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NOP53 - NOP53 ribosome biogenesis factor Gene

Also Known as PICT1; PICT-1; GLTSCR2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 29997

Summary

Enables 5S rRNA binding activity; identical protein binding activity; and p53 binding activity. Involved in several processes, including negative regulation of DNA-templated transcription; regulation of intracellular signal transduction; and regulation of protein metabolic process. Located in cytosol; nuclear lumen; and rDNA heterochromatin. [provided by Alliance of Genome Resources, Jun 2026]
Ubiquitous expression in ovary (RPKM 175.8), spleen (RPKM 136.0) and 25 other tissues.

NOP53 Products (1)

mRNA	Protein	Name
NM_015710.5	NP_056525.2	ribosome biogenesis protein NOP53

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 5S rRNA binding	IDA IDA: Inferred from direct assay	24120868	GOA
enables identical protein binding	IDA IDA: Inferred from direct assay	24735870	GOA
enables p53 binding	IPI IPI: Inferred from physical interaction	22522597	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15355975	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	27829214	GOA
involved in DNA repair	IMP IMP: Inferred from mutant phenotype	21741933	GOA
involved in cellular response to hypoxia	IMP IMP: Inferred from mutant phenotype	22522597	GOA
involved in mitotic G2 DNA damage checkpoint signaling	IMP IMP: Inferred from mutant phenotype	21741933	GOA
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	16971513	GOA
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	22522597	GOA
involved in negative regulation of protein-containing complex assembly	IMP IMP: Inferred from mutant phenotype	25956029	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	25956029	GOA
involved in negative regulation of transcription of nucleolar large rRNA by RNA polymerase I	IMP IMP: Inferred from mutant phenotype	27729611	GOA
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	25818168	GOA
involved in positive regulation of protein K63-linked deubiquitination	IMP IMP: Inferred from mutant phenotype	27824081	GOA
involved in protein localization to nucleoplasm	IMP IMP: Inferred from mutant phenotype	25818168	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	15355975	GOA
involved in regulation of RIG-I signaling pathway	IMP IMP: Inferred from mutant phenotype	27824081	GOA
involved in regulation of aerobic respiration	IMP IMP: Inferred from mutant phenotype	24556985	GOA
involved in regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	21167305	GOA
involved in regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	21167305	GOA
involved in regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	15355975	GOA
involved in regulation of signal transduction by p53 class mediator	IMP IMP: Inferred from mutant phenotype	22522597	GOA
involved in ribosomal large subunit assembly	IMP IMP: Inferred from mutant phenotype	24120868	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	24923447	GOA
located in fibrillar center	IDA IDA: Inferred from direct assay	27729611	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	20042497	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	22522597	GOA
colocalizes with rDNA heterochromatin	IDA IDA: Inferred from direct assay	27729611	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NOP53 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NOP53	Q9NZM5	CFTR	Homo sapiens	P13569	Ub Reconstruction	35156780
Intra	NOP53	Q9NZM5	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	32296183
Intra	NOP53	Q9NZM5	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	32296183
Intra	NOP53	Q9NZM5	TSPYL2	Homo sapiens	Q9H2G4	Y2H Prey Pooling	32296183
Intra	NOP53	Q9NZM5	TSPYL2	Homo sapiens	Q9H2G4	Anti Tag CoIP	33961781
Intra	NOP53	Q9NZM5	TSPYL2	Homo sapiens	Q9H2G4	Anti Tag CoIP	28514442
Intra	NOP53	Q9NZM5	TSPYL2	Homo sapiens	Q9H2G4	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09430	NOP56 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09431	NOP58 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22682	Nop56 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29196	Nop56 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown