CFTR - CF transmembrane conductance regulator Gene

Also Known as CF; MRP7; ABC35; ABCC7; CFTR/MRP; TNR-CFTR; dJ760C5.1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1080

About CFTR

Cytogenetic location: 7q31.2 Genomic coordinates (GRCh38): 7:117,480,025-117,668,665 (from NCBI)

This gene has 38 transcripts (splice variants), 215 orthologues, 11 paralogues and is associated with 10 phenotypes. Biased expression in gall bladder (RPKM 28.8), colon (RPKM 22.3) and 6 other tissues.

Summary

This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. The encoded protein functions as a Chloride Channel, making it unique among members of this protein family, and controls ion and water secretion and absorption in epithelial tissues. Channel activation is mediated by cycles of regulatory domain phosphorylation, ATP-binding by the nucleotide-binding domains, and ATP hydrolysis. Mutations in this gene cause cystic fibrosis, the most common lethal genetic disorder in populations of Northern European descent. The most frequently occurring mutation in cystic fibrosis, DeltaF508, results in impaired folding and trafficking of the encoded protein. Multiple pseudogenes have been identified in the human genome. [provided by RefSeq, Aug 2017]

CFTR Products (1)

mRNA	Protein	Name
NM_000492.4	NP_000483.3	cystic fibrosis transmembrane conductance regulator

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 14-3-3 protein binding	EXP EXP: Inferred from Experiment	26888287	GOA
enables 14-3-3 protein binding	IMP IMP: Inferred from mutant phenotype	26888287	GOA
enables 14-3-3 protein binding	IPI IPI: Inferred from physical interaction	26888287	GOA
enables ATP hydrolysis activity	IDA IDA: Inferred from direct assay	8910473	GOA
enables PDZ domain binding	IDA IDA: Inferred from direct assay	11707463	GOA
enables Sec61 translocon complex binding	IDA IDA: Inferred from direct assay	9792704	GOA
enables bicarbonate transmembrane transporter activity	IDA IDA: Inferred from direct assay	15010471	GOA
enables chloride channel activity	IDA IDA: Inferred from direct assay	11524016	GOA
enables chloride channel activity	IMP IMP: Inferred from mutant phenotype	19621064	GOA
enables chloride channel inhibitor activity	IDA IDA: Inferred from direct assay	22178883	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	19398555	GOA
enables intracellularly ATP-gated chloride channel activity	IMP IMP: Inferred from mutant phenotype	8910473	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9671706	GOA
enables protein-folding chaperone binding	IPI IPI: Inferred from physical interaction	16207813	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in bicarbonate transport	IDA IDA: Inferred from direct assay	15010471	GOA
involved in cellular response to forskolin	IDA IDA: Inferred from direct assay	15010471	GOA
involved in chloride transmembrane transport	IDA IDA: Inferred from direct assay	11524016	GOA
involved in chloride transmembrane transport	IMP IMP: Inferred from mutant phenotype	19621064	GOA
involved in multicellular organismal-level water homeostasis	IMP IMP: Inferred from mutant phenotype	19621064	GOA
involved in positive regulation of cyclic nucleotide-gated ion channel activity	IMP IMP: Inferred from mutant phenotype	24885604	GOA
involved in positive regulation of exocytosis	IMP IMP: Inferred from mutant phenotype	24885604	GOA
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IGI IGI: Inferred from genetic interaction	24885604	GOA
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	24885604	GOA
involved in positive regulation of voltage-gated chloride channel activity	IDA IDA: Inferred from direct assay	22006324	GOA
involved in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	21884936	GOA
involved in transepithelial water transport	IMP IMP: Inferred from mutant phenotype	19621064	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	12801959	GOA
located in apical plasma membrane	IMP IMP: Inferred from mutant phenotype	19621064	GOA
located in cell surface	IDA IDA: Inferred from direct assay	20658517	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	18570918	GOA
located in cytosol	IDA IDA: Inferred from direct assay	24885604	GOA
located in early endosome	IDA IDA: Inferred from direct assay	19398555	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	11707463	GOA
located in membrane	IDA IDA: Inferred from direct assay	8910473	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	11524016	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	11707463	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	17462998	GOA
located in recycling endosome	IDA IDA: Inferred from direct assay	18570918	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CFTR Protein Structure

ABC_membrane

ABC_tran

CFTR_R

ABC_membrane

ABC_tran

0
300
600
900
1200
1480 a.a.

Protein Preferred Names	Protein Names
cystic fibrosis transmembrane conductance regulator	cAMP-dependent chloride channel channel conductance-controlling ATPase cystic fibrosis transmembrane conductance regulating cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)

