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ABT1 - activator of basal transcription 1 Gene

Also Known as Esf2; hABT1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 29777

About ABT1

Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:26,596,953-26,600,739 (from NCBI)

This gene has 1 transcript (splice variant) and 194 orthologues. Ubiquitous expression in bone marrow (RPKM 4.4), lymph node (RPKM 3.9) and 25 other tissues.

Summary

Basal transcription of genes by RNA polymerase II requires the interaction of TATA-binding protein (TBP) with the core region of class II promoters. Studies in mouse suggest that the protein encoded by this gene likely activates basal transcription from class II promoters by interaction with TBP and the class II promoter DNA. [provided by RefSeq, Jul 2008]

ABT1 Products (1)

mRNA	Protein	Name
NM_013375.4	NP_037507.1	activator of basal transcription 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19299493	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
activator of basal transcription 1	TATA-binding protein-binding protein

ABT1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ABT1	Q9ULW3	CCDC136	Homo sapiens	Q96JN2-2	Y2H Array	25416956
Intra	ABT1	Q9ULW3	FAM9B	Homo sapiens	Q8IZU0	Validated Y2H	25416956
Intra	ABT1	Q9ULW3	FAM9B	Homo sapiens	Q8IZU0	Y2H Array	25416956
Intra	ABT1	Q9ULW3	RNF151	Homo sapiens	Q2KHN1	Y2H Prey Pooling	32296183
Intra	ABT1	Q9ULW3	RNF151	Homo sapiens	Q2KHN1	Y2H Array	32296183
Intra	ABT1	Q9ULW3	KANK2	Homo sapiens	Q63ZY3	Y2H Array	32296183
Intra	ABT1	Q9ULW3	KANK2	Homo sapiens	Q63ZY3	Y2H Prey Pooling	32296183
Intra	ABT1	Q9ULW3	EMD	Homo sapiens	P50402	Y2H Prey Pooling	32296183
Intra	ABT1	Q9ULW3	EMD	Homo sapiens	P50402	Y2H Array	25416956
Intra	ABT1	Q9ULW3	EMD	Homo sapiens	P50402	Y2H Array	32296183
Intra	ABT1	Q9ULW3	CDCA7L	Homo sapiens	Q96GN5	Y2H Prey Pooling	25416956
Intra	ABT1	Q9ULW3	SYNE4	Homo sapiens	Q8N205	Y2H Prey Pooling	25416956
Intra	ABT1	Q9ULW3	SYNE4	Homo sapiens	Q8N205	Validated Y2H	25416956
Intra	ABT1	Q9ULW3	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	32296183
Intra	ABT1	Q9ULW3	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	32296183
Intra	ABT1	Q9ULW3	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	25416956
Intra	ABT1	Q9ULW3	DVL3	Homo sapiens	Q92997	Y2H Prey Pooling	32296183
Intra	ABT1	Q9ULW3	DVL3	Homo sapiens	Q92997	Y2H Array	32296183
Intra	ABT1	Q9ULW3	LZTS2	Homo sapiens	Q9BRK4	Y2H Prey Pooling	25416956
Intra	ABT1	Q9ULW3	LZTS2	Homo sapiens	Q9BRK4	Validated Y2H	25416956
Intra	ABT1	Q9ULW3	LZTS2	Homo sapiens	Q9BRK4	Y2H Array	25416956
Intra	ABT1	Q9ULW3	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	ABT1	Q9ULW3	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	ABT1	Q9ULW3	TSPYL2	Homo sapiens	Q9H2G4	Anti Tag CoIP	33961781
Intra	ABT1	Q9ULW3	TSPYL2	Homo sapiens	Q9H2G4	Y2H Array	32296183
Intra	ABT1	Q9ULW3	TSPYL2	Homo sapiens	Q9H2G4	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Spinal Muscular Atrophy, Distal, Autosomal Recessive, 1	Smard1 DSMA1 Sianrf Dhmn6 Spinal Muscular Atrophy With Respiratory Distress 1 HMN6 Severe Infantile Axonal Neuropathy With Respiratory Failure Autosomal Recessive Distal Spinal Muscular Atrophy 1 Diaphragmatic Spinal Muscular Atrophy Spinal Muscular Atrophy With Respiratory Distress Type 1 Neuronopathy, Distal Hereditary Motor, Type Vi Hmn Vi Neuronopathy, Severe Infantile Axonal, With Respiratory Failure Distal Spinal Muscular Atrophy 1 Autosomal Recessive Spinal Muscular Atrophy With Respiratory Distress Distal Hereditary Motor Neuropathy Type 6 Distal-Hmn Type 6 Severe Infantile Axonal Neuropathy With Respiratory Failure Type 1 Spinal Muscular Atrophy, Diaphragmatic Distal Hereditary Motor Neuronopathy Type Vi Distal Spinal Muscular Atrophy Type 1 Hmnvi Spinal Muscular Atrophy With Respiratory Distress Autosomal Recessive Distal Spinal Muscular Atrophy Type 1 Neuronopathy, Distal Hereditary Motor, 6 Dhmn Vi Distal Hereditary Motor Neuropathy Type Vi Severe Infantile Axonal Neuronopathy With Respiratory Failure Spinal Muscular Atrophy Distal Autosomal Recessive 1 Atrophy, Muscular, Spinal, Distal, Type 1
Autosomal Recessive Distal Hereditary Motor Neuronopathy	Autosomal Recessive Distal Spinal Muscular Atrophy
Spinocerebellar Ataxia 17	Spinocerebellar Ataxia Type 17 SCA17 Huntington Disease-Like 4 Hdl4 Olivopontocerebellar Atrophy V Cerebelloparenchymal Disorder Ii Opca5 Cpd2 Sca 17 Ataxia, Spinocerebellar, Type 17
Acute Diarrhea
Essential Thrombocythemia	Essential Thrombocytosis Familial Thrombocytosis Hemorrhagic Thrombocythemia Hereditary Thrombocythemia Primary Thrombocytosis Idiopathic Thrombocythemia Primary Thrombocythemia Thrombocythemia, Essential Essential Thrombocythaemia Et Familial Thrombocythemia Thrombocythemia Essential
Autosomal Dominant Cerebellar Ataxia	Spinocerebellar Ataxia Adca Pierre Marie Cerebellar Ataxia Ataxia, Spinocerebellar Sca Autosomal Dominant Spinocerebellar Ataxia Spinocerebellar Ataxias

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00114	ABT1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ABT1	VGNC	VGNC:102372
Rattus norvegicus	ABT1	RGD	RGD:1310785
Mus musculus	ABT1	MGD	MGI:1353636
Bos taurus	ABT1	VGNC	VGNC:25514
Macaca mulatta	ABT1	VGNC	VGNC:69448
Canis familiaris	ABT1	VGNC	VGNC:37485
Others	ABT1	NCBI