1. Membrane Transporter/Ion Channel
  2. CFTR
  3. GLPG-3221

GLPG-3221 

Cat. No.: HY-133013
Handling Instructions

GLPG-3221 is a potent, orally active corrector of CFTR (cystic fibrosis transmembrane conductance regulator), with an EC50 of 105 nM. GLPG-3221 can be uesd for the treatment of cystic fibrosis.

For research use only. We do not sell to patients.

GLPG-3221 Chemical Structure

GLPG-3221 Chemical Structure

CAS No. : 2222264-64-2

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Description

GLPG-3221 is a potent, orally active corrector of CFTR (cystic fibrosis transmembrane conductance regulator), with an EC50 of 105 nM. GLPG-3221 can be uesd for the treatment of cystic fibrosis[1].

In Vivo

GLPG-3221 (1 mg/kg; i.v.) treatment shows the Cl and t1/2 are 0.13 L/h/kg and 3 hours, respectively[1].
GLPG-3221 (1 mg/kg; p.o.)treatment shows the F% value is 53%[1].

Animal Model: Rat[1] 
Dosage: 1 mg/kg
Administration: i.v. administration (Pharmacokinetic Analysis)
Result: The Cl and t1/2 were 0.13 L/h/kg and 3 hours, respectively.
Molecular Weight

578.62

Formula

C₃₀H₃₇F₃N₂O₆

CAS No.

2222264-64-2

SMILES

O=C(O)[[email protected]]1N(C([[email protected]@H]2CCCCO2)=O)[[email protected]@H](C3=CC=CC=C3C)[[email protected]@H](OCC4=CC(C(F)(F)F)=CN=C4OC)[[email protected]@H]1C(C)(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

GLPG-3221GLPG3221GLPG 3221CFTRCystic fibrosis transmembrane conductance regulatororalcysticfibrosisCYP3A4Inhibitorinhibitorinhibit

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