CFTR Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CFTR	P13569	BICDL2	Homo sapiens	A1A5D9	Ub Reconstruction	35156780
Intra	CFTR	P13569	SRP68	Homo sapiens	Q9UHB9	BioID	36012204
Intra	CFTR	P13569	SRP68	Homo sapiens	Q9UHB9	Ub Reconstruction	35156780
Intra	CFTR	P13569	COPG1	Homo sapiens	Q9Y678	BioID	36012204
Intra	CFTR	P13569	COPG1	Homo sapiens	Q9Y678	Pull Down	29924966
Intra	CFTR	P13569	COPG1	Homo sapiens	Q9Y678	Anti Bait CoIP	26618866
Intra	CFTR	P13569	COPG1	Homo sapiens	Q9Y678	Crosslink	31324722
Intra	CFTR	P13569	COPG1	Homo sapiens	Q9Y678	Ub Reconstruction	35156780
Intra	CFTR	P13569	SH3BP4	Homo sapiens	Q9P0V3	BioID	36012204
Intra	CFTR	P13569	YTHDF1	Homo sapiens	Q9BYJ9	BioID	36012204
Intra	CFTR	P13569	ETFA	Homo sapiens	P13804	Anti Bait CoIP	26618866
Intra	CFTR	P13569	ETFA	Homo sapiens	P13804	Ub Reconstruction	35156780
Intra	CFTR	P13569	ETFA	Homo sapiens	P13804	BioID	36012204
Intra	CFTR	P13569	DDRGK1	Homo sapiens	Q96HY6	BioID	36012204
Intra	CFTR	P13569	FASTKD2	Homo sapiens	Q9NYY8	BioID	36012204
Intra	CFTR	P13569	SDHA	Homo sapiens	P31040	Crosslink	31324722
Intra	CFTR	P13569	SDHA	Homo sapiens	P31040	Anti Bait CoIP	26618866
Intra	CFTR	P13569	SDHA	Homo sapiens	P31040	Pull Down	29924966
Intra	CFTR	P13569	VAPA	Homo sapiens	Q9P0L0	BioID	36012204
Intra	CFTR	P13569	VAPA	Homo sapiens	Q9P0L0	Anti Bait CoIP	26618866
Intra	CFTR	P13569	VAPA	Homo sapiens	Q9P0L0	Ub Reconstruction	35156780
Intra	CFTR	P13569	SLC33A1	Homo sapiens	O00400	BioID	36012204
Intra	CFTR	P13569	SLC33A1	Homo sapiens	O00400	Ub Reconstruction	35156780
Intra	CFTR	P13569	ERICH5	Homo sapiens	Q6P6B1	Ub Reconstruction	35156780
Intra	CFTR	P13569	ERICH5	Homo sapiens	Q6P6B1	Anti Tag CoIP	35156780
Intra	CFTR	P13569	NHERF2	Homo sapiens	Q15599	Anti Bait CoIP	17110338
Intra	CFTR	P13569	NHERF2	Homo sapiens	Q15599	Pull Down	16203867
Intra	CFTR	P13569	NHERF2	Homo sapiens	Q15599	BioID	36012204
Intra	CFTR	P13569	NHERF2	Homo sapiens	Q15599	Anti Bait CoIP	26618866
Intra	CFTR	P13569	NHERF2	Homo sapiens	Q15599	Crosslink	31324722
Intra	CFTR	P13569	NHERF2	Homo sapiens	Q15599	FPS	28360110
Intra	CFTR	P13569	ATP2A2	Homo sapiens	P16615-1	Anti Bait CoIP	25661196
Intra	CFTR	P13569	ATP2A2	Homo sapiens	P16615-1	PLA	25661196
Intra	CFTR	P13569	VPS4A	Homo sapiens	Q9UN37	Anti Bait CoIP	17110338
Intra	CFTR	P13569	VPS4A	Homo sapiens	Q9UN37	BioID	36012204
Intra	CFTR	P13569	VPS4A	Homo sapiens	Q9UN37	Anti Bait CoIP	26618866
Intra	CFTR	P13569	VPS4A	Homo sapiens	Q9UN37	Ub Reconstruction	35156780
Intra	CFTR	P13569	VPS4A	Homo sapiens	Q9UN37	Crosslink	31324722
Intra	CFTR	P13569	VAPB	Homo sapiens	O95292	BioID	36012204
Intra	CFTR	P13569	VAPB	Homo sapiens	O95292	Anti Bait CoIP	26618866
Intra	CFTR	P13569	DHX30	Homo sapiens	Q7L2E3	BioID	36012204
Intra	CFTR	P13569	CASK	Homo sapiens	O14936	BioID	36012204
Intra	CFTR	P13569	ACOT8	Homo sapiens	O14734	Ub Reconstruction	35156780
Intra	CFTR	P13569	ABRAXAS1	Homo sapiens	Q6UWZ7	BioID	36012204
Intra	CFTR	P13569	ABRAXAS1	Homo sapiens	Q6UWZ7	Ub Reconstruction	35156780
Intra	CFTR	P13569	CYB561D1	Homo sapiens	Q8N8Q1	Ub Reconstruction	35156780
Intra	CFTR	P13569	MYADM	Homo sapiens	Q96S97	Crosslink	31324722
Intra	CFTR	P13569	MYADM	Homo sapiens	Q96S97	Ub Reconstruction	35156780
Intra	CFTR	P13569	GSTT2B	Homo sapiens	P0CG30	Ub Reconstruction	35156780
Intra	CFTR	P13569	GSTT2B	Homo sapiens	P0CG30	Anti Tag CoIP	35156780
Intra	CFTR	P13569	TRAFD1	Homo sapiens	O14545	BioID	36012204
Intra	CFTR	P13569	TRAFD1	Homo sapiens	O14545	Anti Tag CoIP	35156780
Intra	CFTR	P13569	TRAFD1	Homo sapiens	O14545	Anti Bait CoIP	26618866
Intra	CFTR	P13569	TRAFD1	Homo sapiens	O14545	Ub Reconstruction	35156780
Intra	CFTR	P13569	CAPN1	Homo sapiens	P07384	BioID	36012204
Intra	CFTR	P13569	CAPN1	Homo sapiens	P07384	Crosslink	31324722
Intra	CFTR	P13569	CAPN1	Homo sapiens	P07384	Anti Tag CoIP	31324722
Intra	CFTR	P13569	USP26	Homo sapiens	Q9BXU7	Ub Reconstruction	35156780
Intra	CFTR	P13569	USP26	Homo sapiens	Q9BXU7	Anti Tag CoIP	35156780
Intra	CFTR	P13569	SLC26A8	Homo sapiens	Q96RN1	Anti Bait CoIP	22121115
Intra	CFTR	P13569	ZNF22	Homo sapiens	P17026	Anti Tag CoIP	35156780
Intra	CFTR	P13569	CSHL1	Homo sapiens	Q14406	Ub Reconstruction	35156780
Intra	CFTR	P13569	FGL2	Homo sapiens	Q14314	Ub Reconstruction	35156780
Intra	CFTR	P13569	FGL2	Homo sapiens	Q14314	Anti Tag CoIP	35156780
Intra	CFTR	P13569	CHST14	Homo sapiens	Q8NCH0	Ub Reconstruction	35156780
Intra	CFTR	P13569	MCCC2	Homo sapiens	Q9HCC0	BioID	36012204
Intra	CFTR	P13569	MRPS27	Homo sapiens	Q92552	BioID	36012204
Intra	CFTR	P13569	AHCYL1	Homo sapiens	O43865	BioID	36012204
Intra	CFTR	P13569	AHCYL1	Homo sapiens	O43865	Ub Reconstruction	35156780
Intra	CFTR	P13569	PRAF2	Homo sapiens	O60831	Ub Reconstruction	35156780
Intra	CFTR	P13569	PRAF2	Homo sapiens	O60831	Anti Tag CoIP	35156780
Intra	CFTR	P13569	KLHL18	Homo sapiens	O94889	Ub Reconstruction	35156780
Intra	CFTR	P13569	USP10	Homo sapiens	Q14694	BioID	36012204
Intra	CFTR	P13569	USP10	Homo sapiens	Q14694	Ub Reconstruction	35156780
Intra	CFTR	P13569	USP10	Homo sapiens	Q14694	Anti Bait CoIP	21455491
Intra	CFTR	P13569	USP19	Homo sapiens	O94966	BioID	36012204
Intra	CFTR	P13569	CLCN3	Homo sapiens	P51790-2	Pull Down	12471024
Intra	CFTR	P13569	HMMR	Homo sapiens	O75330	BioID	36012204
Intra	CFTR	P13569	HMMR	Homo sapiens	O75330	Ub Reconstruction	35156780
Intra	CFTR	P13569	CCDC9	Homo sapiens	Q9Y3X0	Ub Reconstruction	35156780
Intra	CFTR	P13569	CCDC9	Homo sapiens	Q9Y3X0	Anti Tag CoIP	35156780
Intra	CFTR	P13569	FAAP100	Homo sapiens	Q0VG06	Ub Reconstruction	35156780
Intra	CFTR	P13569	PTCD1	Homo sapiens	O75127	BioID	36012204
Intra	CFTR	P13569	PTCD1	Homo sapiens	O75127	Ub Reconstruction	35156780
Intra	CFTR	P13569	TMEM237	Homo sapiens	Q96Q45	Ub Reconstruction	35156780
Intra	CFTR	P13569	TMEM237	Homo sapiens	Q96Q45	BioID	36012204
Intra	CFTR	P13569	DNAJB14	Homo sapiens	Q8TBM8	Ub Reconstruction	35156780
Intra	CFTR	P13569	DNAJB14	Homo sapiens	Q8TBM8	Anti Bait CoIP	26618866
Intra	CFTR	P13569	CAP1	Homo sapiens	Q01518	Pull Down	29924966
