2. Membrane Transporter/Ion Channel
  3. Potassium Channel CFTR
  4. Chromanol 293B

Chromanol 293B is a selective blocker of the slow delayed rectifier K+ current (IKs) with IC50 of 1-10 μM and a weak inhibitor of KATP channel. Chromanol 293B also blocks the CFTR chloride current with an IC50 of 19 μM.

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Chromanol 293B Chemical Structure

Chromanol 293B Chemical Structure

CAS No. : 163163-23-3

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5 mg USD 270 In-stock
10 mg USD 430 In-stock
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Based on 1 publication(s) in Google Scholar

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Chromanol 293B Related Antibodies

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Description

Chromanol 293B is a selective blocker of the slow delayed rectifier K+ current (IKs) with IC50 of 1-10 μM and a weak inhibitor of KATP channel. Chromanol 293B also blocks the CFTR chloride current with an IC50 of 19 μM[1].

Molecular Weight

324.40

Formula

C15H20N2O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCS(N([C@H]1C2=CC(C#N)=CC=C2OC(C)([C@@H]1O)C)C)(=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMF : ≥ 30 mg/mL (92.48 mM)

DMSO : ≥ 30 mg/mL (92.48 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : ≥ 2 mg/mL (6.17 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0826 mL 15.4131 mL 30.8261 mL
5 mM 0.6165 mL 3.0826 mL 6.1652 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol / DMF / DMSO 1 mM 3.0826 mL 15.4131 mL 30.8261 mL 77.0654 mL
5 mM 0.6165 mL 3.0826 mL 6.1652 mL 15.4131 mL
DMF / DMSO 10 mM 0.3083 mL 1.5413 mL 3.0826 mL 7.7065 mL
15 mM 0.2055 mL 1.0275 mL 2.0551 mL 5.1377 mL
20 mM 0.1541 mL 0.7707 mL 1.5413 mL 3.8533 mL
25 mM 0.1233 mL 0.6165 mL 1.2330 mL 3.0826 mL
30 mM 0.1028 mL 0.5138 mL 1.0275 mL 2.5688 mL
40 mM 0.0771 mL 0.3853 mL 0.7707 mL 1.9266 mL
50 mM 0.0617 mL 0.3083 mL 0.6165 mL 1.5413 mL
60 mM 0.0514 mL 0.2569 mL 0.5138 mL 1.2844 mL
80 mM 0.0385 mL 0.1927 mL 0.3853 mL 0.9633 mL
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Chromanol 293B Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chromanol 293B163163-23-3Potassium ChannelCFTRKcsACystic fibrosis transmembrane conductance regulatorInhibitorinhibitorinhibit

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