KLHL18 - kelch like family member 18 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23276

Summary

Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Involved in positive regulation of mitotic cell cycle phase transition and protein ubiquitination. Predicted to be part of Cul3-RING ubiquitin Ligase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Ubiquitous expression in bone marrow (RPKM 6.1), skin (RPKM 5.8) and 25 other tissues.

KLHL18 Products (1)

mRNA Protein Name
NM_025010.5 NP_079286.2 kelch-like protein 18

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23213400 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of mitotic cell cycle phase transition IMP
IMP: Inferred from mutant phenotype
23213400 GOA
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
23213400 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLHL18 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
KLHL18 O94889 PRKN Homo sapiens O60260-5
Y2H Pooling
32814053
Intra
KLHL18 O94889 PRKN Homo sapiens O60260-5
Validated Y2H
32814053
Intra
KLHL18 O94889 PRKN Homo sapiens O60260-5
Y2H Array
32814053
Intra
KLHL18 O94889 CFTR Homo sapiens P13569
Ub Reconstruction
35156780
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07354 KLHL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07355 KLHL11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07356 KLHL12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07357 KLHL13 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07358 KLHL14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07359 KLHL15 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07360 KLHL17 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-182927 KLHL12 ligand-1 / Unkown