Intra	CFTR	P13569	CAP1	Homo sapiens	Q01518	Ub Reconstruction	35156780
Intra	CFTR	P13569	CAP1	Homo sapiens	Q01518	BioID	36012204
Intra	CFTR	P13569	CAP1	Homo sapiens	Q01518	Anti Bait CoIP	26618866
Intra	CFTR	P13569	ST6GALNAC1	Homo sapiens	Q9NSC7	Ub Reconstruction	35156780
Intra	CFTR	P13569	ST6GALNAC1	Homo sapiens	Q9NSC7	Anti Tag CoIP	35156780
Intra	CFTR	P13569	ARFGAP3	Homo sapiens	Q9NP61	BioID	36012204
Intra	CFTR	P13569	ARFGAP3	Homo sapiens	Q9NP61	Ub Reconstruction	35156780
Intra	CFTR	P13569	ALKBH7	Homo sapiens	Q9BT30	Ub Reconstruction	35156780
Intra	CFTR	P13569	KCNN4	Homo sapiens	O15554	Anti Bait CoIP	27092946
Intra	CFTR	P13569	KCNN4	Homo sapiens	O15554	FCS	27092946
Intra	CFTR	P13569	KCNN4	Homo sapiens	O15554	Lambda Y2H	27092946
Intra	CFTR	P13569	KCNN4	Homo sapiens	O15554	Confocal	27092946
Intra	CFTR	P13569	ALDOC	Homo sapiens	P09972	Pull Down	29924966
Intra	CFTR	P13569	ALDOC	Homo sapiens	P09972	Ub Reconstruction	35156780
Intra	CFTR	P13569	ALDOC	Homo sapiens	P09972	BioID	36012204
Intra	CFTR	P13569	DNAJC1	Homo sapiens	Q96KC8	Ub Reconstruction	35156780
Intra	CFTR	P13569	DNAJC1	Homo sapiens	Q96KC8	BioID	36012204
Intra	CFTR	P13569	KRT8	Homo sapiens	P05787	Anti Bait CoIP	22038833
Intra	CFTR	P13569	KRT8	Homo sapiens	P05787	PLA	22038833
Intra	CFTR	P13569	KRT8	Homo sapiens	P05787	Confocal	22038833
Intra	CFTR	P13569	KRT8	Homo sapiens	P05787	BioID	36012204
Intra	CFTR	P13569	CLIC1	Homo sapiens	O00299	BioID	36012204
Intra	CFTR	P13569	CLIC1	Homo sapiens	O00299	Anti Bait CoIP	26618866
Intra	CFTR	P13569	CLIC1	Homo sapiens	O00299	Crosslink	31324722
Intra	CFTR	P13569	CLIC1	Homo sapiens	O00299	Ub Reconstruction	35156780
Intra	CFTR	P13569	CLIC1	Homo sapiens	O00299	Pull Down	29924966
Intra	CFTR	P13569	DDX20	Homo sapiens	Q9UHI6	BioID	36012204
Intra	CFTR	P13569	RNF5	Homo sapiens	Q99942	IF	16901789
Intra	CFTR	P13569	RNF5	Homo sapiens	Q99942	BioID	36012204
Intra	CFTR	P13569	RNF5	Homo sapiens	Q99942	Anti Tag CoIP	16901789
Intra	CFTR	P13569	RNF5	Homo sapiens	Q99942	Anti Bait CoIP	26618866
Intra	CFTR	P13569	NHERF1	Homo sapiens	O14745	Anti Tag CoIP	31324722
Intra	CFTR	P13569	NHERF1	Homo sapiens	O14745	BioID	36012204
Intra	CFTR	P13569	NHERF1	Homo sapiens	O14745	Anti Bait CoIP	26618866
Intra	CFTR	P13569	NHERF1	Homo sapiens	O14745	Crosslink	31324722
Intra	CFTR	P13569	NHERF1	Homo sapiens	O14745	FPS	28360110
Intra	CFTR	P13569	NHERF1	Homo sapiens	O14745	Anti Bait CoIP	17110338
Intra	CFTR	P13569	PDZK1	Homo sapiens	Q5T2W1	Anti Bait CoIP	11051556
Intra	CFTR	P13569	PDZK1	Homo sapiens	Q5T2W1	Pull Down	12471024
Intra	CFTR	P13569	GOPC	Homo sapiens	Q9HD26	Confocal	28360110
Intra	CFTR	P13569	GOPC	Homo sapiens	Q9HD26	Crosslink	31324722
Intra	CFTR	P13569	GOPC	Homo sapiens	Q9HD26	BioID	36012204
Intra	CFTR	P13569	PTBP1	Homo sapiens	P26599	Crosslink	31324722
Intra	CFTR	P13569	PTBP1	Homo sapiens	P26599	Pull Down	29924966
Intra	CFTR	P13569	PTBP1	Homo sapiens	P26599	BioID	36012204
Intra	CFTR	P13569	HSPD1	Homo sapiens	P10809	Anti Bait CoIP	17110338
Intra	CFTR	P13569	HSPD1	Homo sapiens	P10809	BioID	36012204
Intra	CFTR	P13569	HSPD1	Homo sapiens	P10809	Anti Bait CoIP	26618866
Intra	CFTR	P13569	HSPD1	Homo sapiens	P10809	Pull Down	29924966
Intra	CFTR	P13569	HSPD1	Homo sapiens	P10809	Ub Reconstruction	35156780
Intra	CFTR	P13569	CAPZB	Homo sapiens	P47756	Pull Down	29924966
Intra	CFTR	P13569	CAPZB	Homo sapiens	P47756	Anti Bait CoIP	26618866
Intra	CFTR	P13569	CAPZB	Homo sapiens	P47756	Ub Reconstruction	35156780
Intra	CFTR	P13569	CAPZB	Homo sapiens	P47756	BioID	36012204
Intra	CFTR	P13569	ACTB	Homo sapiens	P60709	Anti Bait CoIP	25712891
Intra	CFTR	P13569	ACTB	Homo sapiens	P60709	BioID	36012204
Intra	CFTR	P13569	ACTB	Homo sapiens	P60709	Anti Bait CoIP	22038833
Intra	CFTR	P13569	ACTB	Homo sapiens	P60709	Pull Down	29924966
Intra	CFTR	P13569	VDAC2	Homo sapiens	P45880	Anti Bait CoIP	26618866
Intra	CFTR	P13569	VDAC2	Homo sapiens	P45880	BioID	36012204
Intra	CFTR	P13569	VDAC2	Homo sapiens	P45880	Ub Reconstruction	35156780
Intra	CFTR	P13569	LGALS3BP	Homo sapiens	Q08380	Pull Down	29924966
Intra	CFTR	P13569	LGALS3BP	Homo sapiens	Q08380	Anti Bait CoIP	26618866
Intra	CFTR	P13569	LGALS3BP	Homo sapiens	Q08380	Confocal	26618866
Intra	CFTR	P13569	CANX	Homo sapiens	P27824	Anti Bait CoIP	26618866
Intra	CFTR	P13569	CANX	Homo sapiens	P27824	BioID	36012204
Intra	CFTR	P13569	CANX	Homo sapiens	P27824	Crosslink	31324722
Intra	CFTR	P13569	CANX	Homo sapiens	P27824	Anti Bait CoIP	17110338
Intra	CFTR	P13569	CANX	Homo sapiens	P27824	Anti Bait CoIP	16546175
Intra	CFTR	P13569	CANX	Homo sapiens	P27824	Pull Down	29924966
Intra	CFTR	P13569	GNB2	Homo sapiens	P62879	Pull Down	29924966
Intra	CFTR	P13569	GNB2	Homo sapiens	P62879	BioID	36012204
Intra	CFTR	P13569	GNB2	Homo sapiens	P62879	Crosslink	31324722
Intra	CFTR	P13569	GNB2	Homo sapiens	P62879	Ub Reconstruction	35156780
Intra	CFTR	P13569	TFG	Homo sapiens	Q92734	Anti Tag CoIP	35156780
Intra	CFTR	P13569	TFG	Homo sapiens	Q92734	Anti Bait CoIP	17110338
Intra	CFTR	P13569	TFG	Homo sapiens	Q92734	BioID	36012204
Intra	CFTR	P13569	TFG	Homo sapiens	Q92734	Ub Reconstruction	35156780
Intra	CFTR	P13569	STAU1	Homo sapiens	O95793	Ub Reconstruction	35156780
Intra	CFTR	P13569	STAU1	Homo sapiens	O95793	BioID	36012204
Intra	CFTR	P13569	STAU1	Homo sapiens	O95793	Anti Bait CoIP	26618866
Intra	CFTR	P13569	STAU1	Homo sapiens	O95793	Crosslink	31324722
Intra	CFTR	P13569	HACD3	Homo sapiens	Q9P035	Pull Down	29924966
Intra	CFTR	P13569	HACD3	Homo sapiens	Q9P035	Anti Bait CoIP	26618866
Intra	CFTR	P13569	HACD3	Homo sapiens	Q9P035	BioID	36012204
Intra	CFTR	P13569	HACD3	Homo sapiens	Q9P035	Crosslink	31324722
Intra	CFTR	P13569	HACD3	Homo sapiens	Q9P035	Confocal	26618866
Intra	CFTR	P13569	PSMD4	Homo sapiens	P55036	Anti Bait CoIP	26618866
Intra	CFTR	P13569	PSMD4	Homo sapiens	P55036	BioID	36012204
Intra	CFTR	P13569	CUL1	Homo sapiens	Q13616	BioID	36012204
Intra	CFTR	P13569	DARS2	Homo sapiens	Q6PI48	BioID	36012204
Intra	CFTR	P13569	DARS2	Homo sapiens	Q6PI48	Ub Reconstruction	35156780
Intra	CFTR	P13569	DERL1	Homo sapiens	Q9BUN8	Anti Bait CoIP	26618866
