleosome assembly protein

TSPYL2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TSPYL2 Q9H2G4 ZNF286A Homo sapiens Q9HBT8
Validated Y2H
32296183
Intra
TSPYL2 Q9H2G4 ZNF687 Homo sapiens Q8N1G0
Y2H Prey Pooling
32296183
Intra
TSPYL2 Q9H2G4 ZNF687 Homo sapiens Q8N1G0
Y2H Array
32296183
Intra
TSPYL2 Q9H2G4 H2BC15 Homo sapiens U3KQK0
Validated Y2H
32296183
Intra
TSPYL2 Q9H2G4 XAGE1A Homo sapiens Q9HD64
Validated Y2H
32296183
Intra
TSPYL2 Q9H2G4 ABT1 Homo sapiens Q9ULW3
Validated Y2H
32296183
Intra
TSPYL2 Q9H2G4 ZNF835 Homo sapiens Q9Y2P0
Validated Y2H
32296183
Intra
TSPYL2 Q9H2G4 NOL12 Homo sapiens Q9UGY1
Validated Y2H
32296183
Intra
TSPYL2 Q9H2G4 NOP53 Homo sapiens Q9NZM5
Validated Y2H
32296183
Intra
TSPYL2 Q9H2G4 HMGXB4 Homo sapiens Q9UGU5
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Gonadoblastoma

  • GBY
Pitt-Hopkins-Like Syndrome 2

  • PTHSL2

  • Mesh

  • D006985

  • Mesh

  • D008607
Syndromic X-Linked Intellectual Disability Najm Type

  • Mental Retardation And Microcephaly With Pontine And Cerebellar Hypoplasia

  • Micpch

  • X-Linked Intellectual Disability-Microcephaly-Pontocerebellar Hypoplasia Syndrome
Syndromic X-Linked Intellectual Disability Claes-Jensen Type

  • Mental Retardation, X-Linked, Syndromic, Claes-Jensen Type

  • Mrxscj

  • Mrxsj

  • Syndromic X-Linked Intellectual Disability Due To Jarid1c Mutation

  • Syndromic X-Linked Mental Retardation Jarid1c-Related
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15182 TSPYL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TSPYL2 VGNC VGNC:66640
Mus musculus TSPYL2 MGD MGI:106244
Canis familiaris TSPYL2 VGNC VGNC:47928
Bos taurus TSPYL2 VGNC VGNC:36445
Macaca mulatta TSPYL2 VGNC VGNC:79433
Rattus norvegicus TSPYL2 RGD RGD:1563283
Others TSPYL2 NCBI