GLPG-3221
GLPG-3221 is a potent, orally active corrector of CFTR (cystic fibrosis transmembrane conductance regulator), with an EC50 of 105 nM. GLPG-3221 can be uesd for the treatment of cystic fibrosis.
For research use only. We do not sell to patients.
- CAS No.: 2222264-64-2
- Formula: C30H37F3N2O6
- Molecular Weight:578.62
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
GLPG-3221 (1 mg/kg; p.o.)treatment shows the F% value is 53%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rat[1]
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Dosage:1 mg/kg
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Administration:i.v. administration (Pharmacokinetic Analysis)
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Result:The Cl and t1/2 were 0.13 L/h/kg and 3 hours, respectively.
Chemical Information
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CAS No. 2222264-64-2
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Molecular Weight 578.62
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Formula C30H37F3N2O6
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SMILES
O=C(O)[C@H]1N(C([C@@H]2CCCCO2)=O)[C@@H](C3=CC=CC=C3C)[C@@H](OCC4=CC(C(F)(F)F)=CN=C4OC)[C@@H]1C(C)(C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GLPG-3221 Related Classifications
HY-133013 Related Classifications
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