Intra	CFTR	P13569	DERL1	Homo sapiens	Q9BUN8	Anti Bait CoIP	16901789
Intra	CFTR	P13569	DERL1	Homo sapiens	Q9BUN8	BioID	36012204
Intra	CFTR	P13569	TMEM40	Homo sapiens	Q8WWA1	Ub Reconstruction	35156780
Intra	CFTR	P13569	TMEM40	Homo sapiens	Q8WWA1	Anti Tag CoIP	35156780
Intra	CFTR	P13569	TMEM40	Homo sapiens	Q8WWA1	Anti Bait CoIP	26618866
Intra	CFTR	P13569	SAXO4	Homo sapiens	Q7Z5V6	Anti Tag CoIP	35156780
Intra	CFTR	P13569	SAXO4	Homo sapiens	Q7Z5V6	Ub Reconstruction	35156780
Intra	CFTR	P13569	GGA1	Homo sapiens	Q9UJY5	BioID	36012204
Intra	CFTR	P13569	GGA1	Homo sapiens	Q9UJY5	Ub Reconstruction	35156780
Intra	CFTR	P13569	CALU	Homo sapiens	O43852-1	Anti Bait CoIP	22768251
Intra	CFTR	P13569	CALU	Homo sapiens	O43852-1	Pull Down	22768251
Intra	CFTR	P13569	KPNA5	Homo sapiens	O15131	Anti Bait CoIP	26618866
Intra	CFTR	P13569	EPHX1	Homo sapiens	P07099	BioID	36012204
Intra	CFTR	P13569	EPHX1	Homo sapiens	P07099	Ub Reconstruction	35156780
Intra	CFTR	P13569	STK26	Homo sapiens	Q9P289	BioID	36012204
Intra	CFTR	P13569	XAGE3	Homo sapiens	Q8WTP9	Anti Tag CoIP	35156780
Intra	CFTR	P13569	XAGE3	Homo sapiens	Q8WTP9	Ub Reconstruction	35156780
Intra	CFTR	P13569	CREB3L1	Homo sapiens	Q96BA8	Ub Reconstruction	35156780
Intra	CFTR	P13569	FHL2	Homo sapiens	Q14192	Ub Reconstruction	35156780
Intra	CFTR	P13569	FHL2	Homo sapiens	Q14192	Anti Bait CoIP	26618866
Intra	CFTR	P13569	FHL2	Homo sapiens	Q14192	Crosslink	31324722
Intra	CFTR	P13569	UNC119	Homo sapiens	Q13432	Ub Reconstruction	35156780
Intra	CFTR	P13569	SNRPN	Homo sapiens	P63162	BioID	36012204
Intra	CFTR	P13569	SNRPN	Homo sapiens	P63162	Ub Reconstruction	35156780
Intra	CFTR	P13569	HK1	Homo sapiens	P19367	BioID	36012204
Intra	CFTR	P13569	C8orf33	Homo sapiens	Q9H7E9	BioID	36012204
Intra	CFTR	P13569	C8orf33	Homo sapiens	Q9H7E9	Ub Reconstruction	35156780
Intra	CFTR	P13569	PDHA1	Homo sapiens	P08559	Ub Reconstruction	35156780
Intra	CFTR	P13569	PDHA1	Homo sapiens	P08559	BioID	36012204
Intra	CFTR	P13569	MELTF	Homo sapiens	P08582	Pull Down	29924966
Intra	CFTR	P13569	MELTF	Homo sapiens	P08582	Ub Reconstruction	35156780
Intra	CFTR	P13569	DRG1	Homo sapiens	Q9Y295	Crosslink	31324722
Intra	CFTR	P13569	DRG1	Homo sapiens	Q9Y295	BioID	36012204
Intra	CFTR	P13569	NOP53	Homo sapiens	Q9NZM5	Anti Bait CoIP	26618866
Intra	CFTR	P13569	GPX1	Homo sapiens	P07203	BioID	36012204
Intra	CFTR	P13569	GPX1	Homo sapiens	P07203	Ub Reconstruction	35156780
Intra	CFTR	P13569	PBDC1	Homo sapiens	Q9BVG4	Ub Reconstruction	35156780
Intra	CFTR	P13569	VTI1B	Homo sapiens	Q9UEU0	BioID	36012204
Intra	CFTR	P13569	VTI1B	Homo sapiens	Q9UEU0	Ub Reconstruction	35156780
Intra	CFTR	P13569	VTI1B	Homo sapiens	Q9UEU0	Anti Tag CoIP	35156780
Intra	CFTR	P13569	CRABP1	Homo sapiens	P29762	Ub Reconstruction	35156780
Intra	CFTR	P13569	CRABP1	Homo sapiens	P29762	Anti Tag CoIP	35156780
Intra	CFTR	P13569	GORASP2	Homo sapiens	Q9H8Y8	BioID	36012204
Intra	CFTR	P13569	GORASP2	Homo sapiens	Q9H8Y8	Anti Tag CoIP	21884936
Intra	CFTR	P13569	DDX19A	Homo sapiens	Q9NUU7	Anti Tag CoIP	35156780
Intra	CFTR	P13569	DDX19A	Homo sapiens	Q9NUU7	BioID	36012204
Intra	CFTR	P13569	DDX19A	Homo sapiens	Q9NUU7	Ub Reconstruction	35156780
Intra	CFTR	P13569	TRIM32	Homo sapiens	Q13049	Anti Bait CoIP	26618866
Intra	CFTR	P13569	TRIM32	Homo sapiens	Q13049	Ub Reconstruction	35156780
Intra	CFTR	P13569	ACCS	Homo sapiens	Q96QU6	Ub Reconstruction	35156780
Intra	CFTR	P13569	WWP2	Homo sapiens	O00308	Ub Reconstruction	35156780
Intra	CFTR	P13569	FKBP6	Homo sapiens	O75344	Ub Reconstruction	35156780
Intra	CFTR	P13569	DSTN	Homo sapiens	P60981	Pull Down	29924966
Intra	CFTR	P13569	DSTN	Homo sapiens	P60981	Crosslink	31324722
Intra	CFTR	P13569	DSTN	Homo sapiens	P60981	Anti Bait CoIP	26618866
Intra	CFTR	P13569	DSTN	Homo sapiens	P60981	Ub Reconstruction	35156780
Intra	CFTR	P13569	COASY	Homo sapiens	Q13057	BioID	36012204
Intra	CFTR	P13569	COASY	Homo sapiens	Q13057	Ub Reconstruction	35156780
Intra	CFTR	P13569	NAA10	Homo sapiens	P41227	BioID	36012204
Intra	CFTR	P13569	NAA10	Homo sapiens	P41227	Ub Reconstruction	35156780
Intra	CFTR	P13569	CEP55	Homo sapiens	Q53EZ4	BioID	36012204
Intra	CFTR	P13569	CEP55	Homo sapiens	Q53EZ4	Ub Reconstruction	35156780
Intra	CFTR	P13569	AKR7A3	Homo sapiens	O95154	Anti Tag CoIP	35156780
Intra	CFTR	P13569	AKR7A3	Homo sapiens	O95154	Ub Reconstruction	35156780
Intra	CFTR	P13569	LPAR2	Homo sapiens	Q9HBW0	Anti Bait CoIP	16203867
Intra	CFTR	P13569	BCAP31	Homo sapiens	P51572	IF	18555783
Intra	CFTR	P13569	BCAP31	Homo sapiens	P51572	Anti Bait CoIP	18555783
Intra	CFTR	P13569	BCAP31	Homo sapiens	P51572	BioID	36012204
Intra	CFTR	P13569	EDF1	Homo sapiens	O60869	BioID	36012204
Intra	CFTR	P13569	EDF1	Homo sapiens	O60869	Ub Reconstruction	35156780
Intra	CFTR	P13569	SHC1	Homo sapiens	P29353	Ub Reconstruction	35156780
Intra	CFTR	P13569	SHC1	Homo sapiens	P29353	BioID	36012204
Intra	CFTR	P13569	TRIM21	Homo sapiens	P19474	Crosslink	31324722
Intra	CFTR	P13569	TRIM21	Homo sapiens	P19474	Anti Bait CoIP	26618866
Intra	CFTR	P13569	TRIM21	Homo sapiens	P19474	Pull Down	29924966
Intra	CFTR	P13569	TRIM21	Homo sapiens	P19474	Confocal	26618866
Intra	CFTR	P13569	HINT2	Homo sapiens	Q9BX68	Ub Reconstruction	35156780
Intra	CFTR	P13569	LSP1	Homo sapiens	P33241	Ub Reconstruction	35156780
Intra	CFTR	P13569	TRIM5	Homo sapiens	Q9C035	Anti Bait CoIP	26618866
Intra	CFTR	P13569	TRIM5	Homo sapiens	Q9C035	Ub Reconstruction	35156780
Intra	CFTR	P13569	RBM14	Homo sapiens	Q96PK6	Pull Down	29924966
Intra	CFTR	P13569	RBM14	Homo sapiens	Q96PK6	BioID	36012204
Intra	CFTR	P13569	RBM14	Homo sapiens	Q96PK6	Ub Reconstruction	35156780
Intra	CFTR	P13569	SCAMP1	Homo sapiens	O15126	BioID	36012204
Intra	CFTR	P13569	SCAMP1	Homo sapiens	O15126	Ub Reconstruction	35156780
Intra	CFTR	P13569	PDIA3	Homo sapiens	P30101	Ub Reconstruction	35156780
Intra	CFTR	P13569	PDIA3	Homo sapiens	P30101	Anti Bait CoIP	26618866
Intra	CFTR	P13569	PDIA3	Homo sapiens	P30101	Crosslink	31324722
Intra	CFTR	P13569	PDIA3	Homo sapiens	P30101	BioID	36012204
Cross	CFTR	P13569	Shank2	Rattus norvegicus	Q9QX74	SPR	17244609

