(-)-Chromanol 293B
Based on 1 Customer Validation
(-)-Chromanol 293B is a potent and selective inhibitor of the slow component of delayed rectifier K+ current (IKs). (-)-Chromanol 293B can be used for the research of antiarrhythmic.
For research use only. We do not sell to patients.
- Purity: 99.83%
- CAS No.: 163163-24-4
- Formula: C15H20N2O4S
- Molecular Weight:324.40
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
Biological Activity
IKs[1]
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Oocyte | IC50 |
5 μM
Compound: (3R,4S)-enantiomer of 21
|
Inhibition of guinea pig Iks potassium channel expressed in Xenopus oocytes
Inhibition of guinea pig Iks potassium channel expressed in Xenopus oocytes
|
[PMID: 14998318] |
| Oocyte | IC50 |
5 μM
Compound: 1a
|
Inhibition of human IKs-channel expressed in Xenopus oocytes,(Experiment 1)
Inhibition of human IKs-channel expressed in Xenopus oocytes,(Experiment 1)
|
[PMID: 11689069] |
(-)-Chromanol 293B selectively inhibits the KvLQT11+minK ion channel complex[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 163163-24-4
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Appearance Solid
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Molecular Weight 324.40
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Formula C15H20N2O4S
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Color White to off-white
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SMILES
CCS(=O)(N([C@@H]1[C@@H](O)C(C)(C)OC2=CC=C(C#N)C=C12)C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)