Cross: Cross-species interaction Intra: Intraspecies interaction

CFTR Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83773	CFTR Antibody(YA3569)	WB, IHC-P, IP, IF-Tissue	Human

Related Diseases

Diseases	Alias
Bilirubin Metabolic Disorder	Hyperbilirubinemia Hereditary Hyperbilirubinemia Hyperbilirubinemia, Hereditary Hyperbilirubinaemia
Hyperchlorhidrosis, Isolated	Isolated Hyperchlorhidrosis HYCHL Carbonic Anhydrase Xii Deficiency
Bronchiectasis 3
Polycystic Kidney Disease 1 With Or Without Polycystic Liver Disease	Polycystic Kidney Disease 1 PKD1 Adpkd Polycystic Kidney Disease, Adult, Type I Apkd1 Potter Type Iii Polycystic Kidney Disease Polycystic Kidney Disease, Adult Potter Type Iii Polycystic Kidney Disease, Formerly Polycystic Kidney Disease, Type 1 Adpkd1 Adult Polycystic Kidney Disease Type 1 Autosomal Dominant Polycystic Kidney Disease 1 Pkd-1 Polycystic Kidney Disease Adult Polycystic Kidney Disease Type I Polycystic Kidneys Polycystic Kidney Disease, Adult Type I Polycystic Kidney Type 1 Autosomal Dominant Disease Kidney Disease, Polycystic, Type 1 Polycystic Kidney, Autosomal Dominant Polycystic Kidney, Type 1 Autosomal Dominant Disease Polycystic Kidney Diseases
Bacterial Infectious Disease	Bacterial Infections Bacterial Infection Nos Disease Caused By Bacteria Bacterial Disease Or Disorder
Alpha-1-Antitrypsin Deficiency	Alpha 1-Antitrypsin Deficiency Alpha-1 Antitrypsin Deficiency Aat Deficiency Aatd A1ATD Emphysema Due To Aat Deficiency A1at Deficiency Hemorrhagic Diathesis Due To Antithrombin Pittsburgh Emphysema-Cirrhosis, Due To Aat Deficiency Alpha-1 Antiprotease Deficiency Alpha 1 Antitrypsin Deficiency Aat Alpha-1 Protease Inhibitor Deficiency Alpha-1 Related Emphysema Genetic Emphysema Hereditary Pulmonary Emphysema Inherited Emphysema Alpha-1-Proteinase Inhibitor Deficiency Alpha1-Antitrypsin Deficiency Alpha-1-Antitrypsin Deficiency, Autosomal Recessive Emphysema, Hereditary Pulmonary Aatd - [Alpha-1-Antitrypsin] Deficiency
Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease	Autosomal Recessive Polycystic Kidney Disease Arpkd Polycystic Kidney Disease, Autosomal Recessive Polycystic Kidney And Hepatic Disease 1 Pkhd1 PKD4 Polycystic Kidney Disease 4 With Or Without Hepatic Disease Polycystic Kidney Disease, Infantile, Type I Polycystic Kidney Disease, Infantile Type Polycystic Kidney, Autosomal Recessive Pkd3, Formerly Polycystic Kidney Disease 4, With Or Without Hepatic Disease Arpkd/Chf Ar-Pkd Polycystic Kidney Disease 4, With Or Without Polycystic Liver Disease Infantile Polycystic Kidney Disease Type I Pkd3 Kidney, Polycystic, Disease, Type 4, With/Without Hepatic Disease Polycystic Kidney Disease 3, Autosomal Dominant
Young Syndrome	Sinusitis-Infertility Syndrome Azoospermia-Sinopulmonary Infections Syndrome Azoospermia, Obstructive, And Chronic Sinopulmonary Infections Barry-Perkins-Young Syndrome Azoospermia Obstructive And Chronic Sinopulmonary Infections Barry Perkins Young Syndrome Azoospermia - Sinopulmonary Infections
Spermatogenic Failure 10	SPGF10 Spermatogenic Failure With Defective Sperm Annulus Spermatogenic Failure, Type 10
Pulmonary Disease, Chronic Obstructive	Chronic Obstructive Pulmonary Disease COPD Pulmonary Disease, Chronic Obstructive, Severe Early-Onset Chronic Obstructive Lung Disease Chronic Obstructive Airway Disease Pulmonary Disease, Chronic Obstructive, Susceptibility To Cold Severe Early-Onset Chronic Obstructive Pulmonary Disease Pulmonary Disease Chronic Obstructive Pulmonary Disease, Obstructive, Chronic, Susceptibility To Chronic Obstructive Pulmonary Disease Of Horses Common Cold Upper Respiratory Infections Copd - [Chronic Obstructive Pulmonary Disease] Coad - [Chronic Obstructive Airways Disease] Cold - [Chronic Obstructive Lung Disease] Chronic Airway Disease Nos Chronic Airways Limitation, Unspecified Chronic Obstructed Airway, Unspecified Chronic Obstructive Airway Disease, Unspecified Chronic Obstructive Airway, Unspecified Obstructive Lung Disease Nos Chronic Obstructive Lung Disease Nos Chronic Obstructive Lung Nos Obstructive Pulmonary Disease Nos Exacerbation Copd Nos Acute Exacerbation Copd
Hereditary Breast Ovarian Cancer Syndrome	Hereditary Breast And Ovarian Cancer Syndrome Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer Breast And/Or Ovarian Cancer Breast And Ovarian Cancer Syndrome Hboc Syndrome Hereditary Breast And Ovarian Cancer Brca1- Brca2-Associated Hboc
Primary Biliary Cholangitis	Primary Biliary Cirrhosis Biliary Liver Cirrhosis Chronic Nonsuppurative Destructive Cholangitis Familial Primary Biliary Cirrhosis Pbc Hanot Syndrome Cholestatic Cirrhosis Biliary Cirrhosis Primary Liver Cirrhosis, Biliary Hanot'S Cirrhosis Biliary Cirrhosis Pericholangiolic Biliary Cirrhosis Tannhauser-Magendantz Syndrome Hanot-Rossle Syndrome Hypertrophic Cirrhosis Todd Cirrhosis Hanot Cirrhosis Charcot Cirrhosis Mahon-Tannhauser Syndrome Toxic Cirrhosis Hypertrophic Biliary Cirrhosis Monolobular Cirrhosis Unilobar Cirrhosis Xanthomatous Biliary Cirrhosis
Hyperuricemia, Pulmonary Hypertension, Renal Failure, And Alkalosis Syndrome	Hupra Syndrome Alkalosis HUPRAS Hyperuricemia, Pulmonary Hypertension, Renal Failure, And Alkalosis Hyperuricemia, Pulmonary Hypertension, Renal Failure, Alkalosis Syndrome Hyperuricemia-Pulmonary Hypertension-Renal Failure-Alkalosis Syndrome Alkalosis Nos
Acute Necrotizing Pancreatitis	Acute Pancreatitis Pancreatitis, Acute Necrotizing Pancreatitis Necrotizing Necrotizing Pancreatitis Pancreatitis Pancreatitis Nos Acute Pancreas Inflammation
Pseudoxanthoma Elasticum	PXE Gronblad-Strandberg Syndrome Pseudoxanthoma Elasticum, Modifier Of Severity Of Gronblad-Strandberg-Touraine Syndrome Gronblad Strandberg Syndrome Groenblad-Strandberg Syndrome Nevus Elasticus Pxe - [Pseudoxanthoma Elasticum]
Cystic Kidney Disease	Renal Cyst Simple Renal Cyst Kidney Cysts Kidney Diseases, Cystic Renal Cysts Kidney Cyst Cystic Kidney Congenital Cystic Kidney Disease Cystic Kidney Diseases Bosniak 1 Cyst
Vas Deferens, Congenital Bilateral Aplasia Of	Congenital Bilateral Absence Of Vas Deferens CBAVD Cavd Congenital Bilateral Aplasia Of Vas Deferens Congenital Bilateral Absence Of The Vas Deferens Congenital Bilateral Agenesis Of Vas Deferens Absence Of Vas Deferens Absent Vasa Congenital Absence Of Vas Deferens Congenital Aplasia Of Vas Deferens Absent Vas Deferens Vas Deferens, Congenital Bilateral Absence
Chylomicron Retention Disease	CMRD Anderson Disease Lipid Transport Defect Of Intestine Hypobetalipoproteinemia With Accumulation Of Apolipoprotein B-Like Protein In Intestinal Cells Andd Anderson Syndrome Crd Andersons Disease Malabsorption Syndrome
Protein-Energy Malnutrition	PEM Protein Energy Malnutrition
Bronchitis	Chronic Bronchitis Acute Bronchitis Bronchitis, Chronic Acute Bronchitis And Bronchiolitis Chest Cold Chest Infection Ci - Chest Infection Recurrent Wheezy Bronchitis Bronchitis Chronic Lower Respiratory Tract Infection Acute Lower Respiratory Tract Infection Chronic Bronchitis Nos Senile Bronchitis Bronchitis Nos In Those Under L5 Years Of Age Bronchitis Nos
Hemochromatosis, Type 1	Hemochromatosis Hemochromatosis Type 1 Hereditary Hemochromatosis Hh HFE1 Hfe Hemochromatosis, Modifier Of Symptomatic Form Of Classic Hemochromatosis Symptomatic Form Of Hemochromatosis Type 1 Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis Haemochromatosis Iron Storage Disorder Bronze Diabetes Hlah Hfe Hemochromatosis, Hereditary Diabetes Bronze Classic Hemochromatosis Hfe-Associated Hereditary Hemochromatosis Hemochromatosis Classic Bronzed Cirrhosis Familial Hemochromatosis Genetic Hemochromatosis Hc Hereditary Haemochromatosis Pigmentary Cirrhosis Primary Hemochromatosis Troisier-Hanot-Chauffard Syndrome Von Recklenhausen-Applebaum Disease Hemochromatosis 1 Primary Hereditary Hemochromatosis Bronze Cirrhosis
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Autosomal Dominant Polycystic Kidney Disease	Polycystic Kidney Disease, Adult Type Adpkd Polycystic Kidney Diseases Polycystic Kidney, Autosomal Dominant Congenital Biliary Ectasias Polycystic Kidney And Hepatic Disease 1 Polycystic Kidney Disease, Autosomal Dominant Kidney, Polycystic, Disease, Autosomal Dominant Adult Polycystic Kidney Disease Polycystic Kidney, Adult Type Apckd - [Autosomal Polycystic Kidney Disease]
Sickle Cell Anemia	Hemoglobin Sc Disease Anemia, Sickle Cell Hbsc Disease Sickle Cell-Hemoglobin C Disease Syndrome Hb Ss Disease Sickle Cell Trait Drepanocytosis Haemoglobin Sc Disease Hb Sc Disease Hb-S/Hb-C Disease Hb-Ss Disease Without Crisis Hemoglobin S Disease Without Crisis Sickle Cell Anaemia Sickle-Cell/Hb-C Disease Without Crisis Sickle Cell - Hemoglobin C Disease Hbs Disease Hemoglobin S Disease Sickling Disorder Due To Hemoglobin S SKCA Sickle Cell Disease Sickle Cell-Hemoglobin C Disease Sickle-Cell Disease Carrier Sickle-Cell Heterozygous Disorder Haemoglobin A-S Genotype Hb-S - [Sickle Cell Haemoglobin] Carrier Sickle Cell Haemoglobin Trait As - [Sickle Cell Trait] Hbas - [Sickle Cell Haemoglobin Trait] Sickle-Cell Trait Haemoglobin Disease Haemoglobin Sickle Cell Trait Disorder Heterozygous Sickle Cell Trait Hbas - [Heterozygous Haemoglobin S]
Intestinal Pseudo-Obstruction	Chronic Intestinal Pseudoobstruction Chronic Intestinal Pseudo-Obstruction Cipo Neuronal Intestinal Dysplasia Hollow Visceral Myopathy Familial Visceral Neuropathy Paralytic Ileus Intestinal Pseudoobstruction Chronic Idiopathic Intestinal Pseudo-Obstruction Ciip Congenital Short Bowel Syndrome Enteric Neuropathy Familial Visceral Myopathy Ipo Pseudo-Obstruction Of Intestine Pseudointestinal Obstruction Syndrome Pseudoobstructive Syndrome Congenital Idiopathic Intestinal Pseudoobstruction Visceral Myopathy, Familial
Dubin-Johnson Syndrome	DJS Chronic Idiopathic Jaundice Jaundice, Chronic Idiopathic Hyperbilirubinemia, Dubin-Johnson Type Hyperbilirubinemia Ii Hyperbilirubinemia Type 2 Conjugated Hyperbilirubinemia Dubin-Sprinz Disease Sprinz-Nelson Syndrome Hblrdj Dubin Johnson Syndrome Hyperbilirubinemia 2 Black Liver-Jaundice Syndrome Chronic Idiopathic Jaundice With Pigmented Liver Dubin-Sprinz Syndrome Hyperbilirubinaemia Type 2 Djs - [Dubin-Johnson Syndrome]
Polycystic Kidney Disease	Polycystic Kidney Diseases Pkd Polycystic Renal Disease Kidney Disease, Polycystic Polycystic Kidney, Autosomal Dominant
Nephrogenic Diabetes Insipidus	Vasopressin-Resistant Diabetes Insipidus Diabetes Insipidus, Nephrogenic Diabetes Insipidus Nephrogenic Congenital Nephrogenic Diabetes Insipidus Adh Resistant Diabetes Insipidus Diabetes Insipidus Nephrogenic X-Linked Diabetes Insipidus Nephrogenic Type 1 Adh-Resistant Diabetes Insipidus Diabetes Insipidus Renalis Ndi Renal Diabetes Insipidus Familial Nephrogenic Diabetes Antidiuretic-Hormone-Resistant Diabetes Insipidus Adiuretin-Resistant Diabetes Insipidus Ndi - [Nephrogenic Diabetes Insipidus] Diabetes Tenuifluus Adh - [Antidiuretic-Hormone] Resistant Diabetes Insipidus Hereditary Nephrogenic Diabetes Insipidus Familial Nephrogenic Diabetes Insipidus Primary Nephrogenic Diabetes Insipidus
Pancreatitis	Mumps Pancreatitis
Intussusception	Intussusception Of Intestine Invagination Of Intestine Or Colon
Progressive Familial Intrahepatic Cholestasis	Abcb4-Related Intrahepatic Cholestasis Cholestasis, Progressive Familial Intrahepatic Pfic Byler Disease Abcb11-Related Intrahepatic Cholestasis Atp8b1-Related Intrahepatic Cholestasis Bsep Deficiency Byler Disease Byler Syndrome Fic1 Deficiency Low Γ-Gt Familial Intrahepatic Cholestasis Mdr3 Deficiency Pfic Cholestasis, Intrahepatic, Familial, Progressive Pfic - [Progressive Familial Intrahepatic Cholestasis]
Aspergillosis	Aspergillosis, Susceptibility To Infection Due To Aspergillus Aspergilloma Aspergillus Nodule Simple Aspergilloma Aspergillus Aspergillus Flavus Infection Aspergillus Fumigatus Infection Aspergillus Infection Infection By Aspergillus Fumigatus Intracavitary Aspergillus Fungus Ball Aspergillus Terreus
Secretory Diarrhea
Acrokeratoderma, Hereditary Papulotranslucent	Hereditary Papulotranslucent Acrokeratoderma
Methylmalonic Aciduria And Homocystinuria, Cbld Type	Homocystinuria, Cbld Type, Variant 1 Methylmalonic Aciduria And Homocystinuria Type Cbld Vitamin B12-Responsive Methylmalonic Acidemia, Type Cbldv2 MAHCD Methylmalonic Acidemia And Homocystinuria, Cbld Type Methylmalonic Aciduria, Cblh Type, Formerly Methylmalonic Acidemia, Cblh Type, Formerly Methylmalonic Aciduria, Cbld Type, Variant 2 Cobalamin D Deficiency Methylcobalamin Deficiency Type Cbldv1 Functional Methionine Synthase Deficiency Type Cbldv1 Vitamin B12-Responsive Methylmalonic Aciduria, Type Cbldv2 Methylmalonic Acidemia With Homocystinuria, Type Cbld Cbld Defect Cobalamin D Defect Combined Defect In Adenosylcobalamin And Methylcobalamin Synthesis, Type Cbld Methylmalonic Aciduria With Homocystinuria, Type Cbld Homocystinuria Cbld Variant 1 Methylmalonic Acidemia And Homocystinuria Cbld Type Methylmalonic Aciduria And Homocystinuria Cbld-Combined Methylmalonic Aciduria And Homocystinuria Cbld Original Methylmalonic Aciduria Cbld Variant 2 Aciduria, Methylmalonic, And Homocystinuria, Cbld Type
Microvillus Inclusion Disease	Congenital Microvillous Atrophy Intractable Diarrhea Of Infancy Congenital Familial Protracted Diarrhea With Enterocyte Brush-Border Abnormalities Davidson Disease Congenital Microvillus Atrophy Microvillous Inclusion Disease Mvid Diarrhea 2 With Microvillus Atrophy Mvd Congenital Familial Protracted Diarrhea Davidson'S Disease Familial Enteropathy, Microvillus Microvillus Atrophy, Congenital Congenital Enteropathy Familial Protracted Enteropathy Microvillous Atrophy Microvillus Atrophy With Diarrhea 2 Idi
Constipation
Cholangitis	Acute Cholangiolitis Ascending Cholangitis Cholangiolitis Cholangitis Nos Chronic Cholangiolitis Hepatic Duct Inflammation Acute Cholangitis Bile Duct Inflammation
Cholestasis, Benign Recurrent Intrahepatic, 1	Benign Recurrent Intrahepatic Cholestasis BRIC1 Summerskill Syndrome Bric Summerskill-Walshe-Tygstrup Syndrome Cholestasis, Benign Recurrent Intrahepatic Benign Recurrent Intrahepatic Cholestasis 1 Benign Recurrent Intrahepatic Cholestasis Type 1 Bric Type 1 Low Gamma-Gt Familial Intrahepatic Cholestasis Recurrent Familial Intrahepatic Cholestasis Cholestasis, Benign Recurrent Intrahepatic 1 Mild Atp8b1 Deficiency Recurrent Familial Intrahepatic Cholestasis 1 Abcb11-Related Intrahepatic Cholestasis Atp8b1-Related Intrahepatic Cholestasis Cholestasis, Intrahepatic, Recurrent, Benign, Type 1 Progressive Intrahepatic Cholestasis Cholestasis, Progressive Familial Intrahepatic 3 Bric - [Benign Recurrent Intrahepatic Cholestasis]
Alcoholic Pancreatitis	Pancreatitis, Alcoholic Pancreatitis Alcoholic
Urea Cycle Disorder	Urea Cycle Disorders Urea Cycle Disorders, Inborn Disorder Of Metabolism Of Ornithine, Citrulline, Argininosuccinic Acid, Arginine And Ammonia Disorder Of Urea Cycle Metabolism Urea Cycle Defect Ucd Disorder Of The Urea Cycle Metabolism Disorder Of Urea Cycle Disorders Of Metabolism Of Ornithine, Citrulline, Argininosuccinic Acid, Arginine And Ammonia Ammonia Metabolic Disorder
Cholangitis, Primary Sclerosing	Primary Sclerosing Cholangitis PSC Sclerosing Cholangitis Cholangitis, Sclerosing Cholangitis Primary Sclerosing Psc - [Primary Sclerosing Cholangitis]
Gallbladder Disease	Gallbladder Diseases Gall Bladder Gall Bladder Diseases Abnormal Gallbladder Function
Cryptorchidism, Unilateral Or Bilateral	Cryptorchidism Undescended Testicle Undescended Testis Cryptorchism Undescended Testicles CRYPTO Impaired Testicular Descent Cryptosporidiosis Retained Testis Unilateral Cryptorchidism Unilateral Undescended Testis Nondescent Unilateral Testicle Unilateral Cryptorchism Ectopic Testis, Unilateral Bilateral Cryptorchidism Bilateral Cryptorchism Bilateral Nondescent Testicle Bilateral Undescended Testes Bilateral Ectopic Testes
Hypogonadotropic Hypogonadism	Klinefelter Syndrome Klinefelter'S Syndrome Xxy Syndrome Xxy Trisomy Hypogonadotropism 47, Xxy Congenital Idiopathic Hypogonadotropic Hypogonadism Isolated Congenital Gonadotropin Deficiency 47,Xxy Syndrome 47, Xxy Syndrome Klinefelters Syndrome Hypogonadism Klinefelter Syndrome In Males Klinefelter Syndrome, Unspecified Klinefelter Syndrome Karyotype 47, Xxy
Male Infertility With Azoospermia Or Oligozoospermia Due To Single Gene Mutation
Leber Plus Disease	Leber Congenital Amaurosis Lca Leber'S Amaurosis Leber'S Disease Amaurosis Congenita Of Leber Amaurosis Congenita Of Leber, Type 1 Lhon Plus Disease Congenital Absence Of The Rods And Cones Congenital Retinal Blindness Crb Congenital Amaurosis Of Retinal Origin Leber'S Congenital Amaurosis Leber Congenital Amaurosis 1 Leber'S Congenital Tapetoretinal Degeneration Leber'S Congenital Tapetoretinal Dysplasia Lca1 Leber Congenital Amaurosis Type 1 Retinal Blindness, Congenital Amaurosis, Leber Congenital Dysgenesis Neuroepithelialis Retinae Hereditary Epithelial Dysplasia Of Retina Hereditary Retinal Aplasia Heredoretinopathia Congenitalis Leber Abiotrophy Leber Congenital Tapetoretinal Degeneration Lebers Congenital Amaurosis Optic Atrophy, Hereditary, Leber
Pancreatic Cancer	Pancreatic Carcinoma Familial Pancreatic Carcinoma Pancreatic Neoplasm Carcinoma Of Pancreas Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Cancer Of The Pancreas Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Oligospermia
Idiopathic Bronchiectasis
Plasma Protein Metabolism Disease
Autosomal Genetic Disease	Autosomal Hereditary Disorder
Polycystic Liver Disease	Autosomal Dominant Polycystic Liver Disease Isolated Polycystic Liver Disease Pcld Congenital Cystic Liver Disease Congenital Hepatic Cyst Fibrocystic Liver Disease Isolated Autosomal Dominant Polycystic Liver Disease Adpcld Liver Disease, Polycystic Multiple Cysts Of Liver Pld - [Polycystic Liver Disease] Polycystic Liver Disorder Polycystic Liver Congenital Polycystic Disease Of Liver Congenital Polycystic Liver Disease
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Autosomal Recessive Disease	Autosomal Recessive Disorder
Male Infertility	Infertility, Male Infertility Male Male Sterility Absolute Infertility
Renal Hypodysplasia/Aplasia 1	Renal Agenesis Renal Adysplasia Renal Aplasia RHDA1 Hereditary Renal Aplasia Hra Hereditary Urogenital Adysplasia Hypodysplasia/Aplasia, Renal, Type 1 Congenital Absence Of Kidneys Syndrome Congenital Absence Of Kidney Aplastic Kidney
Spermatogenic Failure	Azoospermia Spgf Spermatogenic Failure, Susceptibility To Absent Sperm Aspermatogenesis Infertility Due To Azoospermia Hypospermatogenesis Azoospermatism
Typhoid Fever	Typhoid Enteric Fever Typhoidal Salmonellosis Ileotyphus Infection By Salmonella Typhi Typhoid Any Site Typhoid Fever Any Site Typhoid Infection Typhoid Infection Any Site Typhoid Fever Confirmed Enteric Fever Nos
Pancreatitis, Hereditary	Hereditary Pancreatitis Chronic Pancreatitis Hereditary Chronic Pancreatitis Hp Pancreatitis, Chronic, Susceptibility To PCTT Hpc Pancreatitis, Chronic Pancreatitis, Chronic, Protection Against Autosomal Dominant Hereditary Pancreatitis Familial Pancreatitis Cp Pancreatitis Hereditary
Allergic Bronchopulmonary Aspergillosis	Aspergillosis, Allergic Bronchopulmonary Abpa Allergic Bronchopulmonary Mycosis Hinson-Pepys Disease Pulmonary Aspergillus Disease Allergic Aspergillosis Aspergillosis Allergic Bronchopulmonary
Spermatocele
Autoimmune Pancreatitis	Lymphoplasmocytic Sclerosing Pancreatitis Aip
Exocrine Pancreatic Insufficiency
Bronchiectasis	Polynesian Bronchiectasis Kartagener Syndrome Bronchiectasis Nos
Hypokalemia	Potassium Deficiency Potassium Deficiency Disorder Hypopotassemia Potassium Potassium [K] Deficiency Hypokalaemic Syndrome Hypopotassaemia Hypopotassaemia Syndrome Hypokalaemic Potassium Depletion
Paranasal Sinus Disease	Paranasal Sinus Diseases Disorder Of Nasal Sinus
Pseudohypoaldosteronism
Muscular Dystrophy	Muscular Dystrophies Congenital Md Congenital Muscular Dystrophy Cmd Mdc Dystrophy, Muscular Gower'S Muscular Dystrophy Progressive Musclular Dystrophy Pseudohypertrophic Atrophy Pseudohypertrophic Muscle Paralysis Pseudohypertrophic Muscular Atrophy Pseudohypertrophic Muscular Dystrophy Pseudohypertrophic Paralysis Pseudomuscular Hypertrophy
Lung Disease	Lung Diseases Disorder Of Lung Abnormality Of The Lung
Nuchal Bleb, Familial	Fetal Cystic Hygroma Cystic Hygroma, Fetal Fch Lymphangioma, Cystic
Phenylketonuria	Phenylalanine Hydroxylase Deficiency PKU Pah Deficiency Folling Disease Maternal Phenylketonuria Phenylketonurias Oligophrenia Phenylpyruvica Hyperphenylalaninemia, Non-Pku Mild Folling'S Disease Phenylalaninemia Mild Phenylketonuria Mild Pku Variant Pku Variant Phenylketonuria Mpku Phenylketonuria, Maternal Deficiency Disease, Phenylalanine Hydroxylase Phenylalanine Hydroxylase Deficiency Disease Hyperphenylalaninemic Embryopathy Maternal Pku Maternal Hyperphenylalaninemia Phenylketonuric Embryopathy Hyperphenylalaninemia HPA Non-Phenylketonuria Hyperphenylalaninemia NON-PKU HPA Phenylketonuria Maternal Classical Phenylketonuria Hyperphenylalaninaemia Pku - [Phenylketonuria]
Tuberculous Epididymitis	Tuberculosis Of Epididymis
Kartagener Syndrome	Kartagener'S Syndrome
Chronic Ethmoiditis	Chronic Ethmoidal Sinusitis Chronic Ethmoid Sinusitis Ethmoidal Sinusitis - Chronic
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Aquagenic Syringeal Acrokeratoderma	Aquagenic Palmoplantar Keratoderma Aquagenic Keratoderma Aquagenic Wrinkling Of The Palms Transient Reactive Papulotranslucent Acrokeratoderma Aquagenic Wrinkling Of The Hands
Pancreas Disease	Abnormality Of The Pancreas Pancreatic Diseases
Biliary Dyskinesia	Sphincter Of Oddi Dysfunction
Primary Ciliary Dyskinesia	Immotile Cilia Syndrome Kartagener Syndrome Dextrocardia Bronchiectasis And Sinusitis Pcd Ciliary Motility Disorders Ciliary Motility Disorder Immotile Ciliary Syndrome Ciliary Dyskinesia Primary Ics Polynesian Bronchiectasis Dextrocardia-Bronchiectasis-Sinusitis Syndrome Immotile Cilia Syndrome, Kartagener Type Primary Ciliary Dyskinesia And Situs Inversus Primary Ciliary Dyskinesia, Kartagener Type Siewert Syndrome Dyskinesia, Ciliary, Primary
Mucopolysaccharidosis-Plus Syndrome	Mucopolysaccharidosis Mucopolysaccharidosis-Like Syndrome With Congenital Heart Defects And Hematopoietic Disorders MPSPS Mucopolysaccharidoses Mps Mucopolysaccharidosis-Like Plus Disease Disorders Of Glycosaminoglycan Metabolism
Inflammatory Diarrhea
Pseudohypoaldosteronism, Type I, Autosomal Recessive	Autosomal Recessive Pseudohypoaldosteronism Type 1 PHA1B Pseudohypoaldosteronism Type 1 Pseudohypoaldosteronism, Type I Generalized Pha1 Generalized Pseudohypoaldosteronism Type 1 Pseudohypoaldosteronism Type 1 Autosomal Recessive Pha1 Pseudohypoaldosteronism Pha I, Autosomal Recessive Autosomal Recessive Pha 1 Pseudohypoaldosteronism Type 1, Recessive Pseudohypoaldosteronism Type I Autosomal Recessive Pha1 Pha Type 1 Pseudohypoaldosteronism 1, Autosomal Recessive Multisystem Pseudohypoaldosteronism Pha Type I, Autosomal Recessive Pseudohypoaldosteronism Type I, Autosomal Recessive
Tay-Sachs Disease	Hexosaminidase A Deficiency TSD Hexa Deficiency Gm2 Gangliosidosis, Type 1 Hexosaminidase Alpha-Subunit Deficiency Gm2-Gangliosidosis, Several Forms Gm2-Gangliosidosis, B, B1, Ab Variant B Variant Gm2 Gangliosidosis Sphingolipidosis, Tay-Sachs Gm2-Gangliosidosis, Type I B Variant Gm2-Gangliosidosis Hex A Pseudodeficiency Hexa Disorders Beta-Hexosaminidase A Deficiency Gm2 Gangliosidosis, Type I Gangliosidosis Gm2 , Type 1 Gm2 Gangliosidosis, B, B1 Variant Gm2-Gangliosidosis 1 GM2G1 Gm2-Gangliosidosis B Variant Tay-Sachs Disease Pseudo-Ab Variant Tay-Sachs Disease Variant B1 Gangliosidoses, Gm2
Ileus	Ileus Of Intestine
Duodenal Atresia	Duodenal Stenosis Familial Duodenal Atresia
Bronchiectasis With Or Without Elevated Sweat Chloride 1	Bronchiectasis With Or Without Elevated Sweat Chloride 1, Modifier Of BESC1 Cystic Fibrosis-Like Syndrome Bronchiectasis, With/Without Elevated Sweat Chloride, Type 1, Modifier Of
Cholera	Vibrio Cholerae Infection Cholera - Vibrio Cholerae Cholera Due To Vibrio Cholerae Vibrio Cholerae Cholera Syndrome Asiatic Cholera Epidemic Cholera
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Interstitial Lung Disease 2	Idiopathic Pulmonary Fibrosis Ipf Fibrocystic Pulmonary Dysplasia Pulmonary Fibrosis, Idiopathic Pulmonary Fibrosis, Idiopathic, Susceptibility To ILD2 Idiopathic Pulmonary Fibrosis, Familial Fibrosing Alveolitis, Cryptogenic Uip Cryptogenic Fibrosing Alveolitis Fibrosing Alveolitis Interstitial Pneumonitis, Usual Familial Idiopathic Pulmonary Fibrosis Idiopathic Fibrosing Alveolitis, Chronic Form Usual Interstitial Pneumonia Fibrosing Alveolitis Cryptogenic Hamman-Rich Disease Idiopathic Pulmonary Fibrosis Familial Interstitial Pneumonitis Usual Fibrosis Idiopathic Pulmonary Fibrosis, Pulmonary, Idiopathic Hamman-Rich Syndrome Chronic Idiopathic Pulmonary Fibrosis Acute Interstitial Pneumonia Interstitial Pulmonary Fibrosis Ipf - [Idiopathic Pulmonary Fibrosis] Idiopathic Lung Fibrosis Fibrosing Lung Disease Pulmonary Fibrosis Nos Fibrosing Pneumonitis
Intestinal Obstruction	Inspissated Milk Syndrome Milk Curd Syndrome
Prss1-Related Hereditary Pancreatitis
Diabetes Mellitus	Diabetes
Pulmonary Edema
Diarrhea	Diarrhoea Diarrhea Of Presumed Infectious Origin
Respiratory Failure	Acute Respiratory Failure Chronic Respiratory Failure Respiratory Insufficiency Acute-On-Chronic Respiratory Failure Acute And Chronic Respiratory Failure Respiratory Insufficiency/Failure Chronic Respiratory Disease Respiratory Disease Pulmonary Valve Insufficiency Chronic Disease Of Respiratory System Respiration Disorders Respiratory Tract Diseases Lung Failure Nos Pulmonary Failure Arf - [Acute Respiratory Failure] Acute Respiratory Insufficiency Acute Pulmonary Insufficiency Acute Respiration Failure Chronic Respiration Failure
Infertility
Fundus Dystrophy	Retinal Dystrophy Retinal Dystrophies Dystrophy, Retinal
Vas Deferens, Congenital Bilateral Aplasia Of, X-Linked	CBAVDX Congenital Bilateral Absence Of Vas Deferens, X-Linked X-Linked Congenital Bilateral Absence Of Vas Deferens Congenital Bilateral Aplasia Of The Vas Deferens, X-Linked Male Urogenital Diseases
Liddle Syndrome 1	Liddle Syndrome Pseudoaldosteronism LIDLS1 Lidls Pseudohyperaldosteronism Liddle'S Syndrome Pseudoprimary Hyperaldosteronism Pseudohyperaldosteronism Type 1 Liddles Syndrome
Pneumonia	Acute Pneumonia Pneumonias Infectious Pneumonia Pn - [Pneumonia] Lobar Pneumonia Nos Multifocal Pneumonia Orthostatic Pneumonia Pneumonia Nos Chronic Pneumonia Nos Atypical Pneumonia Passive Pneumonia Purulent Pneumonia Interstitial Lobar Pneumonia Pneumonia, Unspecified Pneumonia Due To Chlamydia Pneumonia Due To Chlamydia Pneumoniae Pneumonia Due To E. Coli Escherichia Coli Lobar Pneumonia Pneumonia Due To H. Influenzae Pneumonia Due To Hemophilus Influenzae Bronchopneumonia Due To H. Influenzae Haemophilus Influenzae Lobar Pneumonia Bronchopneumonia Due To Hemophilus Influenzae Pseudomonal Pneumonia Pseudomonas Pneumonia Pseudomonas Lobar Pneumonia Staphylococcal Pneumonia Staphylococcus Pneumonia Acute Staphylococcal Pneumonia Staphylococcal Double Pneumonia Staphylococcal Lobar Pneumonia Staphylococcal Purulent Pneumonia Staphylococcal Bronchopneumonia Pneumococcal Pneumonia Pneumococcus Pneumonia Bronchopneumonia Due To S. Pneumoniae Pneumococcal Lobar Pneumonia Streptococcal Pneumoniae Pneumonia Streptococcus Pneumoniae Lobar Pneumonia Pyemic Pneumococcal Embolism With Pneumonia Bronchopneumonia Due To Streptococcus Pneumoniae Pneumonia Due To Streptococcus, Group B Group B Streptococcal Pneumonia Adenovirus Pneumonia Adenoviral Pneumonia Adenovirus Viral Pneumonia Pneumonia Respiratory Syncytial Viral Parainfluenza Viral Pneumonia Parainfluenzal Pneumonia Parainfluenza Virus Pneumonia Human Metapneumovirus Pneumonia Human Metapneumovirus Infection Resulting In Pneumonia Pneumocystis Pneumonia Plasma Cells Pneumonia
Cholestasis, Intrahepatic, Of Pregnancy 3	ICP3 Cholestasis, Intrahepatic, Of Pregnancy, 3 Intrahepatic Cholestasis Of Pregnancy 3 Pregnancy Related Cholestasis 3 Cholestasis Of Pregnancy, Intrahepatic 3 Cholestasis, Intrahepatic, Of Pregnancy, Type 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (17)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15206	Glibenclamide	Inhibitor	99.83%	Yes
HY-13017	Ivacaftor	Agonist	99.97%	Yes
HY-B1125	Glucosamine		98.0%	Yes
HY-15448	Tezacaftor	Modulator	99.94%	Yes
HY-111772	Elexacaftor	Modulator	99.26%	Yes
HY-13262	Lumacaftor	Modulator	99.85%	Yes
HY-14832	Ataluren	Inhibitor	99.41%	Yes
HY-B0679	Lubiprostone	Activator	99.09%	Yes
HY-13017S	Ivacaftor-d9	Activator	99.79%	Unkown
HY-B1153	Glafenine	Activator	98.77%	Unkown
HY-106203	Crinecerfont	Antagonist	98.08%	Unkown
HY-B1153A	Glafenine hydrochloride	Activator	99.03%	Unkown
HY-B1153R	Glafenine (Standard)	Activator	98.59%	Unkown
HY-13017A	Ivacaftor benzenesulfonate	Agonist	/	Unkown
HY-13017B	Ivacaftor hydrate	Agonist	/	Unkown
HY-15206R	Glibenclamide (Standard)	Inhibitor	/	Unkown
HY-106203R	Crinecerfont (Standard)	Antagonist	/	Unkown

Clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15206A	Glibenclamide potassium	Inhibitor	/	Phase 4
HY-106203A	Crinecerfont hydrochloride	Antagonist	98.82%	Phase 3
HY-15448S	Tezacaftor-d4	Modulator	98.95%	Phase 3
HY-106203C	Crinecerfont tosylate	Antagonist	/	Phase 3
HY-145603	Vanzacaftor	Modulator	98.72%	Phase 2
HY-109177	Icenticaftor	Activator	99.66%	Phase 2
HY-18337	IOWH-032	Inhibitor	99.63%	Phase 2
HY-111680	Nesolicaftor	Modulator	99.37%	Phase 2
HY-109152	Navocaftor	Modulator	99.20%	Phase 2
HY-109187A	Posenacaftor sodium	Modulator	99.69%	Phase 2
HY-126394	Bamocaftor	Modulator	99.09%	Phase 2
HY-109027	Cavosonstat	Modulator	99.36%	Phase 2
HY-125381	CFTR corrector 2	Modulator	98.92%	Phase 2
HY-109187	Posenacaftor	Modulator	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (83)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16671	CFTR(inh)-172	Inhibitor	99.80%	Unkown
HY-150090	SRI-41315	Activator	99.68%	Unkown
HY-108575	Chromanol 293B	Inhibitor	99.2%	Unkown
HY-19778	(R)-BPO-27	Inhibitor	99.94%	Unkown
HY-18336	GlyH-101	Inhibitor	99.68%	Unkown
HY-N6818	5,7,4'-Trimethoxyflavone	Activator	99.65%	Unkown
HY-N2057	Steviol	Inhibitor	99.85%	Unkown
HY-12129	CP 154526 hydrochloride	Antagonist	99.76%	Unkown
HY-145603A	(R)-Vanzacaftor	Modulator	98.02%	Unkown
HY-111099	GLPG1837	Agonist	99.87%	Unkown
HY-115878	NJH-2-057	Modulator	98.84%	Unkown
HY-14179	PPQ-102	Inhibitor	99.73%	Unkown
HY-15206S1	Glyburide-d3	Inhibitor	99.64%	Unkown
HY-158002	IDOR-4	Modulator	96.98%	Unkown
HY-P1106A	K41498 TFA	Antagonist	98.71%	Unkown
HY-111111	Galicaftor	Modulator	98.56%	Yes
HY-150089	SRI-37240	Modulator	98.29%	Unkown
HY-152264	CFTR activator 1	Activator	99.94%	Unkown
HY-158991	I1421	Agonist	99.15%	Unkown
HY-119229	VRT-325	Modulator	99.15%	Unkown
HY-111772A	(R)-Elexacaftor	Modulator	99.44%	Unkown
HY-13017S3	Ivacaftor-d4	Agonist	97.32%	Unkown
HY-19778A	BPO-27 racemate	Inhibitor	98.50%	Unkown
HY-112267	Olacaftor	Modulator	99.60%	Unkown
HY-143344	NJH-2-056	Modulator	98.31%	Unkown
HY-136939	CFTR corrector 6	Activator	98.15%	Unkown
HY-15206S	Glyburide-d11	Inhibitor	99.39%	Unkown
HY-13017S2	Ivacaftor-d18		92.92%	Unkown
HY-19970	KM11060	Activator	98.71%	Unkown
HY-119936	GLPG2451	Activator	99.68%	Unkown
HY-164000	CFTR corrector 15	Modulator	99.67%	Unkown
HY-13017S1	Ivacaftor-d19	Agonist	98.10%	Unkown
HY-155742	CFTR corrector 12	Modulator	99.85%	Unkown
HY-15448A	(Rac)-Tezacaftor	Modulator	96.30%	Unkown
HY-117187	Corr4A	Modulator	99.58%	Unkown
HY-145603S	Vanzacaftor-d4		/	Unkown
HY-135279	CFTR corrector 4	Modulator	99.72%	Unkown
HY-W984122	CFTR corrector 17	Modulator	98.05%	Unkown
HY-N5101	Kobusin	Activator	99.93%	Unkown
HY-109187B	(R)-Posenacaftor sodium	Inhibitor	98.96%	Unkown
HY-103369	PG01	Activator	98.04%	Unkown
HY-153911	H2-Gamendazole		98.20%	Unkown
HY-147249	CFTR corrector 8	Modulator	95.86%	Unkown
HY-119179	UCCF-853	Modulator	99.93%	Unkown
HY-133013	GLPG-3221		/	Unkown
HY-N6818R	5,7,4'-Trimethoxyflavone (Standard)	Activator	/	Unkown
HY-P10806	kCAL01	Inhibitor	/	Unkown
HY-P3597	Urocortin III (mouse) free acid	Agonist	/	Unkown
HY-177313	AAG561	Antagonist	/	Unkown
HY-112267A	(R)-Olacaftor	Modulator	98.07%	Unkown
HY-158144	GLPG2737	Modulator	/	Unkown
HY-161753	CFTR potentiator 1	Activator	/	Unkown
HY-114725	VRT-532	Modulator	98.98%	Unkown
HY-164037	Riselcaftor	Modulator	/	Unkown
HY-14832S	Ataluren-d4	Inhibitor	/	Unkown
HY-174821	VU439	Modulator	/	Unkown
HY-116806	AF-2785	Inhibitor	/	Unkown
HY-145126	CP-628006	Activator	/	Unkown
HY-161895	CFTR corrector 14	Modulator	/	Unkown
HY-156522	CRF1 receptor antagonist-1	Antagonist	/	Unkown
HY-169000	CFTR corrector 16	Modulator	/	Unkown
HY-112363	Aloisine A	Activator	/	Unkown
HY-161894	CFTR corrector 13	Modulator	/	Unkown
HY-148806	Zatonacaftor	Modulator	/	Unkown
HY-165407	Neltenexine		/	Unkown
HY-185122	MS6178	Activator	/	Unkown
HY-133569	ARN23765	Modulator	/	Unkown
HY-183725	MS5128	Modulator	/	Unkown
HY-106203B	(R)-Crinecerfont	Antagonist	/	Unkown
HY-172555	CFTR corrector 18	Modulator	/	Unkown
HY-126394B	Bamocaftor potassium	Modulator	/	Unkown
HY-147315	CFTR corrector 9	Modulator	98.84%	Unkown
HY-P10226	PGD97	Activator	/	Unkown
HY-B0679S	Lubiprostone-d7	Activator	/	Unkown
HY-15448S1	Tezacaftor-d6	Modulator	/	Unkown
HY-153133	CFTR corrector 11	Modulator	99.80%	Unkown
HY-169536	CFTR activator 2	Activator	99.54%	Unkown
HY-134385	6-PhEt-dATP		/	Unkown
HY-14832S1	Ataluren-13C6	Inhibitor	/	Unkown
HY-15206S2	Glibenclamide-13C6	Inhibitor	/	Unkown
HY-B1125S	Glucosamine-13C6		/	Unkown
HY-183001	ATX-012		/	Unkown
HY-13017S4	Ivacaftor-13C6	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CFTR	VGNC	VGNC:71020
Felis catus	CFTR	VGNC	VGNC:60829
Mus musculus	CFTR	MGD	MGI:88388
Bos taurus	CFTR	VGNC	VGNC:50053
Canis familiaris	CFTR	VGNC	VGNC:39180
Rattus norvegicus	CFTR	RGD	RGD:2332
Others	CFTR	NCBI